2007
DOI: 10.1371/journal.pone.0000783
|View full text |Cite
|
Sign up to set email alerts
|

Condensin I Reveals New Insights on Mouse Meiotic Chromosome Structure and Dynamics

Abstract: Chromosome shaping and individualization are necessary requisites to warrant the correct segregation of genomes in either mitotic or meiotic cell divisions. These processes are mainly prompted in vertebrates by three multiprotein complexes termed cohesin and condensin I and II. In the present study we have analyzed by immunostaining the appearance and subcellular distribution of condensin I in mouse mitotic and meiotic chromosomes. Our results demonstrate that in either mitotically or meiotically dividing cell… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

2
24
1

Year Published

2008
2008
2019
2019

Publication Types

Select...
9
1

Relationship

1
9

Authors

Journals

citations
Cited by 36 publications
(27 citation statements)
references
References 77 publications
(113 reference statements)
2
24
1
Order By: Relevance
“…The timing of condensin I and II recruitment in mitosis is conserved between worms and mammals (Ono et al, 2004), raising the possibility that it is also conserved in meiosis in all metazoans. Consistent with that, condensin I loads onto chromosomes by prometaphase in mouse spermatocytes (Viera et al, 2007). However, condensin II or NEBD were not analyzed in that study.…”
Section: Discussionsupporting
confidence: 68%
“…The timing of condensin I and II recruitment in mitosis is conserved between worms and mammals (Ono et al, 2004), raising the possibility that it is also conserved in meiosis in all metazoans. Consistent with that, condensin I loads onto chromosomes by prometaphase in mouse spermatocytes (Viera et al, 2007). However, condensin II or NEBD were not analyzed in that study.…”
Section: Discussionsupporting
confidence: 68%
“…Although protein localization studies can only provide tentative conclusions regarding biological relevance, cytological studies of mammalian meiosis, where functional analyses are often technically problematic, have proven to be highly productive in revealing important features of various meiotic events (Page et al, 1998;Moens et al, 2002;Marcon and Moens, 2003;Parra et al, 2004;Viera et al, 2007;Parra et al, 2009). We find that ATRIP localizes to mouse meiotic chromosomes during the leptotene to pachytene stages of meiotic prophase.…”
Section: Evolutionary Conservation Of Ddc2/atrip Meiotic Functionmentioning
confidence: 61%
“…The recently completed surveys of genomic localization of condensin in budding yeast (14,23) show that condensin distribution along the chromosome does not appear to compulsorily adhere to known chromosomal landmarks. At the same time, some correlation with the functional sites of chromosomes is evident in several systems: condensin is enriched at pericentromeric regions (14,34,36,37), condensin is enriched at telomeres under some conditions (23,38) and condensin binding notably coincides with the regions of DNA replication termination in yeast (14). The latter is a good candidate for a universal law determining condensin location and possible loading mechanism in all eukaryotes.…”
Section: Discussionmentioning
confidence: 95%