Conditional pharmacology: II. Ambivalent effects of aurocyanide, a putative active metabolite of anti-arthritic gold drugs, on human and rat PMN leucocytes

Gadd, Stephen; Whitehouse, M. W.; Vernon‐Roberts, B.

doi:10.1007/bf02755881

Cited by 5 publications

(2 citation statements)

References 12 publications

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“…An earlier study found that a single non-toxic dose of NaAu(CN) 2 at 10 mg/rat completely ablated arthritis development when co-administered intra-lymphatically with the adjuvant. By contrast much higher and quite toxic doses of aurothiolates (>25 mg/rat) were needed to suppress arthritis development (Gadd et al, 1992). c) NaAu(CN) 2 was also tested for its effect upon the rapid development of the oedema induced by an intrapedal injection of sodium carrageenan.…”

Section: • In Vivomentioning

confidence: 99%

Aurocyanide, dicyano-aurate (I), a pharmacologically active metabolite of medicinal gold complexes

2008

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The aurocyanide anion, Au(CN) (2) (-) , is a human metabolite of several anti-rheumatic gold complexes containing monovalent gold (I) bound to a sulphur ligand. This article reviews some of the chemical and pharmacological properties of this intriguing metabolite, and reports its anti-arthritic and anti-inflammatory activity in rats. Au(CN) (2) (-) is generated from the therapeutic gold complexes by small amounts of hydrogen cyanide, HCN, produced from thiocyanate, SCN(-), by myeloperoxidase (MPO) an enzyme in neutrophils which normally produces hypochlorite, OCl(-). Thus, Au(CN) (2) (-) is formed at sites of inflammation where activated neutrophils are present. This includes atherosclerotic lesions as well as inflamed joints. MPO also oxidises Au(CN) (2) (-) to Au(III) complexes such as Au(CN) (4) (-) .Au(CN) (2) (-) is normally a very stable monovalent gold complex. In a biological context, only low concentrations are ever present at both extracellular and intracellular sites. However, Au(CN) (2) (-) produced locally may facilitate the cellular uptake and hence the therapeutic and toxic effects of gold drugs. Au(CN) (2) (-) may also be involved in a redox cycle where Au(CN) (2) (-) is oxidised to Au(CN) (4) (-) which is, in turn, reduced back to Au(CN) (2) (-) by endogenous thiols. There are still many questions to be resolved concerning Au(CN) (2) (-) including its intrinsic toxicity and the extent to which it may contribute to the overall anti-arthritic activities of the gold-thiolates from which it is formed in vivo.

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Section: • In Vivomentioning

confidence: 99%

Aurocyanide, dicyano-aurate (I), a pharmacologically active metabolite of medicinal gold complexes

2008

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“…In Rattenneutrophilen (normal und arthritisch) verstärkte Gold(I)cyanid jedoch die Peroxidbildung. Bei beiden Zelltypen verringerte sich gleichzeitig die mittlere Zelldichte (Gadd et al 1992). …”

Section: In Vitrounclassified

Gold und seine anorganischen Verbindungen [MAK Value Documentation in German language, 2006]

2012

The MAK‐Collection for Occupational Health and Safety

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Veröffentlicht in der Reihe Gesundheitsschädliche Arbeitsstoffe , 41. Lieferung, Ausgabe 2006 Der Artikel enthält folgende Kapitel: Allgemeiner Wirkungscharakter Wirkungsmechanismus Toxikokinetik und Metabolismus Aufnahme, Verteilung, Ausscheidung Metabolismus Erfahrungen beim Menschen Einmalige Exposition Wiederholte Exposition Wirkung auf Haut und Schleimhäute Allergene Wirkung Reproduktionstoxizität Genotoxizität Kanzerogenität Tierexperimentelle Befunde und In‐vitro‐Untersuchungen Akute Toxizität Subakute, subchronische und chronische Toxizität Wirkung auf Haut und Schleimhäute Allergene Wirkung Reproduktionstoxizität Genotoxizität Kanzerogenität Sonstige Wirkungen Bewertung

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Effects of prostaglandin E1 analogue, misoprostol, on the development of adjuvant arthritis in rats

Rainsford

Whitehouse

Vernon‐Roberts

1995

Inflammopharmacology

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Conditional pharmacology: II. Ambivalent effects of aurocyanide, a putative active metabolite of anti-arthritic gold drugs, on human and rat PMN leucocytes

Cited by 5 publications

References 12 publications

Aurocyanide, dicyano-aurate (I), a pharmacologically active metabolite of medicinal gold complexes

Aurocyanide, dicyano-aurate (I), a pharmacologically active metabolite of medicinal gold complexes

Gold und seine anorganischen Verbindungen [MAK Value Documentation in German language, 2006]

Effects of prostaglandin E1 analogue, misoprostol, on the development of adjuvant arthritis in rats

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