Concurrent pretibial myxedema and thyroid eye disease following mRNA COVID-19 vaccine in a patient with history of Graves’ disease

Caron, Philippe; Imbert, Philippe; Dekeister, Céline; Grunenwald, Solange

doi:10.1016/j.ando.2023.10.004

Annales d'Endocrinologie

2024

DOI: 10.1016/j.ando.2023.10.004

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Concurrent pretibial myxedema and thyroid eye disease following mRNA COVID-19 vaccine in a patient with history of Graves’ disease

Philippe Caron,

Philippe Imbert,

Céline Dekeister

et al.

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2024

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Thyroid Function in the Time of COVID-19: A Systematic Review of Disease Progression and Vaccination Effect

Zarkesh,

Sanoie,

Heydarzadeh

et al. 2024

Int J Endocrinol Metab

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Objectives: This systematic review sought to address three key questions: (1) what differences in abnormal thyroid function test results are observed between COVID-19 patients and healthy individuals? (2) How does the severity of COVID-19 infection influence the development of thyroid dysfunction? (3) What impact do COVID-19 vaccines have on thyroid function and autoimmune processes? Methods: A literature search was conducted in PubMed, Web of Science, and Scopus from December 2019 to April 2023 to identify studies on thyroid dysfunction in COVID-19 patients without pre-existing thyroid conditions. The search focused on observational and case-control studies. Results: The literature search yielded 329 reports, from which duplicates and unrelated publications were excluded. Ultimately, 21 studies met the inclusion criteria and were selected for review. A second literature search yielded 605 reports, from which 5 studies were selected for inclusion in the systematic review. Conclusions: The findings suggest that SARS-CoV-2 infection can induce transient and reversible thyroid dysfunction, possibly through direct viral effects on the thyroid gland or via indirect immune-mediated mechanisms. Clinicians should be mindful of the potential, albeit rare, thyroid-related adverse effects of COVID-19 vaccines and monitor thyroid function, particularly in high-risk individuals.

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Thyroid Function in the Time of COVID-19: A Systematic Review of Disease Progression and Vaccination Effect

Zarkesh,

Sanoie,

Heydarzadeh

et al. 2024

Int J Endocrinol Metab

View full text Add to dashboard Cite

show abstract

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Concurrent pretibial myxedema and thyroid eye disease following mRNA COVID-19 vaccine in a patient with history of Graves’ disease

Cited by 1 publication

References 15 publications

Thyroid Function in the Time of COVID-19: A Systematic Review of Disease Progression and Vaccination Effect

Thyroid Function in the Time of COVID-19: A Systematic Review of Disease Progression and Vaccination Effect

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