Concordance for gender in sib pairs affected with schizophrenia and related disorders

Maier, Wolfgang; Lichtermann, Dirk; Minges, Jürgen; Franke, Petra; Heun, Reinhard; Hallmayer, J.

doi:10.1016/0920-9964(93)90012-8

Cited by 10 publications

(8 citation statements)

References 13 publications

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“…Not showing evidence of deviations of gender-ratios from expectations, our study included 29 (Table 1) or 20 (Table 3) affected sibships and 51 affected sibling pairs (Tables 1 and 2). The numbers are in-between those of the study by Maier et al (1993), but in contrast we did not find even a tendency towards unusual gender-concordance rates.…”

Section: Discussioncontrasting

confidence: 68%

“…The pseudo-autosomal hypothesis predicts that when fathers transmit the disorder, schizophrenia-concordant sibling pairs are more likely to be concordant by gender than when mothers transmit the illness. Some studies have observed this pattern (Crow et al 1989;, whereas others have not (Asherson et al 1992;Maier et al 1993;Wang et al 1993). When molecular- (Asherson et al 1992;Wang et al 1993), but some have supported it (Collinge et al 1991;d'Amato et al 1992).…”

Section: Introductionmentioning

confidence: 85%

“…Sampling systematically, Maier et al (1993) applied statistical techniques to allow for the differing effects of age on each gender, parental origins and unaffected siblings. They tested three different schizophrenia disease models.…”

Section: Discussionmentioning

confidence: 99%

“…For decades there have been reports about a higher prevalence of same-gender sibling pairs than mixed-gender sibling pairs suffering from schizophrenia and related disorders (Mott 1910;Myerson 1925;Schulz 1932;yon Zehnder 1941;Penrose 1942;Rosenthal 1962;Tsuang 1967;Crow et al 1989;Crow 1991;Shimizu et al 1991;Asherson et al 1992;Gorwood et al 1992;Maier et al 1993;Wang et al 1993). Sturt and Shur (1985) and Curtis and Gurling (1990) argued that diagnostic heterogeneity, methodological errors in statistical analysis and incomplete biased sampling Harald N. Aschauer (5:~) 9 Kurt Meszaros 9 Ulrike Willinger Gabriele Fischer 9 Rainer Strobl 1 -Henriette Beran Elisabeth Lenzinger 9 Eleonore Reiter.…”

Section: Introductionmentioning

confidence: 98%

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Non-concordance by gender for schizophrenia and related disorders in sibships

Aschauer

Meszaros

Willinger

et al. 1994

Eur Arch Psychiatry Clin Nuerosci

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We analysed gender-concordance rates among 29 prospectively sampled schizophrenic probands and their 39 affected and 71 unaffected siblings. We did not find any unusual concordance rates. We found no same-gender concordance particularly in siblings affected by schizophrenia and related disorders. We considered unaffected siblings in an additional attempt to make valid and unbiased comparisons between genders, but this reduced the number of informative sibships to 20. We stratified the siblings of probands by sibship and by the proband's gender in order to check gender distribution within families. The data do not support hypotheses that schizophrenia is pseudo-autosomal or male-female chromosomally transmitted.

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Section: Discussioncontrasting

confidence: 68%

Section: Introductionmentioning

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

See 2 more Smart Citations

Non-concordance by gender for schizophrenia and related disorders in sibships

Aschauer

Meszaros

Willinger

et al. 1994

Eur Arch Psychiatry Clin Nuerosci

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“…Although long a subject of interest (59,60), relatively recent attention has focused on gender similarity in pairs of schizophrenic relatives as a way of evaluating hypotheses of X-linkage (61)(62)(63)(64). This hypothesis predicts an excess of same-sex affected sibling pairs.…”

Section: Resemblance For Gender and Age At Onsetmentioning

confidence: 99%

Resemblance of psychotic symptoms and syndromes in affected sibling pairs from the Irish Study of High-Density Schizophrenia Families: evidence for possible etiologic heterogeneity

1997

AJP

112

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Schizophrenia and the androgen receptor gene: Report of a sibship showing co‐segregation with reifenstein syndrome but no evidence for linkage in 23 multiply affected families

et al. 1995

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Crow et al. [1993: Am J Med Genet (Neuropsychiatr Genet) 48:159-160] have reported excess sharing of alleles by male sibling pairs with schizophrenia, at a triplet repeat marker within the androgen receptor gene, indicating that mutations at or near this gene may be a risk factor for males. In this report, we describe a pair of male siblings concordant for both schizophrenia and Reifenstein syndrome, which is caused by a mutation in this gene. This provides support for the hypothesis that the androgen receptor may contribute to liability to develop schizophrenia. Because of this, we have examined a collection of 23 pedigrees multiply affected by schizophrenia for linkage to the androgen receptor. We have found no evidence for linkage by both the LOD score and affected sibling-pair methods, under a range of genetic models with a broad and narrow definition of phenotype, and when families with male-to-male transmission are excluded. However, because of the small number of informative male-male pairs in our sample, we cannot confirm or refute the excess allele sharing for males reported by Crow.

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Concordance for gender in sib pairs affected with schizophrenia and related disorders

Cited by 10 publications

References 13 publications

Non-concordance by gender for schizophrenia and related disorders in sibships

Non-concordance by gender for schizophrenia and related disorders in sibships

Resemblance of psychotic symptoms and syndromes in affected sibling pairs from the Irish Study of High-Density Schizophrenia Families: evidence for possible etiologic heterogeneity

Schizophrenia and the androgen receptor gene: Report of a sibship showing co‐segregation with reifenstein syndrome but no evidence for linkage in 23 multiply affected families

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