2007
DOI: 10.1016/j.cca.2006.08.010
|View full text |Cite
|
Sign up to set email alerts
|

Concordance between the deduced acetylation status generated by high-speed Real-time PCR based NAT2 genotyping of seven single nucleotide polymorphisms and human NAT2 phenotypes determined by a caffeine assay

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

0
16
0
3

Year Published

2007
2007
2018
2018

Publication Types

Select...
8

Relationship

1
7

Authors

Journals

citations
Cited by 20 publications
(19 citation statements)
references
References 11 publications
0
16
0
3
Order By: Relevance
“…The inference of acetylation phenotype from NAT2 genotype is widely accepted, and the phenotype prediction accuracy can reach up to 100% [46]. However, lack of complete genotype-phenotype concordance is not uncommon [1319].…”
Section: Discussionmentioning
confidence: 99%
“…The inference of acetylation phenotype from NAT2 genotype is widely accepted, and the phenotype prediction accuracy can reach up to 100% [46]. However, lack of complete genotype-phenotype concordance is not uncommon [1319].…”
Section: Discussionmentioning
confidence: 99%
“…Even though most studies showed a high concordance between genotypes and phenotypes, none of them showed 100% concordance. NAT2*4, NAT2*12A and NAT2*13 are related to rapid acetylator phenotypes, whereas NAT2*5, NAT2*6 and NAT2*7 are related to slow acetylator phenotypes (Butcher et al 2002;Cascorbi et al 1995;Hickman and Sim 1991;Rihs et al 2007;Woolhouse et al 1997). The highest discordance (86%) between genotypes and phenotypes was reported in the Hmong population (Southeast Asian immigrants from Laos since 1975) in Minnesota (Straka et al 2006).…”
Section: Introductionmentioning
confidence: 99%
“…8,11 Additionally, the phenotype analysis, usually accommodated only bimodal distribution (slow and rapid group) 12,13 and does not differentiate between the intermediate group from the rapid group. Therefore, in the present study we conducted a study to define the rapid and intermediate NAT2 phenotype based on both genotyping and urinary assay and determine the concordance rate between both methods.…”
Section: 10mentioning
confidence: 99%