Concurrence of Circumscribed Morphea and Segmental Vitiligo: A Case Report

Park, Hyun Sun; Cho, Soyun; Yoon, Hyun Sun

doi:10.5021/ad.2018.30.6.708

Cited by 4 publications

(4 citation statements)

References 19 publications

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“…11 different reports were found which makes it by far the most frequently observed comorbidity [57.1% (12/21 patients) of reported patients with autoimmune comorbidities]. In most cases, the morphea lesions affected the same body area as the SV, although multifocal morphea was also documented (36)(37)(38)(39)(40)(41)(42)(43)(44)(45)(46). Cases with lichen striatus are interesting because of the striking similar pathogenesis (48) (Figure 1).…”

Section: Cases Of Segmental Vitiligo Displaying Additional Skin Disormentioning

confidence: 99%

Autoimmunity in Segmental Vitiligo

et al. 2020

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The autoimmune basis of segmental vitiligo (SV) has only recently been recognized. Systemic autoimmune diseases are less frequently associated compared to non-segmental vitiligo (NSV), but localized skin disordersin particular linear morpheahave been repeatedly observed in patients with SV. The inflammatory response is documented on a clinical level with cases displaying erythematous borders or a hypochromic stage, on a histopathological level with predominantly CD8 lymphocytes migrating toward the basal layer and by flow cytometry demonstrating the antimelanocyte specificity of these cytotoxic T cells. The increased risk for halo naevi and NSV in these patients further underline the immunemediated mechanisms of SV. Nonetheless, the localized and unique distribution pattern points to somatic mosaicism. This places SV in a category of similar diseases such as lichen striatus, blaschkitis, linear lupus erythematosus, and linear scleroderma where an immune reaction against genetically mutated skin cells is believed to be the underlying cause. All these disorders are characterized by a young age of onset, a temporary disease activity with spontaneous resolution, limited response to treatment, and often long-term sequelae. Although challenging, genetic research proving this genetic mosaicism could offer crucial insights into the pathogenesis of both segmental and non-segmental vitiligo.

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Section: Cases Of Segmental Vitiligo Displaying Additional Skin Disormentioning

confidence: 99%

Autoimmunity in Segmental Vitiligo

et al. 2020

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“…A review of the literature revealed an additional nine pediatric cases with the cooccurrence of segmental vitiligo and morphea for a total of 10 cases, including the case described in this report (Table 1). [5][6][7][8][9][10][11][12] The median age at diagnosis was 10 (range 8-18 years). Six out of 10 of the cases were female.…”

Section: Discussionmentioning

confidence: 99%

The co‐occurrence of segmental vitiligo and linear morphea in a pediatric patient and a review of the literature

Kahle

Rohr

Shah

2022

Pediatric Dermatology

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Linear morphea and segmental vitiligo are both autoimmune diseases that are observed in the pediatric population, with rare reports of their co-existence. We describe a case of linear morphea and segmental vitiligo with an overlapping distribution in a pediatric patient and review the literature. Including our own case, we summarize 10 cases of co-occurring segmental vitiligo and morphea in pediatric patients; most of these lesions follow a blaschkolinear distribution, and none of the patients had autoimmune thyroid disease. Although uncommon, the coexistence of segmental vitiligo and linear morphea within lines of Blaschko can occur, and this case suggests that linear morphea and segmental vitiligo may be disorders related to genetic mosaicism.

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“…Brazilian Journal of Health Review, Curitiba, v. 7, n. 1, p. 2612-2620, jan./fev., 2024 A Esclerodermia ou Esclerose Sistêmica é uma doença sistêmica, heterogênea e complexa cuja patologia envolve inflamação e fibrose da pele e tecidos extracutâneos. 3,7 Embora a causa ainda não seja totalmente esclerecida, acredita-se que fatores genéticos, combinado à um evento desencadeante primário estejam envolvidos na gênese da doença, levando à anormalidades das células endoteliais e inflamação perivascular.…”

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“…As hipóteses incluem mosaicismo cutâneo e atuação auto imune. Tem se a hipótese de que durante a embriogênese há exposição a gatilho que ativaria a auto imunidade, que causaria o desenvolvimento de esclerodermia e vitiligo 3,12.…”

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Simultaneous occurrence of linear scleroderma and segmental vitiligo Ipsilateral: association with mosaicism?

Machado,

Rezende,

Quimquim

et al. 2024

Braz. J. Hea. Rev.

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O Vitiligo e a Esclerodermia são dermatoses distintas, que são marcadas por lesões cutâneas, de etiologia primariamente autoimune e patogênese incerta. Raros relatos descrevem a ocorrência simultânea de ambas afecções, sugerindo uma fisiopatologia comum provável, mas ainda indefinida. Acredita-se que a ocorrência de ambas as doenças pode resultar de mosaicismo genético, com apresentações unilaterais. Neste trabalho relatamos um caso raro e em criança do sexo feminino portadora de Vitiligo e Esclerodermia concomitantes e de acometimento ipsilateral e discutir uma possível associação entre as duas doenças.

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Concurrence of Circumscribed Morphea and Segmental Vitiligo: A Case Report

Cited by 4 publications

References 19 publications

Autoimmunity in Segmental Vitiligo

Autoimmunity in Segmental Vitiligo

The co‐occurrence of segmental vitiligo and linear morphea in a pediatric patient and a review of the literature

Simultaneous occurrence of linear scleroderma and segmental vitiligo Ipsilateral: association with mosaicism?

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