Conditioning lesions of peripheral nerves change regenerated axon numbers

Jenq, Chung Bii; Jenq, Lee Lan; Bear, Howard M.; Coggeshall, Richard E.

doi:10.1016/0006-8993(88)90057-1

Cited by 36 publications

(20 citation statements)

References 23 publications

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“…Regenerating nonmyelinated axons are known have been documented to branch far less than myelinated axons. 16 The doubling of CE+ axons most likely represents branching of regenerating alpha motor axons, which are known to elaborate 3-5 branches. 10,16,22,34,38 The peak in axon numbers distal to nerve transection is reportedly highest around 90 days, decreasing to normal levels by around 24 months in suture-repaired rat sciatic nerves.…”

Section: Discussionmentioning

confidence: 99%

Myelinated sensory and alpha motor axon regeneration in peripheral nerve neuromas

et al. 1998

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Section: Discussionmentioning

confidence: 99%

Myelinated sensory and alpha motor axon regeneration in peripheral nerve neuromas

et al. 1998

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“…Peripheral axonal injury induces in motor and sensory nerve cell bodies poorly understood responses that support axonal growth (McQuarrie et al, 1977;Jackson and Diamond, 1984;Havton and Kellerth 1987;Richardson and Verge, 1987;Jenq et al, 1988). With rare exceptions (Rich and Johnson, 1985;Kanje et al, 1989), perikaryal reactions associated with regeneration have been observed only after axonal lesions that reduce retrograde transport of trophic molecules from Schwann cells and/or target tissues (Richardson and Verge, 1986;Bisby, 1988;Woolf et al, 1990).…”

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confidence: 99%

Inflammation near the nerve cell body enhances axonal regeneration

1991

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Although crushed axons in a dorsal spinal root normally regenerate more slowly than peripheral axons, their regeneration can be accelerated by a conditioning lesion to the corresponding peripheral nerve. These and other observations indicate that injury to peripheral sensory axons triggers changes in their nerve cell bodies that contribute to axonal regeneration. To investigate mechanisms of activating nerve cell bodies, an inflammatory reaction was provoked in rat dorsal root ganglia (DRG) through injection of Corynebacterium parvum. This inflammation enhanced regeneration in the associated dorsal root, increasing 4-fold the number of regenerating fibers 17 d after crushing; peripheral nerve regeneration was not accelerated. A milder stimulation of dorsal root regeneration was detected after direct injection of isogenous macrophages into the ganglion. It is concluded that changes favorable to axonal regeneration can be induced by products of inflammatory cells acting in the vicinity of the nerve cell body. Satellite glial cells and other unidentified cells in lumbar DRG were shown by thymidine radioautography to proliferate after sciatic nerve transection or injection of C. parvum into the ganglia. Intrathecal infusion of mitomycin C suppressed axotomy-induced mitosis of satellite glial cells but did not impede axonal regeneration in the dorsal root or the peripheral nerve. Nevertheless, the similarity in reactions of satellite glial cells during 2 processes that activate neurons adds indirect support to the idea that non-neuronal cells in the DRG might influence regenerative responses of primary sensory neurons.

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“…Previous studies have shown that myelinated axons after triple nerve crush were much more increased than those after single nerve crush and nerve crush might be useful in conditions where it would be desirable to increase numbers of processes from surviving neurons, although they did not mentioned the association with the motor function (Jenq and Coggeshall, 1987;Jenq et al, 1988). In this study, we investigated the effect of repeated nerve crush on the motor function.…”

Section: Discussionmentioning

confidence: 97%

“…There are only a few reports about repeated crush injuries of peripheral nerve (Jenq and Coggeshall, 1987;Jenq et al, 1988), and no reports about functional assessment for repeated nerve crush. In the present study, we evaluated the repeated crush injuries of sciatic nerve compared to the single nerve crush.…”

Section: Discussionmentioning

confidence: 99%

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Effects of repeated crush injuries on motor functional recovery of the sciatic nerve

Itsubo

Fukushima

Kakegawa

et al. 2012

Neurological Research

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The effects of repeated crush injuries of peripheral nerve remains in poorly understood. In this study, the rats were divided on five groups (control, single crush, double crush on once a week, triple crush on once a week, triple crush on every four weeks) and analyzed to investigate the influence on motor function by repeated nerve crush injuries. Additionally, the muscle fiber diameter and reinnervation of the tibialis anterior muscle were measured and comparisons were made with two groups, single crush group and triple crush group. The five groups had their respective pattern of dysfunction and restoration. The motor function in four groups except the group of triple crush on once a week eventually recovered to normal range. The group of triple crush on once a week was not obtained the full restoration of the motor function. The motor function of double and triple crush groups on once a week were significantly low in comparison with control group and it took longer to obtain the full restoration.In analysis of the muscle, the width of muscle fiber in single crush group was clearly wider and the muscle fiber reinnervation in single crush group was significantly faster than in triple crush group.In the rats with repeated sciatic nerve crush injuries at short intervals before recovering motor function, the function could not recover completely because of delay of the reinnervation and the atrophy of the muscles.

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Conditioning lesions of peripheral nerves change regenerated axon numbers

Cited by 36 publications

References 23 publications

Myelinated sensory and alpha motor axon regeneration in peripheral nerve neuromas

Myelinated sensory and alpha motor axon regeneration in peripheral nerve neuromas

Inflammation near the nerve cell body enhances axonal regeneration

Effects of repeated crush injuries on motor functional recovery of the sciatic nerve

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