Concurrent exposures to nonylphenol, bisphenol A, phthalates, and organophosphate pesticides on birth outcomes: A cohort study in Taipei, Taiwan

Huang, Yu Fang; Pan, Wen Chi; Tsai, Yen An; Chang, Chia Huang; Chen, Pei Jung; Shao, Yi shuan; Tsai, Ming-Shiun; Hou, Jia‐Woei; Lu, Chensheng; Chen, Mei Lien

doi:10.1016/j.scitotenv.2017.07.092

Cited by 75 publications

(42 citation statements)

References 47 publications

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“…While adult exposure to these chemicals is of importance, the exposure of fetuses and/or infants is of primary concern since those groups are extremely sensitive to the effects caused by phthalates with endocrine disruption properties [ 3 , 4 ]. Growing evidence suggests that in-utero exposure to phthalates may result in adverse birth outcomes, including the reduction in anogenital distance (AGD), weight and length at birth, and gestational age, as well as the increased risk of preterm delivery [ 5 , 6 , 7 , 8 ]. However, previous findings on these correlations are still controversial.…”

Section: Introductionmentioning

confidence: 99%

Meconium Exposure to Phthalates, Sex and Thyroid Hormones, Birth Size and Pregnancy Outcomes in 251 Mother–Infant Pairs from Shanghai

Jialin

et al. 2020

IJERPH

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Phthalates are hormonally active pollutants. In-utero exposure to phthalates has been reported to be associated with birth size parameters and pregnancy outcomes. However, previous reports were inconsistent. We examined the associations between meconium exposure to phthalates and the effects on birth size parameters, pregnancy outcomes and sex and thyroid hormones in 251 mother–infant pairs from a Shanghai hospital. We measured 10 metabolites of phthalates in meconium samples collected during the first 24h after delivery. Information on seven birth size parameters (birth weight, birth length, abdominal circumference, head circumference, femur length, biparietal diameter and anogenital distance) and three pregnancy outcomes (gestational diabetes, premature rupture of membrane, and premature birth) was available from the birth record. Concentrations of free testosterone, estradiol (E2), thyroid stimulating hormone, concentrations of total and free thyroxine and triiodothyronine were measured from cord blood. Multivariate linear regression and logistic regression were used to estimate associations between phthalate exposure and health outcomes. mono-iso-butylphthalate (MiBP), mono-n-butylphthalate (MnBP) and mono-2-ethyl-5-oxohexyl phthalate (MEOHP) were positively associated with birth length and femur length which seemed more obvious in female newborn; MiBP, MnBP and mono-2-ethylhexylphthalate (MEHP) were positively associated with gestational diabetes mellitus (GDM) only in mothers with male newborns; monomethyl phthalate (MMP), MiBP and MEOHP were positively associated with E2 in male newborns. This study indicates that meconium exposure to phthalates may adversely affect some fetal growth parameters and GDM with a potential gender effect.

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Section: Introductionmentioning

confidence: 99%

Meconium Exposure to Phthalates, Sex and Thyroid Hormones, Birth Size and Pregnancy Outcomes in 251 Mother–Infant Pairs from Shanghai

Jialin

et al. 2020

IJERPH

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“…It can also be formed from the anaerobic breakdown of ethoxylated alkylphenols (Araujo et al 2018). NP affects reproduction, fertility and infant size at birth (Huang et al 2017). NP has been reported severally in WWTPS and surface waters worldwide (Chokwe et al 2016;Carvalho et al 2016;Belhaj et al 2015).…”

Section: Discussionmentioning

confidence: 99%

Occurrence of selected endocrine disrupting compounds in the eastern cape province of South Africa

Farounbi

Ngqwala

2020

Environ Sci Pollut Res

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Endocrine-disrupting compounds are attracting attention worldwide because of their effects on living things in the environment. Ten endocrine disrupting compounds: 4-nonylphenol, 2,4-dichlorophenol, estrone, 17β-estradiol, bisphenol A, 4-tertoctylphenol, triclosan, atrazine, imidazole and 1,2,4-triazole were investigated in four rivers and wastewater treatment plants in this study. Rivers were sampled at upstream, midstream and downstream reaches, while the influent and effluent samples of wastewater were collected from treatment plants near the receiving rivers. Sample waters were freeze-dried followed by extraction of the organic content and purification by solid-phase extraction. Concentrations of the compounds in the samples were determined with ultra-high performance liquid chromatography-tandem mass spectrometry. The instrument was operated in the positive electrospray ionization (ESI) mode. The results showed that these compounds are present in the samples with nonylphenol > dichlorophenol > bisphenol A > triclosan > octylphenol > imidazole > atrazine > triazole > estrone > estradiol. Nonylphenol has its highest concentration of 6.72 μg/L in King Williams Town wastewater influent and 2.55 μg/L in midstream Bloukrans River. Dichlorophenol has its highest concentration in Alice wastewater influent with 2.20 μg/L, while it was 0.737 μg/L in midstream Bloukrans River. Uitenhage wastewater effluent has bisphenol A concentration of 1.684 μg/L while it was 0.477 μg/L in the downstream samples of the Bloukrans River. Generally, the upstream samples of the rivers had lesser concentrations of the compounds. The wastewater treatment plants were not able to achieve total removal of the compounds in the wastewater while runoffs and wastes dump from the cities contributed to the concentrations of the compounds in the rivers.

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“…The US National Health and Nutrition Examination Survey (NHANES) III reported that the geometric mean of urinary 4-NP level was below the LOD (0.1 ng/mL) for the US adult population [ 20 ]. On the other hand, several studies conducted in Taiwan showed that the geometric mean of urinary 4-NP concentration was 2.90–4.10 ng/mL for Taiwanese pregnant women with a mean age range of 31.0–33.4 years [ 21 , 22 , 23 , 24 ]. Given that 4-NP levels do not significantly differ by sex, the geometric mean of urinary 4-NP concentration in the Korean population is assumed to be similar to that in the Taiwanese population and much higher than that in the U.S. population.…”

Section: Discussionmentioning

confidence: 99%

Urinary Levels of 4-Nonylphenol and 4-t-Octylphenol in a Representative Sample of the Korean Adult Population

Park

Kim

2017

IJERPH

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4-Nonylphenol (4-NP) and 4-t-octylphenol (4-t-OP) are xenoestrogen compounds to which humans are exposed via contaminated food, water, and air. This study assessed the body burden of 4-NP and 4-t-OP in Koreans aged 18–69 years using data from the Korean National Human Biomonitoring Survey conducted in 2009. Based on data from 1865 representative Koreans, 83.2% and 91.8% had urinary 4-NP and 4-t-OP concentrations >0.05 ng/mL (limit of detection). Of the Korean adult population, the geometric mean urinary concentrations of 4-NP and 4-t-OP were 3.70 ng/mL (95% confidence interval (CI) = 3.20–4.27) and 0.60 ng/mL (95% CI = 0.55–0.66), respectively. Urine 4-NP concentrations were significantly associated with place of residence and smoking status, whereas urine 4-t-OP concentrations were not correlated with any of the demographic factors. These findings suggest that most Koreans have detectable levels of 4-NP and 4-t-OP in their urine and that the body burden of 4-NP, but not 4-t-OP, varies according to some demographic factors.

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Concurrent exposures to nonylphenol, bisphenol A, phthalates, and organophosphate pesticides on birth outcomes: A cohort study in Taipei, Taiwan

Cited by 75 publications

References 47 publications

Meconium Exposure to Phthalates, Sex and Thyroid Hormones, Birth Size and Pregnancy Outcomes in 251 Mother–Infant Pairs from Shanghai

Meconium Exposure to Phthalates, Sex and Thyroid Hormones, Birth Size and Pregnancy Outcomes in 251 Mother–Infant Pairs from Shanghai

Occurrence of selected endocrine disrupting compounds in the eastern cape province of South Africa

Urinary Levels of 4-Nonylphenol and 4-t-Octylphenol in a Representative Sample of the Korean Adult Population

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