Conditioned taste aversion and traditional learning

Klosterhalfen, Sibylle; Klosterhalfen, Wolfgang

doi:10.1007/bf00309122

Cited by 76 publications

(21 citation statements)

References 280 publications

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“…Although the present studies appear to qualify the conclusion of Klosterhalfen and Klosterhalfen (1985) regarding the long-lived nature of taste memory , it may be possible both to account for the present data and to assume that taste memory is relatively long lived . In order to do so , however, it is necessary to make a different assumption about the processing of stimu lus events than is typically made regarding taste stimuli.…”

Section: Discussionsupporting

confidence: 44%

“…Robust taste aversions have been conditioned with extended delays between taste presentation and toxicosis (e.g., 9-12 h, see Nachman, 1970;Revusky , 1968;Smith & Roll, 1967; see Etscorn & Stephens, 1973, for a report of conditioned aversion with a delay of 24 h between between taste exposure and subsequent toxicosis). In a review of taste aversion learning, Klosterhalfen and Klosterhalfen (1985) advanced the position that the ability of animals to form associations over long delays within the CT A procedure is a function of the specific conditioned stimulus used in taste aversion research, that is, taste . In particular, they noted that taste may have unique properties, one of these being that memory of it is longer lived than is memory of other stimulus modalities (see also Lett, 1979).…”

mentioning

confidence: 99%

“…The purpose of Experiment 1 was to ascertain whether long delays could be supported within a modified discrimination procedure, allowing for a determination of whether taste memory is long lived in nature (see Klosterhalfen & Klosterhalfen, 1985) or whether long-delay learning is unique to the taste aversion design.…”

mentioning

confidence: 99%

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Memory for tastes in an operant delayed discrimination

Bitler

Riley

1992

Bull. Psychon. Soc.

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Section: Discussionsupporting

confidence: 44%

mentioning

confidence: 99%

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Memory for tastes in an operant delayed discrimination

Bitler

Riley

1992

Bull. Psychon. Soc.

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“…Additionally, given that both the aversive and rewarding effects likely contribute to drug taking, it will also be necessary to determine which factors may influence the strength of each of these and, thus, their overall balance. For example, age has already been shown to influence MDPV-induced aversions (Merluzzi et al, 2014), but a number of other experiential and subject factors such as sex, strain, dose and drug history should also be examined given their impact on the aversive and rewarding effects of other drugs of abuse (Freeman and Riley, 2009; Klosterhalfen and Klosterhalfen, 1985; Tzschentke, 1998). Determining how the balance between aversion and reward influences MDPV-induced self-administration, and the factors that can alter this balance, may provide valuable insight into possible risk factors for use and overall abuse potential.…”

Section: Discussionmentioning

confidence: 99%

An assessment of MDPV-induced place preference in adult Sprague-Dawley rats

King

Wetzell

Rice

et al. 2015

Drug and Alcohol Dependence

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OBJECTIVE Most drugs of abuse have both aversive and rewarding effects, and the use and abuse potential of such drugs is thought to be a function of a balance of these affective properties. Characterizing these effects and their relative balance may provide insight into abuse vulnerability. One drug that has received recent attention is methylenedioxyparavalerone (MDPV), a monoamine transport inhibitor similar to, but significantly more potent than, cocaine. MDPV is self-administered and has been shown to produce aversive and rewarding effects in adult rats. The present study extended this characterization of the affective properties of MDPV by examining its ability to support place conditioning at a range of doses known to produce taste avoidance. METHODS Male Sprague-Dawley rats were injected with MDPV (1, 1.8 or 3.2 mg/kg) or saline and placed on the non-preferred side of a place conditioning apparatus for 30 min. On the next day, they were given an injection of saline and placed on the preferred side. This was repeated three times for a total of four conditioning cycles, and side preference was assessed on a final test. RESULTS All doses of MDPV produced significant increases in time spent in the drug-paired chamber, an effect not seen in vehicle-treated animals. CONCLUSIONS That the same doses of MDPV induced both taste avoidance and place preference allows assessments of how other factors might impact these effects and how they may, in turn, contribute to its abuse liability.

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“…First, the paradigm employed here was taste aversion rather than conditioned suppression of ongoing behaviour. So far, we have regarded taste aversion learning as Pavlovian conditioning (see Klosterhalfen & Klosterhalfen, 1985), but Garcia (1989) argued that it is a different learning process. Accordingly, underlying mechanisms of overshadowing and latent inhibition might differ between taste aversion learning and other conventional Pavlovian preparations, such as conditioned suppression (but see Shnur, 1971).…”

Section: Dmentioning

confidence: 99%