The article reviews the most important results in the field of numerical mathematics obtained by Professor V. V. Strygin’s disciples and the disciples of his disciples in 2000–2019 in the city of Samara. We present the results on spline interpolation of functions with a boundary layer, methods and algorithms for a posteriori adaptation of computational grids for singularly perturbed boundary value problems and the results on applied wavelet analysis based on spline wavelets.