Concurrent multiple morphea and neonatal lupus erythematosus in an infant boy born to a mother with SLE

Abstract

An infant boy born to a mother with systemic lupus erythematosus developed multiple morphea and annular erythematous lesions. The annular lesions appeared on his face, back, chest and extremities one month after birth and faded within 7 months. The sclerotic lesions progressed until the age of 6 months and remain on his back, chest, right cheek, the nape of the neck and left shoulder at the age of 3 years. Histological findings in the sclerotic lesions were consistent with scleroderma. Serological tests, performed at 14 months of age, were within normal limits. The mother developed acute SLE and died of cardio-renal failure 8 months after the delivery. It is highly probable that maternal factors transferred through the placenta caused the sclerotic lesions in the infant.

Pneumocystis carinii Mimicking Neonatal Lupus Erythematosus‐Related Pneumonitis

“…As in our patient, skin lesions often appear as annular erythematous plaques. Less common skin findings associated with neonatal LE include erosions, alopecia, vitiligo, cutis marmorata, telangiectasia congenita, and morphea‐like changes, none of which were present in our patient (6,17,18).…”

Coexistent Linear Scleroderma and Juvenile Systemic Lupus Erythematosus

“…Ohtaki et al (10) reported a mother with SLE whose infant boy developed multiple morpheiform and annular erythematous lesions. The annular lesions faded while the sclerotic lesions progressed.…”

Erythema Gyratum Atrophicans Transiens Neonatale: A Variant of Cutaneous Neonatal Lupus Erythematosus

“…Several authors have hypothesized that some reports of annular erythema in infancy may deal with unrecognized variants of NLE (16,18,24). Atypical features have been occasionally reported (23), such as a widespread, erythematous, macular rash with purpura and scaling, erythema multiforme, purpura secondary to thrombocytopenia, and the association of multiple morphea (25).…”