Concordance of 24‑h intraocular pressure curve in patients with untreated unilateral primary open‑angle glaucoma

Abstract

The present study aimed to assess the concordance of 24-h intraocular pressure (IOP) curves between glaucomatous and contralateral eyes for patients with untreated unilateral primary open-angle glaucoma (POAG). A total of 32 patients with unilateral POAG and 32 age-matched normal subjects were enrolled. The IOP measurements were performed every 2 h over a 24-h period. The concordance of the 24-h IOP curves was assessed via the correlation coefficient (r), intraclass correlation coefficient (ICC) and repeated-measures analysis of variance (ANOVA). No significant difference was identified between all IOPs, as well as the mean, peak and trough IOP or IOP fluctuations of the paired eyes in the two groups. The strength of association of all IOPs was moderate in the glaucoma group (r, 0.752-0.867) and the normal controls (r, 0.625-0.873). IOP readings at each time-point indicated a high agreement in the glaucoma group (ICC, 0.857-0.929) and the normal controls (ICC, 0.768-0.932). Repeated-measures ANOVA indicated that the 24-h IOP curves of the paired eyes had parallel profiles in the two study groups (P=0.837 and P=0.897, respectively). The glaucoma patients had significantly higher proportions of all IOPs displaying absolute differences of ≥2 and ≥3 mmHg (46.09 vs. 35.68%, P<0.001; 29.69 vs. 12.50%, P<0.001, respectively). In conclusion, the 24-h IOP curves of the paired eyes had parallel profiles in unilateral glaucoma patients and normal subjects. However, unilateral glaucoma patients had a significantly larger proportion of IOP differences of ≥2 and ≥3 mmHg.

<p>Evaluation of Routine Health Examination for Screening Primary Open Angle Glaucoma in Eastern China: A Hospital-Based Cross-Sectional Study</p>

“…The initial IOPs and the mean IOPs at 24 hours in the RHE and non-RHE groups were similar and consistent with the findings from previous studies. 12,13,[25][26][27] These findings suggested that the average IOP in the untreated POAG population did not significantly change as the disease progressed during the middle stage of glaucoma. However, the IOP at 10:00 PM and 2:00 AM in the non-RHE group was higher than that in the RHE group.…”

“…In previous studies, there were no significant differences in the 24-hour IOP monitoring parameters including the mean IOP, peak IOP, trough IOP, and the fluctuation in IOP (peak IOP-trough IOP) between the glaucomatous and non-glaucomatous eyes of unilateral POAG patients. 25,26 Meanwhile, the vertical cup/disc ratios and the MD in glaucomatous and non-glaucomatous eye were 0.6±0.2 versus 0.5 ±0.1, and 5.41±4.67 dB versus 1.05±1.11 dB, respectively. 25,26 These studies suggested that there was no obvious change in the 24-hour IOP curve during the early stage of glaucoma.…”

“…25,26 Meanwhile, the vertical cup/disc ratios and the MD in glaucomatous and non-glaucomatous eye were 0.6±0.2 versus 0.5 ±0.1, and 5.41±4.67 dB versus 1.05±1.11 dB, respectively. 25,26 These studies suggested that there was no obvious change in the 24-hour IOP curve during the early stage of glaucoma. However, the 24-IOP trend during the middle stage of glaucoma remains unknown.…”

Efficacy of Nimodipine Combined with Latanoprost in Treating Open-Angle Glaucoma and Its Influence on Ocular Hemodynamics and Visual Field Defects

“…In addition, the 24-hour peak intraocular pressure is an important basis for the diagnosis of glaucoma. 19 NEI VFQ-25, with favorable validity and reliability, can comprehensively assess vision-related quality of life of patients with eye diseases, which is suitable for the diagnosis of common clinical eye diseases. 20 Optic disc damage and visual field defects are the main pathological changes of open-angle glaucoma.…”

Downregulation of lncRNA MIR17HG reduced tumorigenicity and Treg‐mediated immune escape of non‐small‐cell lung cancer cells through targeting the miR‐17‐5p/RUNX3 axis

“…[ 18 ] For instance, miR‐17‐5p was significantly downregulated in NSCLC, and miR‐17‐5p suppressed cell proliferation and triggered cell apoptosis through regulating TGFβR2. [ 19 ] In addition, lncRNA PART1 enhanced proliferation and progression of NSCLC cells by sponging miR‐17‐5p. [ 20 ] These suggested that miR‐17‐5p might be involved in the regulation of lncRNAs in NSCLC development.…”