Concordance of regional hypoperfusion by pCASL MRI and 15O-water PET in frontotemporal dementia: Is pCASL an efficacious alternative?

Ssali, Tracy; Narciso, Lucas; Hicks, Justin; Liu, Linshan; Jesso, Sarah; Richardson, L. A.; Günther, Matthias; Konstandin, Simon; Eickel, Klaus; Prato, Frank S.; Anazodo, Udunna; Finger, Elizabeth; Lawrence, Keith St.

doi:10.1016/j.nicl.2022.102950

Cited by 9 publications

(9 citation statements)

References 62 publications

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“…According to the aforementioned quality assessment tool [ 19 ], all included studies were rated fair to good. Nineteen (58%) comprised samples of subjects with SCD plus and patients with NCD [ 21 – 24 , 26 , 30 – 32 , 34 , 35 , 37 , 38 , 43 , 46 – 52 ], including mild cognitive impairment (MCI), AD, frontotemporal lobar degeneration (FTLD), DLB and vascular cognitive impairment (VCI), according to the corresponding diagnostic criteria [ 17 , 53 – 63 ]. Given that subjects with SCD plus have “features that increase the likelihood of preclinical AD” [ 17 ], we report them as a distinct subgroup belonging to the spectrum of cognitive decline.…”

Section: Resultsmentioning

confidence: 99%

Arterial spin labelling magnetic resonance imaging and perfusion patterns in neurocognitive and other mental disorders: a systematic review

Ferreira,

Bastos-Leite

2024

Neuroradiology

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We reviewed 33 original research studies assessing brain perfusion, using consensus guidelines from a “white paper” issued by the International Society for Magnetic Resonance in Medicine Perfusion Study Group and the European Cooperation in Science and Technology Action BM1103 (“Arterial Spin Labelling Initiative in Dementia”; https://www.cost.eu/actions/BM1103/). The studies were published between 2011 and 2023 and included participants with subjective cognitive decline plus; neurocognitive disorders, including mild cognitive impairment (MCI), Alzheimer’s disease (AD), frontotemporal lobar degeneration (FTLD), dementia with Lewy bodies (DLB) and vascular cognitive impairment (VCI); as well as schizophrenia spectrum disorders, bipolar and major depressive disorders, autism spectrum disorder, attention-deficit/hyperactivity disorder, panic disorder and alcohol use disorder. Hypoperfusion associated with cognitive impairment was the major finding across the spectrum of cognitive decline. Regional hyperperfusion also was reported in MCI, AD, frontotemporal dementia phenocopy syndrome and VCI. Hypoperfused structures found to aid in diagnosing AD included the precunei and adjacent posterior cingulate cortices. Hypoperfused structures found to better diagnose patients with FTLD were the anterior cingulate cortices and frontal regions. Hypoperfusion in patients with DLB was found to relatively spare the temporal lobes, even after correction for partial volume effects. Hyperperfusion in the temporal cortices and hypoperfusion in the prefrontal and anterior cingulate cortices were found in patients with schizophrenia, most of whom were on medication and at the chronic stage of illness. Infratentorial structures were found to be abnormally perfused in patients with bipolar or major depressive disorders. Brain perfusion abnormalities were helpful in diagnosing most neurocognitive disorders. Abnormalities reported in VCI and the remaining mental disorders were heterogeneous and not generalisable.

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Section: Resultsmentioning

confidence: 99%

Arterial spin labelling magnetic resonance imaging and perfusion patterns in neurocognitive and other mental disorders: a systematic review

Ferreira,

Bastos-Leite

2024

Neuroradiology

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“…Finally, the reliability of VSASL to detect between-region CBF variations could be facilitated with a direct comparison with 15 O-water PET as a gold standard modality for CBF mapping ( Fan et al, 2016 ). Hybrid PET/MRI would be ideally employed to validate CBF quantification by VSASL with simultaneous measurement by 15 O-water PET to ensure capturing the same physiologic state ( T. Ssali et al, 2022b ; Zhang et al, 2014 ).…”

Section: Discussionmentioning

confidence: 99%

Test-retest reliability of 3D velocity-selective arterial spin labeling for detecting normal variations of cerebral blood flow

Liu

Zhu

et al. 2023

NeuroImage

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“…Neurologically healthy participants were recruited through advertisements or the volunteer pool. PET and MRI data were collected at the Lawson Health Research Institute as part of a clinical study involving patients with frontotemporal dementia 27,28 . Complete data sets were acquired from 13 individuals (64 ± 10 years, 80 ± 20 kg, 8M/5F; average injected activity, 730 ± 60 MBq [range 620–790 MBq]; average injected activity per body weight, 9.4 ± 2.4 MBq/kg [range 5.6–14.1 MBq/kg]).…”

Section: Methodsmentioning

confidence: 99%

Noninvasive Quantification of Cerebral Blood Flow Using Hybrid PET/MR Imaging to Extract the [¹⁵O]H₂O Image‐Derived Input Function Free of Partial Volume Errors

Narciso

Ssali

Liu

et al. 2022

Magnetic Resonance Imaging

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Background Quantification of cerebral blood flow (CBF) with [15O]H2O‐positron emission tomography (PET) requires arterial sampling to measure the input function. This invasive procedure can be avoided by extracting an image‐derived input function (IDIF); however, IDIFs are sensitive to partial volume errors due to the limited spatial resolution of PET. Purpose To present an alternative hybrid PET/MR imaging of CBF (PMRFlowIDIF) that uses phase‐contrast (PC) MRI measurements of whole‐brain (WB) CBF to calibrate an IDIF extracted from a WB [15O]H2O time‐activity curve. Study Type Technical development and validation. Animal Model Twelve juvenile Duroc pigs (83% female). Population Thirteen healthy individuals (38% female). Field Strength/Sequences 3 T; gradient‐echo PC‐MRI. Assessment PMRFlowIDIF was validated against PET‐only in a porcine model that included arterial sampling. CBF maps were generated by applying PMRFlowIDIF and two previous PMRFlow methods (PC‐PET and double integration method [DIM]) to [15O]H2O‐PET data acquired from healthy individuals. Statistical Tests PMRFlow and PET CBF measurements were compared with regression and correlation analyses. Paired t‐tests were performed to evaluate differences. Potential biases were assessed using one‐sample t‐tests. Reliability was assessed by intraclass correlation coefficients. Statistical significance: α = 0.05. Results In the animal study, strong agreement was observed between PMRFlowIDIF (average voxel‐wise CBF, 58.0 ± 16.9 mL/100 g/min) and PET (63.0 ± 18.9 mL/100 g/min). In the human study, PMRFlowDIM (y = 1.11x − 5.16, R2 = 0.99 ± 0.01) and PMRFlowPC−PET (y = 0.87x + 3.82, R2 = 0.97 ± 0.02) performed similarly to PMRFlowIDIF, and CBF was within the expected range (eg, 49.7 ± 7.2 mL/100 g/min for gray matter). Data Conclusion Accuracy of PMRFlowIDIF was confirmed in the animal study with the primary source of error attributed to differences in WB CBF measured by PC MRI and PET. In the human study, differences in CBF from PMRFlowIDIF, PMRFlowDIM, and PMRFlowPC−PET were due to the latter two not accounting for blood‐borne activity. Level of Evidence 2 Technical Efficacy Stage 1

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Concordance of regional hypoperfusion by pCASL MRI and 15O-water PET in frontotemporal dementia: Is pCASL an efficacious alternative?

Cited by 9 publications

References 62 publications

Arterial spin labelling magnetic resonance imaging and perfusion patterns in neurocognitive and other mental disorders: a systematic review

Arterial spin labelling magnetic resonance imaging and perfusion patterns in neurocognitive and other mental disorders: a systematic review

Test-retest reliability of 3D velocity-selective arterial spin labeling for detecting normal variations of cerebral blood flow

Noninvasive Quantification of Cerebral Blood Flow Using Hybrid PET/MR Imaging to Extract the [¹⁵O]H₂O Image‐Derived Input Function Free of Partial Volume Errors

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Concordance of regional hypoperfusion by pCASL MRI and 15O-water PET in frontotemporal dementia: Is pCASL an efficacious alternative?

Cited by 9 publications

References 62 publications

Arterial spin labelling magnetic resonance imaging and perfusion patterns in neurocognitive and other mental disorders: a systematic review

Arterial spin labelling magnetic resonance imaging and perfusion patterns in neurocognitive and other mental disorders: a systematic review

Test-retest reliability of 3D velocity-selective arterial spin labeling for detecting normal variations of cerebral blood flow

Noninvasive Quantification of Cerebral Blood Flow Using Hybrid PET/MR Imaging to Extract the [15O]H2O Image‐Derived Input Function Free of Partial Volume Errors

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Product

Resources

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Noninvasive Quantification of Cerebral Blood Flow Using Hybrid PET/MR Imaging to Extract the [¹⁵O]H₂O Image‐Derived Input Function Free of Partial Volume Errors