Conditioned locomotion induced by unilateral intrastriatal administration of Apomorphine: D2 receptor activation is critical but not the expression of the unconditioned response

Double Dissociation of the Effects of Haloperidol and the Dopamine D3 Receptor Antagonist ABT-127 on Acquisition vs. Expression of Cocaine-Conditioned Activity in Rats

“…The finding that haloperidol, given during cocaine conditioning, blocked the acquisition of conditioned activity agrees with other reports using D2-preferring receptor antagonists Hahn, 1983, Beninger andHerz, 1986;Fontana et al, 1993;Dias et al, 2006). Reimer and MartinIverson (1994) did not observe a block of acquisition of conditioned activity with haloperidol but they used one dose, and their purpose was explicitly to use a subthreshold dose of haloperidol that could be tested for synergistic effects with the calcium channel blocker nimodipine.…”

“…Treatment with the D2-preferring receptor antagonists pimozide (Beninger and Hahn, 1983;Beninger and Herz, 1986), haloperidol [4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidyl]-1-(4-fluorophenyl)-butan-1-one], raclopride, or sulpiride (Fontana et al, 1993;Dias et al, 2006 but see Cervo and Samanin, 1996), but not metoclopramide (Mazurski and Beninger, 1991), given during the conditioning phase, prevented the acquisition of conditioned activity. However, during the expression test, pimozide (Beninger and Hahn, 1983;Beninger and Herz, 1986) and raclopride (Fontana et al, 1993 but see Cervo and Samanin, 1996) failed to block the expression of conditioned activity.…”

Apomorphine-induced context-specific behavioural sensitization is prevented by the D1 antagonist SCH-23390 but potentiated and uncoupled from contextual cues by the D2 antagonist sulpiride

“…The animals were divided into the following groups: vehicle (n=6), SUL-10 + APO-unpaired (n=6), SUL-10 + APO-paired (n=6), SUL-100 + APOunpaired (n=6) and SUL-100 + APO-paired (n=6). For the SCH-23390 experiment, the low and high doses of 0.01 and 0.05 mg/kg SCH-23390 were derived from previous reports of efficacy in the selected dose range (Ushijima et al 1995;Dias et al 2006). The animals were divided into the following groups: vehicle (n=6), SCH-0.01+APO-unpaired (n=6), SCH-0.01+APO-paired (n=6), SCH-0.05 + APO-unpaired (n=6) and SCH-0.05 + APO-paired (n=6).…”

Exacerbated mechanical allodynia in rats with depression-like behavior

“…Open field test was used to examine exploratory and locomotor activities (Wesierska et al, 2006;Pertsov, 2006;Bellermann et al, 2006;Dias et al, 2006). This test was performed under room lights in an open box (57 × 57 cm with a 43 cm tall wall) marked with peripheral and internal squares (Bellermann et al, 2006;Dias et al, 2006;Pertsov, 2006).…”

“…This test was performed under room lights in an open box (57 × 57 cm with a 43 cm tall wall) marked with peripheral and internal squares (Bellermann et al, 2006;Dias et al, 2006;Pertsov, 2006). During a 5-min session, the rat's locomotor activity was recorded as the number of crossings into peripheral and internal squares, whereas exploratory activities were assessed as the episodes of rearing against the field wall.…”