Concurrent endocrine neoplasias in dogs and cats: a retrospective study (2004–2014)

Beatrice, Laura; Boretti, Felicitas S; Sieber-Ruckstuhl, Nadja S; Mueller, Claudia; Kümmerle‐Fraune, Claudia; Hilbe, Monika; Grest, Paula; Reusch, Claudia E

doi:10.1136/vr.104199

Cited by 19 publications

(27 citation statements)

References 31 publications

(71 reference statements)

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“…In case of an adrenocortical tumor (AT), imaging of the thorax is important to search for metastases and CT imaging is the method of choice. Moreover, concurrent endocrine neoplasms have been described, and dogs with spontaneous hypercortisolism caused by an AT also may have a PT . If both pituitary and adrenal lesions are present, abdominal ultrasonography leads to an incomplete diagnosis if pituitary size and ACTH secretion are not measured.…”

Section: Introductionmentioning

confidence: 99%

Concurrent pituitary and adrenocortical lesions on computed tomography imaging in dogs with spontaneous hypercortisolism

Bokhorst

Kooistra

Boroffka

et al. 2018

Veterinary Internal Medicne

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BackgroundSpontaneous hypercortisolism or Cushing's syndrome in dogs is either pituitary or adrenal dependent, but concurrent pituitary and adrenal hypercortisolism also has been reported.ObjectiveTo determine how often concurrent pituitary and adrenal lesions are present in dogs with spontaneous hypercortisolism.AnimalsTwo hundred one client‐owned dogs with spontaneous hypercortisolism.MethodsRetrospective study. Pre‐ and post‐contrast computed tomography (CT) scans of the pituitary and adrenal glands were performed in dogs with confirmed hypercortisolism.ResultsIn dogs with dexamethasone‐suppressible hypercortisolism (122/201), 78 dogs (64%) had an enlarged pituitary gland (median pituitary height/brain area [P/B], 0.43 × 10−2 mm−1; range, 0.32‐1.21 × 10−2 mm−1). Two of these 78 dogs had concurrent adrenal lesions. In the remaining dogs (44/122; 36%), the pituitary gland was not enlarged. In the dexamethasone‐resistant group (79/201), the pituitary gland was enlarged in 47 dogs (59%; median P/B, 0.57 × 10−2; range, 0.32‐1.50 × 10−2 mm−1). Eight of these 47 dogs (17%) had concurrent adrenal lesions. In the remaining 32 dexamethasone‐resistant dogs (41%), the pituitary gland was not enlarged. Among them, 27 dogs had adrenal lesions and suppressed ACTH concentrations consistent with adrenal‐dependent hypercortisolism and 5 dogs were diagnosed with pituitary‐dependent hypercortisolism.Conclusions and Clinical ImportanceConcurrent pituitary and adrenal lesions were present in 5% of all dogs with hypercortisolism and in 10% of the dexamethasone‐resistant dogs. Diagnostic imaging of both pituitary and adrenal glands should be included in the diagnostic evaluation of every dog with spontaneous hypercortisolism to obtain information needed for estimation of prognosis and choosing the optimal treatment.

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Section: Introductionmentioning

confidence: 99%

Concurrent pituitary and adrenocortical lesions on computed tomography imaging in dogs with spontaneous hypercortisolism

Bokhorst

Kooistra

Boroffka

et al. 2018

Veterinary Internal Medicne

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“…A ocorrência de neoplasias múltiplas já foi relatada em diferentes espécies domésticas, como gato, equino e bovino (PRIESTER, 1977). No entanto, esse tipo de apresentação tumoral é mais frequente em cães, apesar dos casos em felinos envolverem frequentemente, de forma concomitante, tumores malignos (PRIESTER, 1977;MILLER et al, 2003;BEATRICE et al, 2018).…”

Section: Discussaounclassified

“…O melanoma é frequentemente diagnosticado em casos de tumores múltiplos distintos em cães (REBHUN; THAMM, 2010). Em felinos, a ocorrência de neoplasias concomitantes é menos frequente do que em cães, e incluem a associação de adenocarcinoma nasal e adenoma tireoidiano, feocromocitoma e adenoma hipofisário acidofílico de pars distalis (BEATRICE et al, 2018), adenocarcinoma mamário e leiomioma uterino (MILLER et al, 2003). O exame citológico é de grande importância para o diagnóstico de neoplasias, por ser pouco invasivo, simples de ser realizado, rápido na determinação do diagnóstico e de baixo custo.…”

Section: Introducãounclassified

Ocorrência De Neoplasias Múltiplas Distintas Em Um Cão Weimaraner Idoso

Pinto

Gomes

Gorza

et al. 2019

Ars Vet

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Neoplasias múltiplas são relativamente comuns em cães, no entanto são escassos os relatos sobre essa condição clínica. O objetivo do presente trabalho foi relatar um caso de ocorrência de diferentes neoplasias em uma cadela da raça Weimaraner, de 13 anos de idade. O paciente foi referido devido ao histórico de recorrência de melanoma oral e ao exame físico foi constatada dispneia intensa. A radiografia do crânio revelou proliferação periosteal ativa, reabsorção óssea e aumento dos espaços periodontais, em mandíbula esquerda, sugerindo neoplasia ou processo infeccioso. Radiografias torácicas revelaram um padrão pulmonar intersticial miliar e nodular, com múltiplos nódulos radiopacos, de diferentes tamanhos, difusamente distribuídos pelos lobos, caracterizando metástase pulmonar. Devido a condição clínica e ao prognóstico desfavorável, foi realizada a eutanásia do animal. Ao exame post mortem foram identificados dois nódulos em cavidade oral, bem como, diversos nódulos nas cadeias mamárias esquerda e direita e tumor em glândula adrenal. Metástases do melanoma oral foram evidenciadas no pulmão, espaço intercostal e vesícula urinária. Durante a necropsia, realizou-se coleta aspirativa por agulha fina (CAAF) dos nódulos descritos previamente, e os achados citológicos se correlacionaram aos histopatológicos.

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“…In their study,adrenocortical and adrenomedullary markers were used to carry out histological diagnosis 10 ; Melan A, inhibin and calretinin 10-year-old Boston terrier dog presented with exercise intolerance, polyuria and polydipsia and weakness, was diagnosed with concurrent endocrine neoplasia: paraganglioma at the heart base (arrow), pheochromocytoma, pituitary adenoma and adrenocortical adenoma.…”

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confidence: 99%

“…19 While synaptophysin is a well-recognised marker for adrenal medullary cells, 11 displaying chromain granules with a silver stain (SNOBA) has been performed as well. 10 In comparison to other types of tumours associated with CEN, paragangliomas in dogs are hormonally inactive and the value of medullary markers in conirming the diagnosis by immunohistochemistry is so far unknown. In the future, immunohistochemical markers should become a routine part of histopathological evaluation of adrenal gland tumours, independently of the clinical endocrine diagnosis.…”

mentioning

confidence: 99%