Concurrent chemoradiotherapy combined with enteral nutrition support: a radical treatment strategy for esophageal squamous cell carcinoma patients with malignant fistulae

Ma, Li; Luo, Guangyu; Ren, Yu; Qiu, Bo; Yang, Hong; Xie, Chun Xia; Liu, Song Ran; Liu, Shi Liang; Chen, Zhao Lin; Li, Qun; Fu, Jianhua; Liu, Meng Zhong; Hu, Yong; Ye, Wen Feng; Liu, Hui

doi:10.1186/s40880-016-0171-6

Cited by 21 publications

(21 citation statements)

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“…Nutritional status has been closely linked to cancer mortality. 7 , 8 Recently, studies have proved that several nutrition-based indices, such as the prognostic nutritional index (PNI), body mass index (BMI), serum albumin, and preoperative body weight loss, have important prognostic value across varied malignancies, including GC. 9 – 12 A study of 1,249 cases from Chen et al found that a low BMI might be associated with poorer survival among patients with stage III–IV GC.…”

Section: Introductionmentioning

confidence: 99%

Gastric cancer, nutritional status, and outcome

Liu¹,

Qiu²,

Kong³

et al. 2017

OTT

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BackgroundWe aim to investigate the prognostic value of several nutrition-based indices, including the prognostic nutritional index (PNI), performance status, body mass index, serum albumin, and preoperative body weight loss in patients with gastric cancer (GC).Materials and methodsWe retrospectively analyzed the records of 1,330 consecutive patients with GC undergoing curative surgery between October 2000 and September 2012. The relationship between nutrition-based indices and overall survival (OS) was examined using Kaplan–Meier analysis and Cox regression model.ResultsFollowing multivariate analysis, the PNI and preoperative body weight loss were the only nutritional-based indices independently associated with OS (hazard ratio [HR]: 1.356, 95% confidence interval [CI]: 1.051–1.748, P=0.019; HR: 1.152, 95% CI: 1.014–1.310, P=0.030, retrospectively). In stage-stratified analysis, multivariate analysis revealed that preoperative body weight loss was identified as an independent prognostic factor only in patients with stage III GC (HR: 1.223, 95% CI: 1.065–1.405, P=0.004), while the prognostic significance of PNI was not significant (all P>0.05). In patients with stage III GC, preoperative body weight loss stratified 5-year OS from 41.1% to 26.5%. When stratified by adjuvant chemotherapy, the prognostic significance of preoperative body weight loss was maintained in patients treated with surgery plus adjuvant chemotherapy and in patients treated with surgery alone (P<0.001; P=0.003).ConclusionPreoperative body weight loss is an independent prognostic factor for OS in patients with GC, especially in stage III disease. Preoperative body weight loss appears to be a superior predictor of outcome compared with other established nutrition-based indices.

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Section: Introductionmentioning

confidence: 99%

Gastric cancer, nutritional status, and outcome

Liu¹,

Qiu²,

Kong³

et al. 2017

OTT

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“…In addition to tumor behavior and inflammation, the patient's nutritional status also has been closely linked to cancer prognosis. [ 17 ] Moreover, the presence of systemic inflammation is proposed to be pathogenic in the development of cancer-related malnutrition. [ 18 ] Nutritional impairment in turn is correlated with poor immunological functions, and shorter survival.…”

Section: Introductionmentioning

confidence: 99%

Inflammation-nutrition scope predicts prognosis of early-stage hepatocellular carcinoma after curative resection

Zhu

Li²,

Yang³

et al. 2017

Medicine

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“…There is increasing evidence that cancer-related malnutrition is a common but often unrecognized problem[ 47 ], and the prognosis of cancer is closely linked to nutritional status[ 48 - 50 ]. Several potential mechanisms have been hypothesized for their relationship.…”

Section: Discussionmentioning

confidence: 99%

Comparison of prognostic factors in different age groups and prognostic significance of neutrophil-lymphocyte ratio in patients with gastric cancer

Huang

Han

2020

WJGO

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BACKGROUND Gastric cancer (GC) is one of the most common malignant tumors in the world. Although in recent years tremendous progress has been made in its early detection, the postoperative overall survival (OS) of GC patients remains extremely low. A number of studies have shown that age, to varying degrees, affects the prognosis of patients with GC. Therefore, this study retrospectively analyzed the clinical and pathologic data of patients with GC to explore the differences in the clinical characteristics and prognostic factors in different age groups. AIM To explore the difference in clinicopathological characteristics and prognostic factors in GC patients in different age groups. METHODS In this retrospective study, we analyzed 1037 GC patients admitted to Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine from May 2010 to January 2013. The patients were divided into two groups based on age: Younger group (less than 70 years old) and older group (no less than 70 years old). In the younger group, we subdivided the patients in two subgroups by a cut-off value of 45 years. The clinical features and prognostic factors were analyzed in both groups. Subsequently, we retrieved studies that evaluated the predictive role of neutrophil-lymphocyte ratio (NLR) by searching two medical databases, PubMed and EMBASE, to conduct a meta-analysis. Random-effects model was used to pool the data. RESULTS In the retrospective study, the mean OS time of the younger group (64.7 mo) was significantly longer than that of the older group (48.1 mo) ( P < 0.001). Among patients under 70 years of age, hospitalization time, tumor–node–metastasis (TNM) stage, vascular invasion, and preoperative low pre-albumin were independently associated with OS ( P < 0.005). In patients aged 70 years and above, TNM stage, esophageal invasion, histological type, and preoperative NLR were independent factors for OS ( P < 0.05). The OS of these older patients was also significantly shorter ( P < 0.05). In the meta-analysis, 19 retrieved studies included a total of 8312 patients, among whom 3558 had elevated NLR values. The results showed that high NLR value was a risk factor for the prognosis of GC ( P < 0.01). CONCLUSION The OS of elderly patients is significantly worse than that of younger patients. There are significant differences in clinicopathological characteristics and prognostic factors between younger and older patients. NLR is a convenient, inexpensive, and reproducible marker that can be used as an important predictor of the prognosis of GC.

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Concurrent chemoradiotherapy combined with enteral nutrition support: a radical treatment strategy for esophageal squamous cell carcinoma patients with malignant fistulae

Cited by 21 publications

References 28 publications

Gastric cancer, nutritional status, and outcome

Gastric cancer, nutritional status, and outcome

Inflammation-nutrition scope predicts prognosis of early-stage hepatocellular carcinoma after curative resection

Comparison of prognostic factors in different age groups and prognostic significance of neutrophil-lymphocyte ratio in patients with gastric cancer

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