Concurrent brain structural and functional alterations in patients with migraine without aura: an fMRI study

Li, Zhengjie; Zhou, Jun; Lan, Lei; Cheng, Shirui; Gong, Qiyong; Wintermark, Max; Zeng, Fang; Liang, Fanrong

doi:10.1186/s10194-020-01203-5

Cited by 40 publications

(22 citation statements)

References 55 publications

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“…A study performed by Liang, F research showed the regional homogeneity change in migraine without aura patients using fMRI. 45 Linde K from the Technical University Munich had the highest number of co-citations. Moreover, Liu L, Li B, Xu XB, and Qu ZY were newly, but highly published authors in acupuncture on migraine research in recent years.…”

Section: Discussionmentioning

confidence: 96%

A Bibliometric Analysis of Research Trends of Acupuncture Therapy in the Treatment of Migraine from 2000 to 2020

Zhao¹,

Guo²,

Song³

et al. 2021

JPR

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Background: Migraine is the second-leading cause of disability worldwide. It is often characterized by attacks of severe, mostly unilateral, pulsating headache associated with symptoms such as photophobia, phonophobia, nausea, vomiting, and cutaneous allodynia. Acupuncture therapy has been used worldwide for the treatment of migraine. However, no visual bibliometric analysis has been conducted on the effects of acupuncture on migraine over the past 20 years. Therefore, this study aimed to explore the current status and trends on the use of acupuncture in the treatment of migraine from 2000 to 2020. Purpose: The objective of this study is to identify the current status and emerging trends of the global use of acupuncture on migraine from 2000 to 2020 using CiteSpace and VOSviewer. Methods: Web of Science databases were searched for publications related to acupuncture therapy for treating migraine between 2000 and 2020. CiteSpace and VOSviewer were used to analyze the number of publications per year, countries, institutions, authors, journals, references, and keywords. Results: A total of 572 publications were included in the final analysis. The total number of publications has continued to increase with some fluctuations over the past 20 years. The most productive country and institution in this field were the USA, and Chengdu University of Traditional Chinese Medicine, respectively. The most active and cited authors were Liang FR and Linde K, respectively. Cephalalgia was the most productive, cited, and co-cited journal. The Linde K ( 2005) had the highest co-citation, citation number and centrality. The keywords "migraine" ranked first in frequency. The common type of migraine (tension-type headache), research method (randomized controlled trial, multicenter, double-blind), acupuncture's role (prophylactic, quality of life, pain), and evaluation (meta-analysis, systematic review) were the hotspots and frontier trends of acupuncture therapy on migraine between 2000 and 2020. Conclusion:The present study examined the research-related trend in acupuncture therapy on migraine using bibliometric methods and identified the statement and research frontiers over the past two decades. This may help researchers to identify potential hotspots and new directions for future research in this field.

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Section: Discussionmentioning

confidence: 96%

A Bibliometric Analysis of Research Trends of Acupuncture Therapy in the Treatment of Migraine from 2000 to 2020

Zhao¹,

Guo²,

Song³

et al. 2021

JPR

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“…Moreover, many neuroimaging studies of migraine have focused solely on changes in brain structure or functional architecture ( Schwedt et al, 2015 ; Jia and Yu, 2017 ; Yu et al, 2021 ; Zhang et al, 2021b ). A more vital issue that has not been researched is whether and how the observed structural alterations are associated with functional deficits in migraine ( Li et al, 2020 ). Therefore, investigating both structural and functional changes in one sample can clarify the neural mechanisms of MM and guide the choice of treatment options.…”

Section: Introductionmentioning

confidence: 99%

Brain structural and functional changes during menstrual migraine: Relationships with pain

Wang

Yin

Wang

et al. 2022

Front. Mol. Neurosci.

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ObjectivesMenstrual migraine (MM) is a special type of migraine associated with the ovarian cycle, which imposes a marked burden on female patients. However, the pathogenesis of MM is not completely understood. We investigated gray matter volume (GMV) and functional connectivity (FC) alterations in patients with MM to explore whether there are changes in resting-state FC (rsFC) in brain regions with structural GMV abnormalities and investigated their relevance to pain and concomitant symptoms.MethodsSeventy-five patients with MM and 54 female healthy controls underwent functional magnetic resonance imaging and examination. The patients completed a patient’s headache diary, which included the frequency of migraine attacks, a visual analog scale for pain, a self-rating anxiety scale, and a self-rating depression scale. We used voxel-based morphometry (VBM) to examine the GMV differences between the MM and healthy control groups. The identified brain areas were selected as seeds to assess functional changes in the MM group. Correlation analysis between the altered VBM/rsFC and clinical outcomes was performed.ResultsCompared with healthy controls, patients with MM showed decreased GMV in the right anterior cingulum cortex (ACC) and increased GMV in the right superior parietal cortex. Pearson’s correlation analysis illustrated that only GMV in the right ACC was associated with visual analogue scale pain scores in the MM group. RsFC with the ACC as the seed showed that patients with MM exhibited increased FC between the ACC and the left inferior temporal gyrus, bilateral angular gyrus, and right precuneus. Correlation analysis showed that the change in FC between the right ACC and the right precuneus was positively correlated with headache frequency, and the change in FC between the right ACC and the right angular gyrus was positively correlated with the depression score.ConclusionOur results suggested that the ACC may be an important biomarker in MM, and its structural and functional impairments are significantly associated with the severity of pain and pain-related impairment of emotion in patients with MM. These findings demonstrated that headache-associated structural and functional abnormalities in the ACC may can provide integrative evidence on the physiological mechanisms of MM.

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“…Resting-state functional MRI is an imaging technique with great promise in examining coordinated activity between different brain regions, in the absence of any stimulation or tasks [ 5 ]. Utilizing this approach, multiple brain structures involved in the processing of pain, such as the hypothalamus, periaqueductal gray matter, hippocampus, amygdala, insula, basal ganglia, thalamus, sensorimotor and visual cortex, have been revealed to present atypical functional connectivity (FC) in migraine patients during the interictal phase [ 6 , 7 , 8 , 9 ]. Furthermore, several imaging studies on migraines have reported disrupted connectivity within or between resting-state networks, including the salience network, frontoparietal network, and default mode network (DMN) [ 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Propagation Structure of Intrinsic Brain Activity in Migraine without Aura

Dai

Xiong

et al. 2022

Brain Sciences

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Previous studies have revealed highly reproducible patterns of temporally lagged brain activity in healthy human adults. However, it is unknown whether temporal organization of intrinsic activity is altered in migraines or if it relates to migraine chronification. In this resting-state functional magnetic resonance imaging study, temporal features of intrinsic activity were investigated using resting-state lag analysis, and 39 episodic migraine patients, 17 chronic migraine patients, and 35 healthy controls were assessed. Temporally earlier intrinsic activity in the hippocampal complex was revealed in the chronic migraine group relative to the other two groups. We also found earlier intrinsic activity in the medial prefrontal cortex in chronic compared with episodic migraines. Both migraine groups showed earlier intrinsic activity in the lateral temporal cortex and sensorimotor cortex compared with the healthy control group. Across all patients, headache frequency negatively correlated with temporal lag of the medial prefrontal cortex and hippocampal complex. Disrupted propagation of intrinsic activity in regions involved in sensory, cognitive and affective processing of pain may contribute to abnormal brain function during migraines. Decreased time latency in the lateral temporal cortex and sensorimotor cortex may be common manifestations in episodic and chronic migraines. The temporal features of the medial prefrontal cortex and hippocampal complex were associated with migraine chronification.

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Concurrent brain structural and functional alterations in patients with migraine without aura: an fMRI study

Cited by 40 publications

References 55 publications

A Bibliometric Analysis of Research Trends of Acupuncture Therapy in the Treatment of Migraine from 2000 to 2020

A Bibliometric Analysis of Research Trends of Acupuncture Therapy in the Treatment of Migraine from 2000 to 2020

Brain structural and functional changes during menstrual migraine: Relationships with pain

Propagation Structure of Intrinsic Brain Activity in Migraine without Aura

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