Concurrent oxytocin with dinoprostone pessary versus dinoprostone pessary in labour induction of nulliparas with an unfavourable cervix: a randomised placebo‐controlled trial

Tan, Peng Chiong; Valiapan, S D; Tay, P Y S; Omar, Siti Zawiah

doi:10.1111/j.1471-0528.2007.01384.x

Cited by 17 publications

(24 citation statements)

References 21 publications

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“…In the second study, Tan et al [9] compared dinoprostone pessary + oxytocin and placebo + oxytocin in 114 patients with an unfavorable cervix and reported that concurrent vaginal dinoprostone + intravenous oxytocin for labor induction in term women with premature rupture of membrane did not expedite delivery or improve patient satisfaction. In another study conducted by the same authors [15], 220 patients were randomized to receive either pessary + oxytocin or pessary only, and the investigators found concurrent oxytocin infusion with dinoprostone pessary did not significantly increase the vaginal delivery rate within 24 h but reduced the requirement for repeat dinoprostone and improved maternal satisfaction with the birth process. In our trial, only 19.4% of the patients in the dinoprostone group required oxytocin infusion due to unsatisfactory uterine contractions.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Low-Dose Oxytocin and Dinoprostone for Labor Induction in Postterm Pregnancies: A Randomized Controlled Prospective Study

Akay

Hızlı

Yılmaz

et al. 2012

Gynecol Obstet Invest

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Aims: The aim of this study was to compare the efficacy of oxytocin and dinoprostone in achieving successful labor induction and vaginal delivery in postterm women with an unfavorable cervix. Methods: Postterm women with an uncomplicated pregnancy and a Bishop score of ≤6 were randomized to receive either dinoprostone vaginal pessary (Propess®) or low-dose oxytocin. The primary outcomes were the length of the induction-to-delivery period and the incidence of vaginal delivery. Results: A total of 144 women were available for the analysis. The overall vaginal delivery rates were 75% (54/72) for the dinoprostone group and 80.6% (58/72; p = 0.35) for the oxytocin group; the mean induction-to-vaginal delivery interval was 13.3 and 10.3 h in the dinoprostone and the oxytocin group, respectively (p = 0.003). Uterine hyperstimulation was 7.4% compared with 6.8% (p = 0.8), and abnormal fetal heart rate was 26.4% compared with 18% (p = 0.2), respectively. Conclusion: Both oxytocin and dinoprostone seem to have similar obstetric outcomes in postterm pregnancies with an unfavorable cervix, except for a significant superiority of oxytocin for delivery in a shorter period.

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Section: Discussionmentioning

confidence: 99%

Comparison of Low-Dose Oxytocin and Dinoprostone for Labor Induction in Postterm Pregnancies: A Randomized Controlled Prospective Study

Akay

Hızlı

Yılmaz

et al. 2012

Gynecol Obstet Invest

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“…15,16 In this study the use of dinoprostone gel for induction of labour, improved the Bishop score so chances of successful induction also increased.…”

Section: Discussionmentioning

confidence: 68%

Induction of Labour in Prelabour Rupture of Membranes with or without Cervical Ripening with Prostaglandin E2

Aryal¹,

Karki

2014

J Lumbini Med Coll

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Original Research Article -------------------------------------------ABSTRACT:Objective: To compare the outcome of induction of labour with titrated dose of oxytocin with or without pre induction cervical ripening using prostaglandin E2. Methods: This is a prospective study. Sixty women with prelabour rupture of membranes (PROM) and Bishops score of less than six were randomly assigned to either immediate induction with intravenous oxytocin drip or induction with intravenous oxytocin drip preceded by cervical priming with prostaglandin E2 (PGE2) gel 0.5mg instilled intracervically. These two groups were compared regarding the mode of delivery, induction to delivery interval and maternal and neonatal morbidities. Results: Cervical priming with PGE2 resulted in lesser number of caesarean section (5 Vs. 12) and lower incidence of meconium stained liquor (n=6 Vs. n=2). Induction to vaginal delivery interval was shorter when cervical priming was done (5.4 hrs Vs 7.9 hrs). The maternal morbidity was negligible (<1%) in both the groups. The number of neonates with birth asphyxia (n=2) and the need for their resuscitation (n=2) was more in the oxytocin group but the need of antibiotics for the neonates was more in PGE2 group (5% Vs. 3%). Conclusion: Induction of labor with oxytocin, with or without cervical priming with vaginal PGE2 gel, are both reasonable options in cases of PROM, since they result in statistically non significant rates of maternal and neonatal morbidities and caesarean section. Cervical priming with prostaglandin results in higher rate of vaginal delivery and shorter induction to vaginal delivery interval and this is viewed as an advantage to the mother. Keywords: induced labor • premature rupture • oxytocin • prostaglandin • cervical ripening -------------------------------------------

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“…Because to our knowledge there was no study on sustained-release dinoprostone vaginal pessary with concurrent high-dose oxytocin infusion compared with sustained-release dinoprostone vaginal pessary followed 6 h later by high-dose oxytocin infusion for labor induction available at trial inception, power calculation was based on a study of labor induction in women with prostaglandin concurrent oxytocin compared with prostaglandin, which showed a 48.6 versus 35.9% vaginal delivery rate within 24 h [8]. Setting significance at 5%, power at 80%, and a one-to-one recruitment ratio, 234 women were required in each arm.…”

Section: Methodsmentioning

confidence: 99%

“…There are 5 studies on concurrent oxytocin infusion with prostaglandin administration for cervical ripening and labor induction [4,5,6,7,8]. Three of these studies have shown a shorter induction-to-delivery interval with concurrent oxytocin infusion with a prostaglandin agent at the initiation of labor, but the other 2 studies did not demonstrate a significantly shorter induction-to-delivery interval with concurrent oxytocin infusion [4,5,6,7,8]. However, in all of these studies the concurrent oxytocin infusion period and study populations were different.…”

Section: Introductionmentioning

confidence: 99%

Sustained-Release Dinoprostone Vaginal Pessary with Concurrent High-Dose Oxytocin Infusion Compared to Sustained-Release Dinoprostone Vaginal Pessary Followed 6 h Later by High-Dose Oxytocin Infusion for Labor Induction in Women at Term with Unfavorable Cervix: A Randomized Controlled Trial

Güngördük

Yıldırım²,

Güngördük³

et al. 2010

Gynecol Obstet Invest

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Objective: To compare the efficacy and safety of sustained-release dinoprostone vaginal pessary and concurrent high-dose oxytocin infusion with sustained-release dinoprostone vaginal pessary followed 6 h later by high-dose oxytocin infusion for cervical ripening and labor induction. Methods: A total of 500 nulliparous or multiparous women with a singleton pregnancy, Bishop score ≤4 and admitted for labor induction. Women were randomly assigned to induction of labor using intravaginal dinoprostone with concurrent high-dose oxytocin (n = 250) or intravaginal dinoprostone pessary followed 6 h later by high-dose oxytocin (n = 250). The primary outcome was the number of vaginal deliveries achieved within 24 h of labor induction. Results: Baseline characteristics of both groups were comparable. Vaginal delivery within 24 h of labor induction was significantly increased with sustained-release dinoprostone followed 6 h later by high-dose oxytocin infusion (92.8 vs. 82.0%, RR 2.82, 95% CI 1.58–5.04). There were more cesarean section deliveries in the dinoprostone with concurrent high-dose oxytocin group (16.8 vs. 6.8%, RR 0.36, 95% CI 0.20–0.65). Maternal outcomes did not differ significantly. An Apgar score of <7 at 5 min was found more often in the dinoprostone with concurrent high-dose oxytocin group (3.6%) in comparison to dinoprostone pessary followed 6 h later by high-dose oxytocin (0.8%), although this was not statistically different (RR 0.21, 95% CI 0.04–1.01). Conclusion: Sustained-release dinoprostone followed 6 h later by high-dose oxytocin infusion appears to be safer and more effective than sustained-release dinoprostone with concurrent high-dose oxytocin infusion in achieving cervical ripening and successful vaginal delivery.

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Concurrent oxytocin with dinoprostone pessary versus dinoprostone pessary in labour induction of nulliparas with an unfavourable cervix: a randomised placebo‐controlled trial

Cited by 17 publications

References 21 publications

Comparison of Low-Dose Oxytocin and Dinoprostone for Labor Induction in Postterm Pregnancies: A Randomized Controlled Prospective Study

Comparison of Low-Dose Oxytocin and Dinoprostone for Labor Induction in Postterm Pregnancies: A Randomized Controlled Prospective Study

Induction of Labour in Prelabour Rupture of Membranes with or without Cervical Ripening with Prostaglandin E2

Sustained-Release Dinoprostone Vaginal Pessary with Concurrent High-Dose Oxytocin Infusion Compared to Sustained-Release Dinoprostone Vaginal Pessary Followed 6 h Later by High-Dose Oxytocin Infusion for Labor Induction in Women at Term with Unfavorable Cervix: A Randomized Controlled Trial

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