Concurrent Illnesses in Adults with Childhood‐Onset Epilepsy: A Population‐Based 35‐Year Follow‐Up Study

Jalava, Merja; Sillanpää, Matti

doi:10.1111/j.1528-1157.1996.tb00547.x

Cited by 89 publications

(66 citation statements)

References 28 publications

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“…Furthermore, the risk of occurrence of psychiatric disorders in adult patients with childhood-onset epilepsy has been recently emphasized. [46] Similarly, the potential adverse effect of repeated seizures on the developing brain, the expectation of some developmental catch up, and the concept of young-brain equipotentiality (plasticity) that allows aggressive surger, have all been important issues in advocating early surgical treatment. [19,20,23,33,73,80] In addition, the recognition of side effects caused by anticonvulsant therapy have positively influenced the trend for alternative management strategies.…”

Section: Discussionmentioning

confidence: 99%

Surgery in epilepsy associated with focal lesions in childhood

Bourgeois¹,

Sainte‐Rose²,

Lellouch‐Tubiana³

et al. 1999

FOC

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Surgery in children with epilepsy is a new, evolving field. The important practical issues have been to define strategies for choosing the most suitable candidates, as well as the type and the optimum timing of epilepsy surgery. This study was undertaken to illustrate these points. To identify the factors that correlated with outcome, the authors analyzed a series of 200 children (aged 1–15 years, mean 8.7 years) who underwent surgery at the Hôpital Necker-Enfants Malades between 1981 and 1996. In 171 cases (85.5%) the epilepsy was medically refractory and was associated with focal cortical lesions. Surgery consisted of resection of the lesion without specifically attempting to identify and remove the "epileptogenic area." In the group of children whose seizures were medically refractory, the mean follow-up period was 5.8 years. According to Engel's classification, 71.3% of these children became seizure free (Ia), whereas 82% were in Class I. A multivariate statistical analysis revealed that among all the factors studied, the success of surgery in a patient in whom there was a good clinical-electroencephalogram-imaging correlation, depended on the patients' having undergone a minimally traumatic operation, a complete resection of the lesion, and a short preoperative seizure duration. After the surgical control of epilepsy, behavior disorders were more improved (31% of all patients) than cognitive function (25%). The patient age at onset, duration and frequency of seizures, intractability of the disease to therapy, and seizure characteristics, were correlated with cognitive, behavioral, and academic performance pre- and postoperatively. Multivariate statistical analysis revealed that cognitive dysfunction correlated highly with the duration of epilepsy prior to surgery, whereas behavioral disorders correlated more with seizure frequency. These data must be taken into account when selecting patients for surgical treatment and when deciding the timing of surgery. Early surgical intervention allows for optimum brain development.

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Section: Discussionmentioning

confidence: 99%

Surgery in epilepsy associated with focal lesions in childhood

Bourgeois¹,

Sainte‐Rose²,

Lellouch‐Tubiana³

et al. 1999

FOC

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“…One population-based case-control study found a 7-fold increased risk for and adult with depression to develop epileptic seizures, ompared to normal individuals. The risk increased to 17-fold with focal epilepsies [49]. Hesdorffer et al [100] observed the same temporal relation between depression and a first seizure, with a 6-fold increased risk.…”

Section: Pshysiopathology Bidirectional Relationmentioning

confidence: 60%

“…Most of these studies involve specific epileptic populations, in tertiary centers for attention to PWE. Community-based epidemiologic studies suggest a lifelong prevalence of psychiatric disorders in PWE, both adults and children, between 20 and 50% [13,[44][45][46][47][48][49][50][51][52]. Recently, Tellez-Zenteno et al [9] using data from the Canadian Community Health Survey, with administration of the World Mental Health Composite International Diagnostic Interview (CIDI), found a lifelong psychiatric disorder diagnosis in 35% of PWE, compared with 20% of non-epileptic individuals.…”

Section: Epidemiologymentioning

confidence: 99%

Psychiatric Comorbidities of Epilepsy: A Review

2011

Neurol Neurophysiol

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“…Meanwhile, individuals are exposed to stress factor more at old age than young individuals due to affective problems due to physical challenges, loss of self-confidence, feeling helpless, loneliness, hopelessness, inability to fulfill one's responsibilities, and social challenges such as those due to retirement, loss of productivity and economic difficulties. Jalava et al have demonstrated in their 35-year follow study that patients with epilepsy have a 4-fold increased risk of developing psychiatric disease and are sensitive to stress than normal individuals (28). On the other hand, the relationship between stress and seizures is usually accepted by clinical experience and Nancy et al have demonstrated in the work they have done that stress is a factor that triggers seizures (29).…”

Section: Discussionmentioning

confidence: 99%