Condition-based maintenance for multi-component systems: Modeling, structural properties, and algorithms

Zhu, Zhicheng; Xiang, Yisha

doi:10.1080/24725854.2020.1741740

Cited by 27 publications

(11 citation statements)

References 68 publications

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“…Zhu and Xiang [2] pointed out that systems in the real world are usually composed of a large number of components with various interactions between them. Wang and Xie [3] believe that networks have been widely used to represent the interaction between individual units in complex systems (such as the Internet of things).…”

Section: Introductionmentioning

confidence: 99%

What Determines the Behavior of a System and How to Design a Satisfactory System for an Expected Behavior

Lin

Cheng

2022

Mobile Information Systems

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Systems are everywhere around us, such as products, production lines, the Internet, companies, schools, hospitals, airports, communities, cities, countries, governments, and military forces. System researchers and engineers always strive to achieve their desired system behaviors. Thus, this paper aims to solve two fundamental problems of systems engineering: what determines the behavior of a system and how to design a satisfactory system for the expected behavior. First, we determine the dimensions of a relationship flow, such as information flow, material flow, and capital flow. Second, we develop new theorems and propositions to solve the first problem. For example, they show that, for a given behavior of a system, if the dominant subsystem of the behavior has the basic level for the behavior, the behavior is only determined by its input flow and relationship flows at or above the basic level, all of which are collectively referred to as total relationship flow (TRF). Third, we develop a relationship flow diagram which is of great significance to system design, just as a circuit diagram to circuit design, and a TRF-oriented system design framework to solve the second problem. In order to show how the framework works, we apply it step by step to the schematic design of an airport system for the required passenger departure procedure service behavior, and get a system example; using this framework to design a system will greatly simplify the complexity of development and improve the maintainability of the system. Therefore, our findings provide a new theory for systems engineering and improve its methods and tools systematically.

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Section: Introductionmentioning

confidence: 99%

What Determines the Behavior of a System and How to Design a Satisfactory System for an Expected Behavior

Lin

Cheng

2022

Mobile Information Systems

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“…While quantitative models supporting FDA inspection decision making has primarily focused on game theoretic models or data driven models, determining the optimal inspection and maintenance time for general maintenance has also been well studied through the lens of condition-based maintenance models (Ahmad & Kamaruddin 2012, Zhu & Xiang 2021. Condition-based maintenance has been popularized for its ability to react to the observed conditions of the system, preventing system failure when degradation is observed sooner than expected.…”

Section: Literature Reviewmentioning

confidence: 99%

Role of Stress Granules in the Pathogenesis of Pulmonary Hypertension Kosmas Kosmas ^1,2, Fotios Spyropoulos^1,2,Helen Christou ^1,2¹Department of Pediatric Newborn Medicine, Brigham and Women’s Hospital, Boston, MA 02115, USA ²Harvard Medical School, Boston, MA 02215, USA

2022

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Background PAH is a devastating and incurable disease characterized by abnormal pulmonary vascular phenotypes and progressive right ventricular failure, but the underlying mechanisms are incompletely understood. There is an urgent need of new therapeutic approaches, and a better understanding of disease pathogenesis is essential in identifying novel pathways that can be therapeutically targeted. Stress granules (SGs) are small intracellular structures that form in response to stress and contain mRNA molecules and mRNA‐binding proteins. These granules allow cells to temporarily halt translation by “parking” or sequestering certain mRNAs in a protected zone (the stress granule) and this allows the cells to survive in conditions of stress. The role of SGs in abnormal vascular and cardiac homeostasis in PAH is not known. Hypotheses We hypothesized that increased SG formation may contribute to both abnormal vascular cellular phenotypes and cardiac failure in human and experimental PAH. Further, we examined whether treatment with the carbonic anhydrase Acetazolamide (ACTZ) which is known to ameliorate experimental PAH, would alter SG tissue abundance in the lungs and heart. Methods We used the adult rat (Sprague Dawley) sugen/hypoxia (Su/Hx) model of severe pulmonary hypertension and studied tissue sections from lungs, heart and skeletal muscle as well as isolated primary pulmonary artery smooth muscle cells (PASMCs). We also used PASMCs from patients with PAH. We applied a combination of immunofluorescence and protein expression studies as well as drug (ACTZ) treatment and in vitro induction of oxidative stress (arsenite) to assess SG formation and SG related markers in experimental PAH and the effect of ACTZ. Results We have discovered that PASMCs from patients with PAH have a higher number of stress granules in response to oxidative stress than cells from normal individuals. We also found that PASMCs from a preclinical model of PAH (Sugen/Hypoxia) have more stress granules and increased SG components in response to oxidative stress compared to normal animals. Further, we found that treatment of PASMCs with ACTZ resulted in lower number of stress granules after cell stress. In addition, we found increased G3BP1 (key component of SG assembly) puncta in alveoli and bronchi and sarcoplasmic G3BP1 puncta in cardiac and soleus muscles from the rat sugen/hypoxia (Su/Hx) model compared to controls and with ACTZ treatment. Conclusions We conclude that there is increased SG formation in PASMCs and tissues in experimental PAH and acetazolamide inhibits stress granule assembly in response to oxidative stress. Further studies are needed to define the role of SG in disease pathogenesis, and evaluate whether targeting stress granules may be effective in restoring normal cellular function and improving PAH.

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“…However, the previous research seldom involves the impact of disassembly operation due to the structural dependence between components on maintenance optimization modeling and failure process [30]. In the framework of multicomponent system maintenance optimization, maintenance strategies can generally be divided into two categories: timebased maintenance (TBM) and condition-based maintenance (CBM) [31]. At present, the existing TBM and CBM modeling research studies mostly focus on single-component systems [32,33].…”

Section: Contributions Ofmentioning

confidence: 99%

Condition‐Based Maintenance Modeling and Reliability Assessment for Multi‐Component Systems with Structural Dependence under Extended Warranty

et al. 2021

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For engineering and production systems, due to the structural dependence between components, the disassembly operation caused by the replacement of components will affect the failure and degradation processes of other components in the system. In order to optimize the extended warranty (EW) cost of the multi‐component system with structural dependence, this paper described the structural dependence and modeled the disassembly operation impact, and then the failure rate model of the component considering the impact of disassembly operation under EW was developed. Combined with the actual situation, a condition-based maintenance (CBM) strategy was employed to construct the EW cost model of the multi‐component system with structural dependence. Monte Carlo simulation was proposed to determine the optimal EW cost of the system and the optimal periodic inspection interval of the CBM strategy. Finally, a numerical example of the planetary gear train of an automobile generator is introduced to demonstrate the feasibility and advantages of the proposed model in EW cost optimization and the analysis of disassembly operation impact on the optimal maintenance strategy.

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Condition-based maintenance for multi-component systems: Modeling, structural properties, and algorithms

Cited by 27 publications

References 68 publications

What Determines the Behavior of a System and How to Design a Satisfactory System for an Expected Behavior

What Determines the Behavior of a System and How to Design a Satisfactory System for an Expected Behavior

Role of Stress Granules in the Pathogenesis of Pulmonary Hypertension Kosmas Kosmas ^1,2, Fotios Spyropoulos^1,2,Helen Christou ^1,2¹Department of Pediatric Newborn Medicine, Brigham and Women’s Hospital, Boston, MA 02115, USA ²Harvard Medical School, Boston, MA 02215, USA

Condition‐Based Maintenance Modeling and Reliability Assessment for Multi‐Component Systems with Structural Dependence under Extended Warranty

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Condition-based maintenance for multi-component systems: Modeling, structural properties, and algorithms

Cited by 27 publications

References 68 publications

What Determines the Behavior of a System and How to Design a Satisfactory System for an Expected Behavior

What Determines the Behavior of a System and How to Design a Satisfactory System for an Expected Behavior

Role of Stress Granules in the Pathogenesis of Pulmonary Hypertension Kosmas Kosmas 1,2, Fotios Spyropoulos1,2,Helen Christou 1,21Department of Pediatric Newborn Medicine, Brigham and Women’s Hospital, Boston, MA 02115, USA 2Harvard Medical School, Boston, MA 02215, USA

Condition‐Based Maintenance Modeling and Reliability Assessment for Multi‐Component Systems with Structural Dependence under Extended Warranty

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Role of Stress Granules in the Pathogenesis of Pulmonary Hypertension Kosmas Kosmas ^1,2, Fotios Spyropoulos^1,2,Helen Christou ^1,2¹Department of Pediatric Newborn Medicine, Brigham and Women’s Hospital, Boston, MA 02115, USA ²Harvard Medical School, Boston, MA 02215, USA