Concurrent occurrence of human and equine West Nile virus infections in Central Anatolia, Turkey: the first evidence for circulation of lineage 1 viruses

Özkul, Aykut; Ergünay, Koray; Koysuren, Aydan; Alkan, Feray; Arsava, Ethem Murat; Tezcan, Seda; Emekdaş, Gürol; Hacıoğlu, Sabri; Turan, Mahur; Us, Dürdal

doi:10.1016/j.ijid.2013.02.005

Cited by 36 publications

(37 citation statements)

References 29 publications

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“…2011 yılında ise insan ve atlarda eş zamanlı olarak görülen akut nöroinvazif WNV enfeksiyonlarında köken 1 (grup 1a) suşları tanımlanmıştır 33 . Mersin bölgesinde grubumuzun yaptığı güncel bir çalışmada, asemptomatik erişkinlerden oluşan farklı bir kohortta WNV seroprevalansı %12.1 olarak izlenmiş, çalışma grubunda viremi saptanmamış, aynı bölgede atlarda yapılan örneklemede ise nötralizan antikor pozitifl iği %8.2 olarak tespit edilmiş-tir 34 .…”

Section: Doğrulama Testleriunclassified

Flavivirus Seroepidemiology in Blood Donors in Mersin Province, Turkey

Tezcan

Kizildamar²,

Ülger³

et al. 2014

Mikrobiyol Bul

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Section: Doğrulama Testleriunclassified

Flavivirus Seroepidemiology in Blood Donors in Mersin Province, Turkey

Tezcan

Kizildamar²,

Ülger³

et al. 2014

Mikrobiyol Bul

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“…4 Recently, WNV RNA was detected in sick horses (buffy coat) and in humans (cerebrospinal fluid), and the partial nucleotide sequences of the E-gene coding region were closely related to viruses of lineage 1, clade 1a. 3 This study reports the detection of WNVinfected horses with neurologic signs in Turkey, using immunohistochemistry (IHC), in situ hybridization (ISH), and ELISA techniques. A 2-month-old female Rahvan foal from the Aegean Region of Turkey was presented for postmortem evaluation in July 2011 with a 1-week history of stagnation and posterior paralysis prior to death.…”

Section: 6mentioning

confidence: 99%

West Nile Virus Infection in Horses

et al. 2015

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This study describes the clinicopathologic findings in naturally occurring West Nile virus (WNV) infection in horses. WNV was diagnosed in a foal by immunohistochemical and in situ hybridization methods, and the presence of WNV antibodies was detected in 5 other horses with clinical signs suggestive of WNV infection. At necropsy of the foal, lymph nodes were edematous and enlarged, and the intestines showed diffuse congestion and focal hemorrhages. The most significant histologic lesions in this case were nonsuppurative meningoencephalomyelitis, particularly in the brainstem and spinal cord. Identification of viral RNA by in situ hybridization and viral antigen by immunohistochemistry was concentrated primarily in nerve fibers, glial cells, and their processes in brainstem and spinal cord and, to a lesser extent, within the cerebral hemispheres and cerebellum.

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“…36 Human cases of WNV infection were also identified in the Mesopotamia Region in 2009, Syria border of Turkey. 37 Overall, surveillance data show that few cases were reported in 2010 compared with 2011, when a total of 47 human cases of WN disease was reported in the country.…”

Section: Turkeymentioning

confidence: 99%

“…[48][49][50][51] Finally, this lineage was isolated in Turkey, specifically in Thrace, in 201234 and in central Anatolia. 36 The spatiotemporal distribution of WNV lineage 1 suggests that the virus was introduced from Africa to Europe by birds migrating through different routes (see Figure 2). In fact, microorganisms infecting birds tend to be dispersed along migration routes.…”

Section: 45mentioning

confidence: 99%

West Nile virus infection in South-eastern Europe and in the Eastern Mediterranean area

Rezza¹

2014

Journal of Microbiology and Infectious Diseases

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The West Nile virus (WNV) was identified in Uganda in 1937. This virus appeared in the Mediterranean area in the early 1950s, causing an outbreak in Egypt. Since then, WNV caused a series of outbreaks, in human and/or horses, especially in North-Africa and in the Middle East. In the last few decades, the lineage 1 of West Nile started to cause sporadic cases and outbreaks of West Nile fever and neuroinvasive disease in Southern and Eastern Europe, and a large outbreak was reported in Romania in 1997; then, sporadic cases continued to be reported in central and southern Europe for years. Since 2010, West Nile has reemerged in Europe and in the Mediterranean area. Studies of molecular epidemiology show a co-circulation of WNV lineage 1 and lineage 2 in several European countries. In particular, WNV lineage 2 appears now to be established in South-eastern Europe and in the Balkans. This suggests that WNV is continuously reintroduced in this geographical area. Specifically, the two lineages of WNV are dispersed throughout Europe after arriving through bird migration, following the western and the eastern routes. The latter route is likely to be involved in the emergence and reemergence of WNV infection in South-eastern Europe, where this viral infection represent an important public health challenge. J Microbiol Infect Dis 2014; Special Issue 1: S10-S16

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Concurrent occurrence of human and equine West Nile virus infections in Central Anatolia, Turkey: the first evidence for circulation of lineage 1 viruses

Abstract: This is the first report of acute WNV infections caused by lineage 1 strains from Turkey, in concordance with previous reports from some European and North African countries.

Cited by 36 publications

References 29 publications

Flavivirus Seroepidemiology in Blood Donors in Mersin Province, Turkey

Flavivirus Seroepidemiology in Blood Donors in Mersin Province, Turkey

West Nile Virus Infection in Horses

West Nile virus infection in South-eastern Europe and in the Eastern Mediterranean area

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