Concurrent reduction of glycogenolysis, glycolysis, and NA+/K+ pump activity after hemorrhagic shock

McCarter, Freda D; Evans, Jared; Luchette, FA; Friend, Lou Ann; James, J. Howard; Davis, Kenneth B.; Frame, Sharon

doi:10.1016/s0149-7944(00)00362-7

Cited by 10 publications

(10 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Stresses instantly increase the catecholamine level in serum 28–30. Epinephrine, one of the main catecholamines secreted during stress, is a potent stimulator of lactate production in skeletal muscle in vivo 31, 32 . In vivo , epinephrine activates β‐adrenoceptor and leads to the production of cAMP and activation of PKA which then activates glycogen phosphorylase, initiating glycogenolysis 31, 32.…”

Section: Resultsmentioning

confidence: 99%

“…Epinephrine, one of the main catecholamines secreted during stress, is a potent stimulator of lactate production in skeletal muscle in vivo 31, 32 . In vivo , epinephrine activates β‐adrenoceptor and leads to the production of cAMP and activation of PKA which then activates glycogen phosphorylase, initiating glycogenolysis 31, 32. Therefore, epinephrine plays an important role in the activation of glycogen phosphorylase and glycolysis in vivo .…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

α‐ and β‐Glycosyl Sulfonium Ions: Generation and Reactivity

Nokami

Shibuya

Manabe

et al. 2009

Chemistry A European J

View full text Add to dashboard Cite

Low-temperature electrochemical oxidation of thioglycosides gave glycosyl triflates from which glycosyl sulfonium ions were produced (see scheme). The latter were characterized by NMR spectroscopy and cold-spray mass spectrometry as a mixture of alpha- and beta-isomers (45:55). The alpha-glycosyl sulfonium ion exhibited higher reactivity than the beta-glycosyl sulfonium ion in the reaction with methanol, which gave a mixture of alpha- and beta-methyl glycosides (41:59).

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

α‐ and β‐Glycosyl Sulfonium Ions: Generation and Reactivity

Nokami

Shibuya

Manabe

et al. 2009

Chemistry A European J

View full text Add to dashboard Cite

show abstract

“…28 -30 Epinephrine, one of the main catecholamines secreted during stress, is a potent stimulator of lactate production in skeletal muscle in vivo. 31,32 In vivo, epinephrine activates β-adrenoceptor and leads to the production of cAMP and activation of PKA which then activates glycogen phosphorylase, initiating glycogenolysis. 31,32 Therefore, epinephrine plays an important role in the activation of glycogen phosphorylase and glycolysis in vivo.…”

Section: Resultsmentioning

confidence: 99%

“…31,32 In vivo, epinephrine activates β-adrenoceptor and leads to the production of cAMP and activation of PKA which then activates glycogen phosphorylase, initiating glycogenolysis. 31,32 Therefore, epinephrine plays an important role in the activation of glycogen phosphorylase and glycolysis in vivo. Owing to the loss of neural and hormone regulation in postmortem muscle, it is unclear whether epinephrine produced by pre-slaughter stress still plays an important role in postmortem glycolysis, and this needs further study.…”

Section: Resultsmentioning

confidence: 99%

Role of AMP‐activated protein kinase in the glycolysis of postmortem muscle

Shen¹,

Du²

2005

J Sci Food Agric

View full text Add to dashboard Cite

AMP-activated protein kinase (AMPK) is a newly identified kinase controlling energy metabolism in vivo. The objective of this study was to show the role of AMPK in postmortem glycolysis. Rapid and excessive postmortem glycolysis is directly related to the incidence of PSE (pale, soft and exudative) meat in pork, chicken and turkey, while insufficient glycolysis leads to dark cutters in beef and lamb, which causes significant loss to the meat industry. A total of 24 two-month-old C57BL/6J mice were assigned to three treatments: (1) wild-type mice without pre-slaughter treatment; (2) wild-type mice with a 2 min swim before slaughter; and (3) wild-type mice intraperitoneally injected with AICAr (50 mg kg −1 ), a specific activator of AMPK, to stimulate the activity of AMPK. In addition, 16 twomonth-old C57BL/6J mice with AMPK knockout were assigned to two treatments: (4) AMPK knockout mice without pre-slaughter treatment; and (5) AMPK knockout mice with a 2 min swim before slaughter. The longissimus dorsi muscle was sampled at 0, 1 and 24 h postmortem for pH and enzyme activity measurements. Results showed that AMPK activity had a major role in determining the ultimate muscle pH. Pre-slaughter stress induced by swimming significantly accelerated the glycogenolysis in postmortem muscle through activating glycogen phosphorylase. AMPK is important for maintaining the activity of glycogen phosphorylase and pyruvate kinase, and glycogenolysis/glycolysis in postmortem muscle. Thus, AMPK has an important role in the control of postmortem glycolysis and is crucial for a lower ultimate pH in postmortem muscle. However, the activation of AMPK cannot fully account for the initial rapid glycogenolysis/glycolysis induced by stress and another mechanism must exist for the accelerated glycolysis induced by pre-slaughter stress.

show abstract

“…Recently, it has been shown that the activity of the Na + /K + pump system, which requires significant amounts of ATP for its function, is related to increased lactate levels in both experimental and clinical conditions [23,24], unrelated to the presence of tissue hypoxia. Such enhanced glycolysis can be triggered by cytokine-mediated uptake of glucose [25] or catecholamine-stimulated increased Na-K-pump activity [26,27], supported by both experimental and clinical studies [23,28]. A recent, still unresolved discussion, has focused on the presence of mitochondrial dysfunction in critically ill that could limit pyruvate metabolism (and thus increase lactate levels) in the absence of limited oxygen availability [29,30].…”

Section: Reviewmentioning

confidence: 99%

Clinical use of lactate monitoring in critically ill patients

2013

View full text Add to dashboard Cite

Increased blood lactate levels (hyperlactataemia) are common in critically ill patients. Although frequently used to diagnose inadequate tissue oxygenation, other processes not related to tissue oxygenation may increase lactate levels. Especially in critically ill patients, increased glycolysis may be an important cause of hyperlactataemia. Nevertheless, the presence of increased lactate levels has important implications for the morbidity and mortality of the hyperlactataemic patients. Although the term lactic acidosis is frequently used, a significant relationship between lactate and pH only exists at higher lactate levels. The term lactate associated acidosis is therefore more appropriate. Two recent studies have underscored the importance of monitoring lactate levels and adjust treatment to the change in lactate levels in early resuscitation. As lactate levels can be measured rapidly at the bedside from various sources, structured lactate measurements should be incorporated in resuscitation protocols.

show abstract

Concurrent reduction of glycogenolysis, glycolysis, and NA+/K+ pump activity after hemorrhagic shock

Cited by 10 publications

References 0 publications

α‐ and β‐Glycosyl Sulfonium Ions: Generation and Reactivity

α‐ and β‐Glycosyl Sulfonium Ions: Generation and Reactivity

Role of AMP‐activated protein kinase in the glycolysis of postmortem muscle

Clinical use of lactate monitoring in critically ill patients

Contact Info

Product

Resources

About