Concussion severity and functional outcome using biomarkers in children and youth involved in organized sports, recreational activities and non-sport related incidents

Papa, Linda; Rosenthal, Kimberly; Cook, Laura; Caire, Michael; Thundiyil, Josef G.; Ladde, Jay; Garfinkel, Alec; Braga, Carolina F.; Tan, Ciara N.; Ameli, Neema J.; López, Marco Antonio; Haeussler, Crystal A; Giordano, Diego Mendez; Giordano, Philip; Ramirez, José; Mittal, Manoj K.; Zonfrillo, Mark R.

doi:10.1080/02699052.2022.2106383

Cited by 6 publications

(2 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…They also appear to maintain statistically significant elevations for anywhere from 3 to 30 days following injury [ 148 , 149 ]. Some studies have suggested that acute concentrations of serum GFAP correlate with injury severity, in addition to cognitive performance and clinical outcomes at multiple time-points following concussion [ 150 , 151 , 152 , 153 ]. GFAP may be more relevant than other biomarkers for cases in which patients delay seeking care due to prolonged clearance from serum [ 148 ].…”

Section: Biochemical Concentrations In Blood and Other Tissuesmentioning

confidence: 99%

“…Several studies have demonstrated that blood levels of UCH-L1 peak very early after head trauma and decrease rapidly, unlike GFAP, which tends to gradually rise over the first 24 h post-injury [ 148 , 153 ]. Day-of-injury measurements of UCH-L1 have demonstrated substantial prognostic value for predicting injury severity, the presence of CT lesions, and the quality of clinical outcomes [ 150 , 153 , 154 , 155 ]. In fact, the U.S. Food and Drug Administration has already approved, for clinical use, a blood test which measures circulating UCH-L1 and GFAP levels, to help determine the need for computed tomography (CT) scans within 12 h of head injury [ 156 ].…”

Section: Biochemical Concentrations In Blood and Other Tissuesmentioning

confidence: 99%

See 1 more Smart Citation

Precision Concussion Management: Approaches to Quantifying Head Injury Severity and Recovery

de Souza,

Jarmol,

Bell

et al. 2023

Brain Sciences

View full text Add to dashboard Cite

Mitigating the substantial public health impact of concussion is a particularly difficult challenge. This is partly because concussion is a highly prevalent condition, and diagnosis is predominantly symptom-based. Much of contemporary concussion management relies on symptom interpretation and accurate reporting by patients. These types of reports may be influenced by a variety of factors for each individual, such as preexisting mental health conditions, headache disorders, and sleep conditions, among other factors. This can all be contributory to non-specific and potentially misleading clinical manifestations in the aftermath of a concussion. This review aimed to conduct an examination of the existing literature on emerging approaches for objectively evaluating potential concussion, as well as to highlight current gaps in understanding where further research is necessary. Objective assessments of visual and ocular motor concussion symptoms, specialized imaging techniques, and tissue-based concentrations of specific biomarkers have all shown promise for specifically characterizing diffuse brain injuries, and will be important to the future of concussion diagnosis and management. The consolidation of these approaches into a comprehensive examination progression will be the next horizon for increased precision in concussion diagnosis and treatment.

show abstract