Concurrent Heavy Metal Exposures and Idiopathic Dilated Cardiomyopathy: A Case-Control Study from the Katanga Mining Area of the Democratic Republic of Congo

Malamba-Lez, Didier; Tshala-Katumbay, Desiré; Bito, Virginie; Rigo, Jean-Michel; Kyandabike, Richie Kipenge; Yolola, Eric Ngoy; Katchunga, Philippe Bianga; Koba-Bora, Béatrice; Ngoy-Nkulu, Dophra

doi:10.3390/ijerph18094956

Cited by 9 publications

(4 citation statements)

References 84 publications

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“…Accidental intoxication among farm workers exposed to CuSO 4 has been reported, and toxic levels of this pesticide can lead to methemoglobinemia and death [ 48 ]. Cardiotoxicity due to exposure to Cu has been reported in zebrafish [ 5 , 16 ], and increased incidence of HF in human was associated with high Cu levels [ 17 , 18 , 19 ]. Owing to its ability to generate ROS, cardiotoxicity of Cu could be directly attributed to oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

“…Cu caused cardiotoxicity manifested by cellular stress, necrosis, and absence of heartbeat in zebrafish [ 5 , 16 ]. Studies have demonstrated an association between the exposure to high Cu concentrations and the increase in cardiovascular risk and heart failure incidence in humans [ 17 , 18 , 19 ]. Although the mechanisms underlying Cu toxicity are not fully understood, excess reactive oxygen species (ROS), oxidative stress [ 20 , 21 ], and endocrine perturbation [ 22 ] have been implicated.…”

Section: Introductionmentioning

confidence: 99%

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Nano-Curcumin Prevents Cardiac Injury, Oxidative Stress and Inflammation, and Modulates TLR4/NF-κB and MAPK Signaling in Copper Sulfate-Intoxicated Rats

et al. 2021

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Copper (Cu) is essential for a plethora of biological processes; however, its high redox reactivity renders it potentially toxic. This study investigated the protective effect of curcumin (CUR) and nano-CUR (N-CUR) against Cu cardiotoxicity, emphasizing the role of oxidative stress, TLR4/NF-κB and mitogen-activated protein kinase (MAPK) signaling and cell death in rats. Rats received 100 mg/kg copper sulfate (CuSO4), a pesticide used for repelling pests, and were concurrently treated with CUR or N-CUR for 7 days. Cu caused cardiac injury manifested by elevated serum cardiac troponin I (cTnI), creatine kinase (CK)-MB, and lactate dehydrogenase (LDH), as well as histopathological alterations. Cardiac malondialdehyde (MDA), NF-κB p65, TNF-α, and IL-6 were increased, and reduced glutathione (GSH), superoxide dismutase (SOD) and catalase were decreased in Cu-treated rats. CUR and N-CUR prevented cardiac tissue injury, decreased serum cTnI, CK-MB, and LDH, and cardiac MDA, NF-κB p65, TNF-α, and IL-6, and enhanced cellular antioxidants. CUR and N-CUR downregulated TLR4 and AP-1, and decreased the phosphorylation levels of p38 MAPK, JNK, and ERK1/2. In addition, CUR and N-CUR increased cardiac Bcl-2 and BAG-1, decreased Bax and caspase-3, and prevented DNA fragmentation. In conclusion, N-CUR prevents Cu cardiotoxicity by attenuating oxidative injury, inflammatory response, and apoptosis, and modulating TLR4/NF-κB and MAPK signaling. The cardioprotective effect of N-CUR was more potent than the native form.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Nano-Curcumin Prevents Cardiac Injury, Oxidative Stress and Inflammation, and Modulates TLR4/NF-κB and MAPK Signaling in Copper Sulfate-Intoxicated Rats

et al. 2021

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“…In another study from Peru, 18 to 35-year-old non-miners living near a mining community, 4400 m above sea level showed a mean BLL of 47.5 µg/L, while unexposed persons in Lima had a mean BLL of 20.3 µg/L [36]. Furthermore, a mean BLL of 56.5 µg/L was reported for a group of people living near a mining area of Katanga in the Democratic Republic of Congo [37]. Overall, 106 or 116 µg/L, respectively, were reported from a study performed in Zambia on adult mothers and fathers of a mining town [14].…”

Section: Adults Living In the Vicinity Of Mining Sitesmentioning

confidence: 91%

Blood Lead Monitoring in a Former Mining Area in Euskirchen, Germany—Volunteers across the Entire Population

Bertram

Ramolla²,

Esser

et al. 2022

IJERPH

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After centuries of mining in the district of Euskirchen, that is, in the communities of Mechernich and Kall, the lead concentration in the soil remains high, often exceeding regulatory guidelines. To clarify the lead body burden among residents in the region, a human biomonitoring study on a voluntary basis was initiated in which the blood lead level (BLL) was assessed. A questionnaire was distributed to evaluate lead exposure routes and confounders. Overall, 506 volunteers participated in the study, of whom 7.5% were children and adolescents, 71.9% were adults from 18 to 69 years, and 19.4% were residents 70 years or older. While the BLLs in the adult population were inconspicuous, among the children and adolescents investigated, 16.7% of the children between 3 and 17 years had BLLs above the recently revised German reference values for BLL in children. These results point towards a higher lead exposure in children living in the region. The hierarchical regression analysis based on the BLL and the questionnaire revealed the significant influence of the factors age, sex, smoking, construction age of the real estate, occupancy, and intensive contact with soil on the BLL. Measures to reduce lead exposure include a focus on improved personal and domestic hygiene to minimize lead intake.

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“…Miura et al demonstrated that the lower education levels and cold or hot workplaces exhibited a significant association with the development of DCM ( 39 ). Some heavy metals were associated with DCM probability ( 40 ). Although there are still few reports on the relationship between environmental factors and DCM, it is one of the routes of disease disparity, such as the sanitary environment, and further research is required in the future.…”

Section: Dilated Cardiomyopathymentioning

confidence: 99%

Social Inequalities in Non-ischemic Cardiomyopathies

Amiya

2022

Front. Cardiovasc. Med.

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Heart failure (HF) has various characteristics, such as etiology, clinical course, and clinical characteristics. Several studies reported the clinical findings of the characteristics of non-ischemic cardiomyopathy. There have been issues with genetic, biochemical, or pathophysiological problems. Some studies have been conducted on non-ischemic cardiomyopathy and social factors, for instance, racial disparities in peripartum cardiomyopathy (PPCM) or the social setting of hypertrophic cardiomyopathy. However, there have been insufficient materials to consider the relationship between social factors and clinical course in non-ischemic cardiomyopathies. There were various methodologies in therapeutic interventions, such as pharmacological, surgical, or rehabilitational, and educational issues. However, interventions that could be closely associated with social inequality have not been sufficiently elucidated. We will summarize the effects of social equality, which could have a large impact on the development and progression of HF in non-ischemic cardiomyopathies.

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Concurrent Heavy Metal Exposures and Idiopathic Dilated Cardiomyopathy: A Case-Control Study from the Katanga Mining Area of the Democratic Republic of Congo

Cited by 9 publications

References 84 publications

Nano-Curcumin Prevents Cardiac Injury, Oxidative Stress and Inflammation, and Modulates TLR4/NF-κB and MAPK Signaling in Copper Sulfate-Intoxicated Rats

Nano-Curcumin Prevents Cardiac Injury, Oxidative Stress and Inflammation, and Modulates TLR4/NF-κB and MAPK Signaling in Copper Sulfate-Intoxicated Rats

Blood Lead Monitoring in a Former Mining Area in Euskirchen, Germany—Volunteers across the Entire Population

Social Inequalities in Non-ischemic Cardiomyopathies

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