Conducting Polymer-Infused Electrospun Fibre Mat Modified by POEGMA Brushes as Antifouling Biointerface

Ashraf, Jesna; Lau, Sandy; Akbarinejad, Alireza; Evans, Clive W.; Williams, David E.; Barker, David; Travaš-Sejdić, Jadranka

doi:10.3390/bios12121143

Cited by 5 publications

(3 citation statements)

References 55 publications

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“…Wang et al grafted soft poly(ethylene glycol)methyl ether methacrylate (PEGMMA) side chains with a small amount of photo-cross-linkable glycidyl methacrylate (GMA) side chains onto a conductive poly(3-hexylthiophene) (P3HT) backbone and demonstrated photopatternable and stretchable CP electrodes (Figure C–E) . Ashraf et al grafted poly(oligo (ethylene glycol) methyl ether methacrylate) (POEGMA) brushes to PEDOT to afford antifouling properties …”

Section: Methodsmentioning

confidence: 99%

“…154 Baek et al grafted soft poly(acrylate urethane) (PAU) side chains to poly(3-hexylthiophene) (P3HT) backbones via atom transfer radical polymerization (ATRP), which provided self-healing and stretchability to the P3HT due to the hydrogen bonding introduced by PAU. 155 158 In addition, certain functional side chains could be particularly useful for specific biosensing applications, such as aptamer/antibody anchoring handles for selective DNA or protein recognition and sensing. 159 As an example, Peng et al synthesized pyrrole derivatives with unsaturated acrylic acid side chains and utilized them for DNA sensing.…”

Section: Organic Bioelectronic Materialsmentioning

confidence: 99%

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Electrochemical and Electrical Biosensors for Wearable and Implantable Electronics Based on Conducting Polymers and Carbon-Based Materials

Zhang,

Zhu,

et al. 2023

Chem. Rev.

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Bioelectronic devices are designed to translate biological information into electrical signals and vice versa, thereby bridging the gap between the living biological world and electronic systems. Among different types of bioelectronics devices, wearable and implantable biosensors are particularly important as they offer access to the physiological and biochemical activities of tissues and organs, which is significant in diagnosing and researching various medical conditions. Organic conducting and semiconducting materials, including conducting polymers (CPs) and graphene and carbon nanotubes (CNTs), are some of the most promising candidates for wearable and implantable biosensors. Their unique electrical, electrochemical, and mechanical properties bring new possibilities to bioelectronics that could not be realized by utilizing metals-or silicon-based analogues. The use of organic-and carbon-based conductors in the development of wearable and implantable biosensors has emerged as a rapidly growing research field, with remarkable progress being made in recent years. The use of such materials addresses the issue of mismatched properties between biological tissues and electronic devices, as well as the improvement in the accuracy and fidelity of the transferred information. In this review, we highlight the most recent advances in this field and provide insights into organic and carbon-based (semi)conducting materials' properties and relate these to their applications in wearable/implantable biosensors. We also provide a perspective on the promising potential and exciting future developments of wearable/implantable biosensors.

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Section: Methodsmentioning

confidence: 99%

Section: Organic Bioelectronic Materialsmentioning

confidence: 99%

Electrochemical and Electrical Biosensors for Wearable and Implantable Electronics Based on Conducting Polymers and Carbon-Based Materials

Zhang,

Zhu,

et al. 2023

Chem. Rev.

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“…For examples, Ashraf et al electropolymerized a P(EDOT-co-EDOTBr) coating on an electrospun fiber mat and then used the Br residues in the EDOTBr comonomer as an initiator for SI-ATRP grafting of POEGMA brushes, resulting in significantly improved anti-fouling properties relative to surfaces with no POEGMA brush coating. [106] Another ATRP-related polymerization, surface initiated-activator generated by electron transfer (SI-AGET) ATRP, has been used in a similar manner but offers the advantage of using non-radical forming reducing agents such as ascorbic acid or tin 2-ethylhexanoate, avoiding the for-mation of byproducts that might create new initiated chains in solution while also reducing dissolved oxygen to allow polymerization to proceed in the presence of air. [107,108] Hackett et al used this approach to graft anti-fouling (poly(ethylene glycol) methyl ether methacrylate (PEGMMA)-co-(diethylene glycol) methyl ether methacrylate (DEGMMA)) brushes from a similar P(EDOT-co-EDOTBr) coating electropolymerized on a gold electrode.…”

Section: Electropolymerizationmentioning

confidence: 99%

Anti‐Fouling Polymer or Peptide‐Modified Electrochemical Biosensors for Improved Biosensing in Complex Media

Saxena,

Sen,

Soleymani

et al. 2024

Advanced Sensor Research

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Electrochemical biosensing represents a highly effective technology for detecting disease biomarkers given its high sensitivity, low and clinically relevant limit of detection, and cost effectiveness. However, in complex media such as urine, blood, sweat or saliva, biosensing performance can be significantly impacted by electrode biofouling by proteins, cells, lipids, and other matrix components. Such biofouling leads to reduced signal from the target analyte coupled with an elevated background signal, resulting in poor signal‐to‐noise ratios (SNRs), reduced sensitivity, and lower specificity. This comprehensive review describes the design of anti‐fouling polymers and peptides as a potential solution to prevent or suppress electrochemical biosensor fouling. Various anti‐fouling polymers and peptides developed for improved biosensing in complex media are summarized in the context of their mechanism(s) of anti‐fouling, methods of deposition, and practical applications. Recent advances and persistent challenges in the field are also reviewed to provide perspectives on new directions toward enhancing anti‐fouling in electrochemical biosensors.

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Grafting of Porous Conductive Fiber Mats with an Antifouling Polymer Brush by Means of Filtration‐Based Surface Initiated ATRP

Schon

Travaš-Sejdić

2023

Macromol. Rapid Commun.

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This work addresses the challenge of surface modification of porous, electrospun fiber mats containing an insoluble conducting polymer coating. Herein, a novel methodology of grafting a polymer brush onto conducting polymer fiber mats is developed that employs filtering of the polymerization solution through the fiber mat. An electrospun sulfonated polystyrene‐poly(ethylene‐ran‐butylene)‐polystyrene (sSEBS) fiber mat is first coated with a layer of conducting copolymer bearing an Atom Transfer Radical Polymerization (ATRP) initiating functionality (PEDOT‐Br). The surface‐initiated ATRP from the fibers’ surface is then carried out to graft a hydrophilic polymer brush (poly(ethylene glycol) methyl ether methacrylate) by means of filtering the polymerization solution through the fiber mat. Scanning electron microscopy (SEM) images reveal a progressive change in the morphology of the fiber mat surface with the increasing volume of the filtrated polymerization solution, while energy dispersive X‐ray spectrosdcopy (EDX) spectra show a change in the atomic oxygen to sulfur (O/S) ratio, therefore confirming the successful grafting from the fibers’ surface. The conductive fiber mat grafted with hydrophilic brushes shows a 20% reduction in the non‐specific adsorption of bovine serum albumin (BSA) compared to a pristine fiber mat. This study is a proof‐of‐concept for this novel, filtration‐based, surface‐initiated polymerization methodology.

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Conducting Polymer-Infused Electrospun Fibre Mat Modified by POEGMA Brushes as Antifouling Biointerface

Cited by 5 publications

References 55 publications

Electrochemical and Electrical Biosensors for Wearable and Implantable Electronics Based on Conducting Polymers and Carbon-Based Materials

Electrochemical and Electrical Biosensors for Wearable and Implantable Electronics Based on Conducting Polymers and Carbon-Based Materials

Anti‐Fouling Polymer or Peptide‐Modified Electrochemical Biosensors for Improved Biosensing in Complex Media

Grafting of Porous Conductive Fiber Mats with an Antifouling Polymer Brush by Means of Filtration‐Based Surface Initiated ATRP

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