The granites of the Ukrainian crystalline shield and the Donetsk-Dnieper hollow of the Pre-Cambrian basement, discovered at a depth of 840…900 to 3420 m were irradiated on a KUT-1 linear electron accelerator with the following parameters: electron energy Е ≈ 7 MeV, average beam current I = 500 µA, temperature of the irradiated samples Т~ 40°С, absorbed dose Dabs = 107 Gy. Gamma-activation analysis was used to determine the content of elements in the samples. The samples were irradiated by bremsstrahlung from the linear accelerator electron NSC KIPT with energy 23 MeV and current 500 µA. The structure and phase composition of samples were investigation by infrared spectroscopy in the frequency 400…4000 cm-1. Crystal optical studies were carried out on polarizing microscope using immersion liquides. It is shown that high-energy electron irradiation of granites causes radiationstimulated transformations in the structure and phase homogeneity of mineral. The most pronounced changes in biotites after high-energy electron irradiation of granites are manifested in a change in the color of biotite, apparently due to oxide phases Fe2O3 and Fe3O4. Considering the state of granites under radiation conditions it can be used for the immobilization and disposal of radioactive waste.