Concordancia entre cinco definiciones de síndrome metabólico. Cartagena, Colombia

García, Gustavo Mora; Madrid, Germán Salguedo; Diaz, María Ruíz; Clason, Enrique Ramos; Bello, Ariel; Fortich, Álvaro; Mazenett, Enrique; Camargo, Doris Gómez; Gómez-Alegría, Claudio

doi:10.1590/s1135-57272012000300009

Cited by 16 publications

(15 citation statements)

References 29 publications

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“…Sample size and study power were calculated using the browser program Genetic Power Calculator ( ). 34 , 35 As parameters, an outcome (metabolic syndrome) prevalence at 33%, 36 25% minor allele frequency (MAF), complete linkage disequilibrium (D′ = 1), and a 5% alpha coefficient were assumed. Thus, a total sample of 605 subjects was set as the minimum size necessary to achieve 80% power to discriminate genetic associations with a 1.35/1.6 (heterozygote/homozygote) odds ratio (OR).…”

Section: Methodsmentioning

confidence: 99%

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A Common Variation in the Caveolin 1 Gene Is Associated with High Serum Triglycerides and Metabolic Syndrome in an Admixed Latin American Population

Mora-García

Gómez‐Camargo

Alario

et al. 2018

Metabolic Syndrome and Related Disorders

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Background: The caveolin 1 (CAV1) gene has been associated with metabolic traits in animal models and human cohorts. Recently, a prevalent variant in CAV1 has been found to be related to metabolic syndrome in Hispanics living in North America. Since Hispanics represent an admixed population at high risk for cardiovascular diseases, in this study a Latin American population with a similar genetic background was assessed.Objective: To analyze a genetic association between CAV1 and metabolic traits in an admixed Latin American population.Methods: A cross-sectional study was carried out with adults from the Colombian Caribbean Coast, selected in urban clusters and work places through a stratified sampling to include diverse ages and socioeconomic groups. Blood pressure and waist circumference were registered. Serum concentrations of glucose, triglycerides, and high-density lipoprotein cholesterol were measured from an 8-hr fasting whole-blood sample. Two previously analyzed CAV1 single nucleotide polymorphisms were genotyped (rs926198 and rs11773845). A logistic regression model was applied to estimate the associations. An admixture adjustment was performed through a Bayesian model.Results: A total of 605 subjects were included. rs11773845 was associated with hypertriglyceridemia [odds ratio (OR) = 1.33, p = 0.001] and the metabolic syndrome (OR = 1.53, p = 0.02). When admixture adjustment was performed these genetic associations preserved their statistical significance. There were no significant associations between rs926198 and metabolic traits.Conclusions: The CAV1 variation rs11773845 was found to be consistently associated with high serum triglycerides and the metabolic syndrome. This is the first report of a relationship between CAV1 variants and serum triglycerides in Latin America.

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Section: Methodsmentioning

confidence: 99%

“…This approach has been previously applied by the authors in studies with Caribbean populations. 36 , 37 …”

Section: Methodsmentioning

confidence: 99%

A Common Variation in the Caveolin 1 Gene Is Associated with High Serum Triglycerides and Metabolic Syndrome in an Admixed Latin American Population

Mora-García

Gómez‐Camargo

Alario

et al. 2018

Metabolic Syndrome and Related Disorders

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“…Together with most of Latin American countries, Colombia has registered a permanent elevation in frequencies of hypertriglyceridemia with notable intra-national variations in a range of prevalence that has been found as low as 19.3% and as high as 43.9% 25 , 26 . In Cartagena de Indias, on the Colombian Caribbean Coast, high serum triglycerides were found in 38.2% of women 27 , and between 67.7% and 77.8% of the general population 28 , which represents one of the highest national frequencies.…”

Section: Introductionmentioning

confidence: 99%

Frequency of common polymorphisms in Caveolin 1 (CAV1) gene in adults with high serum triglycerides from Colombian Caribbean Coast.

et al. 2017

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Background: Caveolin 1 gene (CAV1) has been associated with insulin resistance, metabolic syndrome and hypertension in humans. Also, it has been related to high serum triglycerides in rodents, however there is little evidence of this relation in humans. Aim: To describe frequencies of common variations in CAV1 in adults with high serum triglycerides.Methods: A case-control study was carried out with adults from Colombian Caribbean Coast. A whole blood sample was employed to measure serum concentrations of triglycerides, glucose, total cholesterol and HDLc. Six common Single Nucleotide Polymorphism (SNP) in CAV1 were genotyped (rs926198, rs3779512, rs10270569, rs11773845, rs7804372 and rs1049337). Allelic and genotypic frequencies were determined by direct count and Hardy-Weinberg Equilibrium (HWE) was assessed. Case and control groups were compared with null-hypothesis tests.Results: A total of 220 cases and 220 controls were included. For rs3779512 an excess in homozygotes frequency was found within case group (40.4% (GG), 41.3% (GT) and 18.1% (TT); Fis=0.13, p=0.03). Another homozygotes excess among case group was found in rs7804372 (59.5% (TT), 32.3% (TA) and 8.2% (AA); Fis= 0.12, p= 0.04). In rs1049337, cases also showed an excess in homozygotes frequency (52.7% (CC), 35.0% (CT) and 12.3% (TT); Fis= 0.16, p= 0.01). Finally, for rs1049337 there were differences in genotype distribution between case and control groups (p <0.05).Conclusion: An increased frequency of homozygote genotypes was found in subjects with high serum triglycerides. These findings suggest that minor alleles for SNPs rs3779512, rs7804372 and rs1049337 might be associated to higher risk of hypertriglyceridemia.

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“…Las variables medidas fueron: demográficas (edad, sexo, nivel educativo, estatus socioeconómico), clínicas (estado nutricional, circunferencia abdominal, hipertensión arterial, tabaquismo, etilismo, sedentarismo, tipo de DM tratamiento antidiabético) y laboratoriales (glucemia basal, HbA1c). Se consideró una circunferencia abdominal normal si <102 cm en hombres y <88 cm (14,19,21) en mujeres .…”

Section: Materials Y Métodosunclassified

“…Int. marzo 2019; 6 (1):[21][22][23][24][25][26][27][28][29][30] Control glucémico de pacientes diabéticos en dos Unidades de Salud Familiar, Paraguay, 2018. Estudio piloto…”

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Glycemic control of diabetic patients in two Family Health Units, Paraguay, 2018. Pilot study

Gabetta

Amarilla

Rivelli

et al. 2019

Rev. virtual Soc. Parag. Med. Int

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RESUMENIntroducción: la diabetes mellitus (DM) es una enfermedad prevalente en el Paraguay y el tratamiento adecuado exige un control glucémico estricto. Objetivos: determinar la frecuencia de control glucémico adecuado en diabéticos de tres Unidades de Salud Familiar de Areguá, Paraguay. Metodología: diseño observacional, prospectivo que incluyó a varones y mujeres adultos, portadores de DM en tres Unidades de Salud Familiar de Areguá y Asunción, Paraguay, en 2018. Se midieron variables antropométricas, clínicas y laboratoriales. La glucemia en ayunas fue obtenida por glucómetro. Resultados: se incluyó a 111 diabéticos, 97% de tipo 2. La edad media fue 62±9 años y predominó el sexo femenino (70%). La frecuencia de diabéticos con hemoglobina glicada <7% fue 56%. La preobesidad y obesidad juntas se observaron en 71%. La comorbilidad más frecuente fue la hipertensión arterial (87%). El mal control glucémico se asoció significativamente al sedentarismo y bajo ingreso económico. Conclusiones: el control glucémico adecuado determinado por la hemoglobina glicada fue 56%. Se requieren estudios en mayores muestras para determinar las causas de falta de control glucémico en los diabéticos de las Unidades de Salud Familiar. ABSTRACT Introduction: Diabetes mellitus (DM) is a prevalent disease in Paraguay and proper treatment requires strict glycemic control. Objectives: To determine the frequency of adequate glycemic control in diabetics of three Family Health Units in Areguá, Paraguay.Methodology: Observational, prospective design that included adult men and women, carriers of DM in three Family Health Units of Areguá and Asunción, Paraguay in 2018. Anthropometric, clinical and laboratorial variables were measured. Fasting blood glucose was obtained by a glucometer. Results: One hundred eleven diabetics were included, 97% of type 2. The average age was 62±9 years and the female sex predominated (70%). The frequency of diabetics with glycated hemoglobin <7% was 56%. The pre-obesity and obesity together were observed in 71%. The most frequent comorbidity was arterial hypertension (87%). Poor glycemic control was significantly associated with sedentary lifestyle and low income. Conclusions: The adequate glycemic control determined by the glycated hemoglobin was 56%. Studies in larger samples are required to determine the causes of lack of glycemic control in diabetics of Family Health Units.

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Concordancia entre cinco definiciones de síndrome metabólico. Cartagena, Colombia

Abstract: Significant agreement was found between the four most recent guidelines. Abdominal obesity cut-off points might support differences agreement differences.

Cited by 16 publications

References 29 publications

A Common Variation in the Caveolin 1 Gene Is Associated with High Serum Triglycerides and Metabolic Syndrome in an Admixed Latin American Population

A Common Variation in the Caveolin 1 Gene Is Associated with High Serum Triglycerides and Metabolic Syndrome in an Admixed Latin American Population

Frequency of common polymorphisms in Caveolin 1 (CAV1) gene in adults with high serum triglycerides from Colombian Caribbean Coast.

Glycemic control of diabetic patients in two Family Health Units, Paraguay, 2018. Pilot study

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