Condensation of Indole with Isatin over AlCl&lt;sub&gt;3&lt;/sub&gt;/Mesoporous Aluminosilicate

Purbaningtias, Tri Esti; Prasetyoko, Didik; Bahruji, Hasliza; Zein, Yusuf Muhammad; Triwahyono, Sugeng; Fadlan, Arif; Qoniah, Imroatul

doi:10.22146/ijc.21224

Cited by 1 publication

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“…In addition to the widely available heterocyclic compounds, they also have significant chemical, biological, and technical applications [3]. Heterocyclics can be found in natural materials, such as vitamins, hormones, antibiotics, and alkaloids, as well as drugs, herbicides, dyes, and other products, such as corrosion inhibitors and stabilizer agents [4][5][6]. One of the heterocyclic compounds with broad bioactivities is isatin and its derivatives [7][8].…”

Section: ■ Introductionmentioning

confidence: 99%

Iodine-catalyzed Synthesis, Antibacterial, and Antioxidant Activity of Isatin Derivatives

Cahyana,

Liandi,

Ongkowidjawa

2024

Indones. J. Chem.

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Isatin is a unique compound with many bioactivities such as antiviral, anti-HIV, antitumor, anti-inflammatory, anticonvulsant, and antifungal. In this study, isatin derivatives were synthesized with an iodine catalyst and tested for antibacterial and antioxidant activities. Isatin derivatives were conducted through a Knoevenagel condensation reaction between isatin and malononitrile. The products were confirmed by thin-layer chromatography, melting point apparatus, FTIR, UV-vis spectroscopy, and LC-MS. The optimum reaction conditions were obtained at 10% mol of catalyst, at boiling point ethanol solvent for 30 min. The yield of the isatin derivative products was 71% (3a), 61% (3b), and 67% (3c). The antibacterial activities of the synthesized compounds were weak activity against S. aureus and E. coli. The antioxidant activity test resulted in IC50 values of 266.47, 220.43, and 654.85 ppm for compounds 3a, 3b, and 3c, respectively. The synthesis method using an iodine catalyst in this reaction offers a higher product yield compared to a catalyst-free reaction.

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