Condensins are essential for Pseudomonas aeruginosa corneal virulence through their control of lifestyle and virulence programs

Abstract

Pseudomonas aeruginosa is one of the primary causes of bacterial keratitis that often leads to severe eye damage and vision loss (Kaye et al., 2013;Peng et al., 2018;Sy et al., 2012). The high pathogenicity of P. aeruginosa has been attributed to its adaptability to diverse conditions (Skurnik et al., 2013), intrinsically high resistance to antibiotics (Murray et al., 2015), its secretion of numerous virulence factors, and a severe inflammatory response (Gadjeva et al., 2010;Hazlett, 2007;Pearlman et al., 2013). The emergence and spread of multidrug resistance further reduces the efficiency of existing treatments and necessitates the search for new therapeutic targets (Vazirani et al., 2015).Recently, condensins were identified as a novel factor essential for P. aeruginosa pathogenicity (Zhao et al., 2016). Condensins are large multisubunit protein complexes responsible for global chromosome organization (Kleine Borgmann & Graumann, 2014;Nolivos & Sherratt, 2014;Wang & Rudner, 2014). These proteins act as ATP-controlled macromolecular clamps that bring distant DNA segments together, establishing a giant loop chromosome organization

Inhibitor of Chromosome Segregation in Pseudomonas aeruginosa from Fungal Extracts

“…Notably, the expression of MksB but not SMC suppressed the hypersusceptibility of the mutant. The two proteins play nonidentical roles in chromosome segregation. , Therefore, this finding reveals that 4HS affects only some aspects of chromosome dynamics.…”

“…The two proteins play nonidentical roles in chromosome segregation. 14,40 Therefore, this finding reveals that 4HS affects only some aspects of chromosome dynamics.…”