Concurrence of Inflammatory Bowel Disease and Multiple Sclerosis

Kimura, Keiko; Hunter, Samuel F.; Thollander, Mikael; Loftus, Edward V.; Melton, L. Joseph; O’Brien, Peter C.; Rodriguez, Moses; Phillips, Sidney F.

doi:10.4065/75.8.802

Cited by 96 publications

(69 citation statements)

References 27 publications

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“…5 In addition, a number of studies have demonstrated an increased prevalence of demyelinating diseases, including MS, in patients with IBD. 9,10,[12][13][14][15][16] In a large retrospective study evaluating comorbidities in patients with CD, 0.5% of the patients had also been diagnosed with MS, while the estimated prevalence of MS in the general population is about 0.1%. 14 Two other large register-based surveys also showed an elevated risk of MS in IBD patients as compared with a matched control group.…”

Section: Discussionmentioning

confidence: 99%

Acute CNS white matter lesions in patients with inflammatory bowel disease

Lau

Vries

Woude

et al. 2009

Inflammatory Bowel Diseases

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Section: Discussionmentioning

confidence: 99%

Acute CNS white matter lesions in patients with inflammatory bowel disease

Lau

Vries

Woude

et al. 2009

Inflammatory Bowel Diseases

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“…These associated diseases include Turner's syndrome, 7 and cystic fibrosis 8 as well as complex autoimmune genetic diseases including ankylosing spondylitis (especially in conjunction with the HLA-B27 haplotype), psoriasis, 9 and multiple sclerosis. 10 Recently, Cattan et al 11 reported a more frequent and more severe inflammatory bowel disease in French, non-Ashkenazi Jewish, families with at least one familial Mediterranean fever (FMF) patient. Fidder et al 12 reported that CD appears to be more prevalent in individuals with FMF and presents later than in individuals without FMF.…”

Section: Introductionmentioning

confidence: 99%

Prevalence and significance of mutations in the familial Mediterranean fever gene in patients with Crohn's disease

et al. 2004

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The concurrence of Crohn's disease (CD) and familial Mediterranean fever was repeatedly reported. In this study we determined the distribution and contribution of MEFV gene mutations to CD susceptibility and clinical heterogeneity. An Israeli cohort of 209 CD patients (120 men and 89 women) was investigated for mutations in the MEFV gene. A detailed chart review, interview and physical examination were used to determine sociodemographic and clinical characteristics. MEFV and NOD2/ CARD15 genotypes were analyzed in all patients and a genotype-phenotype correlation analysis was undertaken. The results of this study do not implicate MEFV mutations as major modifiers in CD. However, the E148Q MEFV variant was associated with susceptibility to perianal disease. More specifically, 19% (9/47) of CD patients with perianal disease carried the E148Q mutation compared to 6.7% (11/162) of CD patients without perianal involvement (OR 3.26, 95% CI 1.2-8.8, P ¼ 0.02). Although, for all mutations taken together, the prevalence of MEFV gene mutations among CD patients and controls was similar, the hypothesis that E148Q mutation modulates the phenotypic expression of CD is corroborated by the results of this study and needs to be further evaluated.

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“…Other groups of investigators have also documented demyelinating processes, seizures, encephalopathy, restless legs syndrome, sensorineural hearing loss, sacral nerve involvement and a cauda equina syndrome in patients with inflammatory bowel disease [22][23][24][25][26][27][28].…”

Section: Polyneuropathy In Crohn Diseasementioning

confidence: 99%