Individual electrodynamically trapped and laser cooled ions are addressed in frequency space using radio-frequency radiation in the presence of a static magnetic field gradient. In addition, an interaction between motional and spin states induced by an rf field is demonstrated employing rfoptical double resonance spectroscopy. These are two essential experimental steps towards realizing a novel concept for implementing quantum simulations and quantum computing with trapped ions.PACS numbers: 37.10. Vz, 37.10.Ty, 32.60.+i Quantum simulations addressing a specific scientific problem and universal quantum computation are expected to yield new insight into as of yet unsolved physical problems that withstand efficient treatment on a classical computer (e.g., [1]). Already a small number of qubits (i.e., a few tens) used for quantum simulations could solve problems even beyond the realm of quantum information science. Creating and investigating entanglement in large physical systems is a related important experimental challenge with implications for our understanding of the transition between the elusive quantum regime and the classical world [2].Laser cooled atomic ions confined in an electrodynamic cage have successfully been used for quantum information processing (QIP) [3] and advantages and difficulties associated with this system have been and still are subject to detailed investigations. The electromagnetic radiation used to coherently drive ionic resonances that serve as qubits needs to be stable against variations in frequency, phase, and amplitude over the course of a quantum computation or simulation. Experimentally this is particularly challenging when laser light is used for realizing quantum gates. When employing laser light additional issues need to be dealt with to allow for accurate qubit manipulation such as the intensity profile of the laser beam, its pointing stability, and diffraction effects. Furthermore, the motional state of the ion chain strongly affects the gate fidelity which requires ground state cooling and low heating rates during the gate operation [4]. Also, spontaneous scattering of laser light off excited electronic states may pose a limit for the coherence time of a quantum many-body state. The probability for scattering can be reduced by increasing the detuning from excited states (when two laser light fields are used that drive a Raman transition between hyperfine or Zeeman states) which, however, leads to an increasing demand for laser power [5].For generating Raman laser beams with a desired frequency difference, first a radio-frequency (rf) or microwave signal at this difference frequency has to be generated that is then "imprinted" on the laser light and send to the ions. Using rf or microwave radiation directly for coherent driving of qubit transitions is impeded in usual ion trap schemes, since, (i) individual addressing of qubits by focusing radiation on just one ion is difficult due to the long wavelength of rf radiation, and (ii) the required coupling between qubit stat...