Conditions Associated with Nonimmune Hydrops Fetalis

Hydrops fetalis – has there been a change in diagnostic spectrum and mortality?

“…Metabolic causes should be considered, including lysosomal storage disease, which is found in 1-2% of all NIH cases [24][25][26][27][28][29][30][31]. The diagnosis can often be confirmed by assessing cultured cells (skin fibroblasts, amniotic fluid cells, or chorionic villus tissue) for specific metabolic parameters.…”

Hydrops fetalis: manifestation in lysosomal storage diseases including Farber disease

“…Nonimmune hydrops fetalis (NIH) has many causes [19,26] and it is interesting that inborn errors of metabolism, including lysosomal storage diseases, are present in 1%-2% of all NIH cases [19,26,44]. We here report on the first case of disseminated lipogranulomatosis (Farber disease) presenting with hydrops fetalis.…”

Coagulation and fibrinolysis in viable mid-trimester pregnancies of normal, intrauterine growth retardation, chromosomal anomalies and hydrops fetalis and their eventual obstetric outcome

“…Hematologic disorders are seen in approximately 10 % to 27 % of the cases of nonimmune hydrops fetalis [5,15,28,33] and anemia leading to heart failure, edema, ascites and anasarca, the final common finding [1]. Hydrops fetalis is a non-specific pathological state resulting from etiological factors affecting the feto-placental unit and its causes can be broadly divided into either immune or non-immune.…”