Concordance of Diurnal Intraocular Pressure between Fellow Eyes in Primary Open-Angle Glaucoma

Dinn, R.; Zimmerman, M. Bridget; Shuba, Lesya M.; Doan, Andrew; Maley, Michael K.; Greenlee, Emily C.; Alward, Wallace L.M.; Kwon, Young H.

doi:10.1016/j.ophtha.2007.01.018

Cited by 38 publications

(30 citation statements)

References 18 publications

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“…This is similar to that found in earlier studies. [192021] This pattern was less obvious in eyes on treatment with PGA similar to that reported previously. [1920]…”

Section: Discussionsupporting

confidence: 87%

Contralateral intraocular pressure lowering effect of prostaglandin analogues

Rao

Senthil

Garudadri

2014

Indian J Ophthalmol

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Background:Though the use of prostaglandin analogues (PGA) for reduction of intraocular pressure (IOP) has shown a marked increase, studies evaluating the contralateral effects of PGA are limited.Aims:To evaluate if PGA treatment in one eye has an effect on the IOP of the untreated fellow eye.Design:Retrospective study.Materials and Methods:Thirty patients of open-angle glaucoma with no previous antiglaucoma treatment underwent 24-hour diurnal IOP phasing. They subsequently were started on a uniocular trial with PGA, and had office diurnal IOP measurements 6 weeks later. Twenty-four hour diurnal consisted of 8 IOP readings over 24 hours and office diurnal consisted of 4 IOP readings between 8 AM and 6 PM at 3 hourly intervals.Statistical Analysis:IOPs of the fellow eye during the office diurnal were compared with IOPs at similar time points during the 24-hour diurnal using paired t-tests.Results:Mean (± standard deviation) IOP in the treated eye reduced (P < 0.001) from 17.17 ± 3.2 mm Hg at baseline to 13.7 ± 2.4 mm Hg at 6 weeks, while that in the untreated eye reduced from 16.4 ± 3.1 mm Hg to 14.8 ± 2.7 mm Hg (P = 0.01). The decrease in IOP in the untreated fellow eye was statistically significant at 8 AM (2.7 mm Hg, P = 0.003) and 11 AM (2.3 mm Hg, P = 0.01) but not so at 2 PM (1.2 mm Hg, P = 0.10) and 5 PM (0.9 mm Hg, P = 0.19). The amount of IOP reduction in the untreated eye was significantly associated with the magnitude of IOP reduction in the treated eye (β = 0.69, P = 0.008).Conclusion:Uniocular PGA treatment tends to reduce the IOP of the untreated fellow eye.

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“…This is similar to that found in earlier studies. [192021] This pattern was less obvious in eyes on treatment with PGA similar to that reported previously. [1920]…”

Section: Discussionsupporting

confidence: 87%

Contralateral intraocular pressure lowering effect of prostaglandin analogues

Rao

Senthil

Garudadri

2014

Indian J Ophthalmol

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“…Reports on the symmetry of diurnal curves between the right and left eyes have been conflicting, but the most recent studies have found strong correlations of IOP fluctuations between the fellow eyes in patients with untreated glaucoma (r = 0.84) and ocular hypertensive patients (r = 0.72) using Goldmann applanation tonometry. 21,22 Nevertheless, asymmetric fluctuations between the right and left eyes do occur in both untreated glaucoma patients and older healthy individuals, with estimates of the prevalence of this phenomenon varying widely. [21][22][23][24] These variations may account for the fact that several controls in our study had asymmetric IOP, whereas many glaucoma patients were observed to have symmetrical IOP with only 1 measurement.…”

Section: Discussionmentioning

confidence: 99%

“…21,22 Nevertheless, asymmetric fluctuations between the right and left eyes do occur in both untreated glaucoma patients and older healthy individuals, with estimates of the prevalence of this phenomenon varying widely. [21][22][23][24] These variations may account for the fact that several controls in our study had asymmetric IOP, whereas many glaucoma patients were observed to have symmetrical IOP with only 1 measurement. The value of IOP asymmetry as a diagnostic consideration should be weighted heavily in patients who show consistent IOP asymmetry on repeat clinic visits, and especially if those measurements are recorded within 2 hours of the same time of the day as the baseline IOP.…”

Section: Discussionmentioning

confidence: 99%

The Value of Intraocular Pressure Asymmetry in Diagnosing Glaucoma

Williams

Gatla

Leiby

et al. 2013

Journal of Glaucoma

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“…[28][29][30][31] Note, however, that 24-h IOP in HTG eyes showed striking concordance of IOP variation between fellow eyes of 1.6-2.0 mmHg, and the estimated probability of a 2 mmHg difference was 68-90% and a 3 mmHg difference was 78-95% for all time intervals studied. 32 More recently, these same researchers looked at the diurnal IOP fluctuation in untreated glaucoma suspect (GS) and NTG eyes. 33 They took six IOP measurements from 7 AM to 10 PM to evaluate the concordance of IOP between fellow eyes.…”

Section: Asymmetry Of Disease and Iopmentioning

confidence: 99%

Normal Pressure Glaucoma

Prum

2010

The Glaucoma Book

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Concordance of Diurnal Intraocular Pressure between Fellow Eyes in Primary Open-Angle Glaucoma

Cited by 38 publications

References 18 publications

Contralateral intraocular pressure lowering effect of prostaglandin analogues

Contralateral intraocular pressure lowering effect of prostaglandin analogues

The Value of Intraocular Pressure Asymmetry in Diagnosing Glaucoma

Normal Pressure Glaucoma

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