Concurrent solitary fibrous tumor and low-grade fibrillary astrocytoma of the cerebellum

Ji, López; Bw, Scheithauer; Giannini, C; Sh, Torp

doi:10.5414/npp29301

Cited by 3 publications

(15 citation statements)

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“…However, the tumor recurred seven times and the patient died 58 months after the initial surgery. Intracranial and/or CNS SFT are usually indolent and only 12 reported cases recurred and/or metastasized 1,2,9–15 . The clinical behavior of extrathoracic SFT is unpredictable based on histological criteria alone 17,18 .…”

Section: Discussionmentioning

confidence: 99%

“…Intracranial and/or CNS SFT usually show benign or indolent clinical behavior, but local recurrence after surgery and even metastasis have been reported in a minority of cases 1,2,9–15 . The histological characteristics of malignant SFT are well described for thoracic SFT: high cellularity; mitotic activity more than 4/10 high power fields (HPF); nuclear pleomorphism; and necrosis 16 .…”

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confidence: 99%

“…Long‐term clinical follow up is recommended for all cases of SFT 17,18 . Of 12 reported cases of intracranial and/or CNS SFT that recurred and/or metastasized, 1,2,9–15 only three had areas with malignant histological features in the initial tumors 2,12,15 . Six cases showed increased proliferative activity in the recurrent tumors that was considered to be progression 9,11–15 …”

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Dedifferentiation and progression of an intracranial solitary fibrous tumor: Autopsy case of a Japanese woman with a history of radiation therapy of the head during infancy

Moritani¹,

Ichihara²,

Hasegawa³

et al. 2010

Pathology International

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Solitary fibrous tumor (SFT) is usually an indolent neoplasm with a low rate of local recurrence and metastasis. Although dedifferentiation of low-grade sarcoma is well documented, the concept of dedifferentiated SFT was not recognized until recently. A case of intracranial SFT with seven recurrences within 5 years, showing progression and dedifferentiation during the course of disease, is reported here. A 51-year-old woman with a history of irradiation during infancy presented with a SFT in the right posterior fossa. Because of the close proximity to the brain stem, the tumor could not be removed completely. The tumor recurred 12, 16, and 28 months after the initial operation. With the repeated recurrences, cellularity, mitotic count, and Ki-67 (MIB-1) index increased gradually. The histology suddenly changed at the fourth recurrence, which occurred 16 months after postoperative radiation therapy for the third recurrence. The tumor revealed a fibrosarcoma-like appearance with necrosis and markedly increased mitotic activity. The tumor further recurred 50, 52, and 55 months after the initial operation with the same fibrosarcoma-like histology. The patient died of uncontrolled tumor 58 months after the initial operation. In this case radiation may have played some role in the tumorigenesis, progression, and dedifferentiation of the SFT.

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Section: Discussionmentioning

confidence: 99%

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Dedifferentiation and progression of an intracranial solitary fibrous tumor: Autopsy case of a Japanese woman with a history of radiation therapy of the head during infancy

Moritani¹,

Ichihara²,

Hasegawa³

et al. 2010

Pathology International

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“…In this case, the mesenchymal tumor area showed spindle cell proliferation of “patternless patterns” with diffuse CD34 expression and high MIB‐1 index up to 30%, that is consistent with an anaplastic solitary fibrous tumor. A biphasic tumor consisting of solitary fibrous tumor and glial tumor is extremely rare, and there is only one reported case in the English literature . The case involved a solitary fibrous tumor associated with WHO grade II diffuse astrocytoma and was found in the cerebellum of a 1‐year‐old boy.…”

Section: Discussionmentioning

confidence: 99%

“…The case involved a solitary fibrous tumor associated with WHO grade II diffuse astrocytoma and was found in the cerebellum of a 1‐year‐old boy. The tumor recurred quickly and showed anaplastic transformation in the solitary fibrous tumor component …”

Section: Discussionmentioning

confidence: 99%

A biphasic tumor consisting of pilocytic astrocytoma with an anaplastic solitary fibrous tumor component in the pineal region: A case report and literature review

et al. 2012

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Here we report a case of a biphasic tumor consisting of pilocytic astrocytoma with anaplastic solitary fibrous tumor component in the pineal region. The majority of the tumor showed typical histologic features of pilocytic astrocytoma. A minor part of the tumor showed marked proliferation of short spindle cells around vessels. These spindle cells showed CD34 and CD99 immunoreactivity. From a review of the literature, we found that only one similar case has been reported. Contrary to the reported case, our case showed anaplastic features of solitary fibrous tumor histology.

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A Comparative Report on Intracranial Tumor-to-Tumor Metastasis and Collision Tumors

et al. 2018

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Concurrent solitary fibrous tumor and low-grade fibrillary astrocytoma of the cerebellum

Cited by 3 publications

References 0 publications

Dedifferentiation and progression of an intracranial solitary fibrous tumor: Autopsy case of a Japanese woman with a history of radiation therapy of the head during infancy

Dedifferentiation and progression of an intracranial solitary fibrous tumor: Autopsy case of a Japanese woman with a history of radiation therapy of the head during infancy

A biphasic tumor consisting of pilocytic astrocytoma with an anaplastic solitary fibrous tumor component in the pineal region: A case report and literature review

A Comparative Report on Intracranial Tumor-to-Tumor Metastasis and Collision Tumors

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