Concurrent Antisolvent Electrospraying: A Novel Continuous Crystallization Technique

Elusive Seed Formation via Electrical Confinement: Control of a Novel Cocrystal in Cooling Crystallization

“…Electrospraying is a unique crystallization method that can produce elusive crystal seeds in an unconventional way. ,, We hypothesize that the electroconfined environment allows a stabilization of the interaction between the APIs, effectively reducing the probability for hydrogen bond formation. As described by Etter’s hydrogen bond formation rules, the presence of good proton donors and proton acceptors is key for hydrogen bond formation.…”

“…Figure displays an illustration of the electrospray set up. Previous work has highlighted the ability to produce polymorphs and cocrystals by this method. ,, …”

“…Previous work has highlighted the ability to produce polymorphs and cocrystals by this method. 4,19,20 This study expands on the capability of electrospraying and highlights its use to produce elusive crystal seeds in an unconventional way. In particular, it was discovered that electrospraying was able to form a novel paracetamol (PCM)− metacetamol (MCM) cocrystal.…”

Complex of nanocarriers based on the metal polyphenol network: multi-modal synergistic inhibition of tumor cell proliferation by inducing ferroptosis and photodynamic effect

“…Preparation and characterization of SRF@Fe III TA and SRF@Fe III TA-NAPP SRF nanocrystals were prepared by adding SRF (50 mL, 40 mg mL À1 , methanol) into 20 mL of ultrapure water under ultrasonic according to the anti-solvent precipitation method. [20][21][22][23] Then, TA (100 mL, 40 mg mL À1 , ultrapure water) and FeCl 3 Á6H 2 O (50 mL, 10 mg mL À1 , in ultrapure water) were added immediately, after ultrasonic reaction for 5 minutes, the obtained product was collected by centrifuge at 8000 rpm for 15 min and washed 3 times with ultrapure water. NAPP (400 mL, 10 mg mL À1 , ultrapure water) was added to the above SRF@Fe III TA solution, then stirred for 10 minutes (250 rpm), centrifuged and washed 3 times with ultrapure water.…”