In this paper, the entropy generation analysis in dropwise condensation in an inclined pipe is carried out. As the vapor passes through the inclined pipe, the flow of the droplets occurs due to the interfacial shear and gravity. Three distinct zones considered in the numerical study include the saturated vapor flowing in the axial direction, saturated liquid traveling through the bottom of the pipe, and the condensate droplet flowing on the inner side of the pipe wall. With the aim of achieving optimal geometrical conditions of the pipe and flow, the entropy generation was calculated for various cases. The results show that the minimum entropy generation of 0.0754 W•K −1 occurs in a configuration with a diameter of 9.5 mm and an inclination angle of 1°. Finally, the Bejan number, irreversibility distribution ratio, and variation according to the flow conditions were presented.