Abstract. We explore the validity of the circular law for random matrices with non i.i.d. entries. Let A be a random n × n real matrix having as a random vector in R n×n a log-concave isotropic unconditional law. In particular, the entries are uncorellated and have a symmetric law of zero mean and unit variance. This allows for some dependence and non equidistribution among the entries, while keeping the special case of i.i.d. standard Gaussian entries. Our main result states that as n goes to infinity, the empirical spectral distribution of 1 √ n A tends to the uniform law on the unit disc of the complex plane.