Conducting polymers, dual neurotrophins and pulsed electrical stimulation — Dramatic effects on neurite outgrowth

Thompson, Brianna C.; Richardson, Rachael T.; Moulton, Simon E.; Evans, A. M.; O’Leary, Stephen; Clark, Graeme M.; Wallace, Gordon G.

doi:10.1016/j.jconrel.2009.09.016

Cited by 216 publications

(118 citation statements)

References 26 publications

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“…Their findings indicated that the electrical stimulation enhanced the rate of neurite extension on both random and aligned nanofibres. Thompson et al(2010) also showed that neurite outgrowth from cochlear neural explants grown on the PPy-containing NT-3 and BDNF was significantly improved when the polymer containing both neurotrophins was electrically stimulated. Electrical stimulation of protein-loaded PPy has a dramatic effect on auditory nerve survival and growth from cochlear neural explants.…”

Section: Application Of Electrical Stimulation In Nerve Tissue Enginementioning

confidence: 90%

“…An in vitro study using nerve cells showed that the incorporation of NGF can modify the biological interactions of the conductive polymers. However, direct covalent attachment of moieties to the backbone of a conducting polymer usually has an adverse effect on the electrical properties of the polymer (Thompson et al, 2010). Lee et al (2009a) developed copolymers of Nhydroxyl succinimidyl ester pyrrole (PPy-NSE) and further modified it, using immobilization of NGF molecules on PPy-NSE films.…”

Section: Modification Of Conductive Polymers With Bioactive Moleculesmentioning

confidence: 99%

“…Such novel scaffolds, providing electroconductive and neurotrophic activities, has potential for neural applications, such as tissue engineering and biosensor applications. Thompson et al (2010) incorporated neurotrophin-3 (NT-3) and brainderived neurotrophic factor (BDNF) into PPy during electrosynthesis and evaluated neurite outgrowth from cochlear neural explants grown on PPy containing NT-3 and BDNF. Neurite outgrowth from explants grown on polymers containing both NT-3 and BDNF showed significant improvement over PPy doped specifically with NT-3, due to the synergistic effect of the two neurotrophins.…”

Section: Modification Of Conductive Polymers With Bioactive Moleculesmentioning

confidence: 99%

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Application of conductive polymers, scaffolds and electrical stimulation for nerve tissue engineering

Ghasemi‐Mobarakeh¹,

Prabhakaran²,

Morshed³

et al. 2011

J Tissue Eng Regen Med

613

389

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Among the numerous attempts to integrate tissue engineering concepts into strategies to repair nearly all parts of the body, neuronal repair stands out. This is partially due to the complexity of the nervous anatomical system, its functioning and the inefficiency of conventional repair approaches, which are based on single components of either biomaterials or cells alone. Electrical stimulation has been shown to enhance the nerve regeneration process and this consequently makes the use of electrically conductive polymers very attractive for the construction of scaffolds for nerve tissue engineering. In this review, by taking into consideration the electrical properties of nerve cells and the effect of electrical stimulation on nerve cells, we discuss the most commonly utilized conductive polymers, polypyrrole (PPy) and polyaniline (PANI), along with their design and modifications, thus making them suitable scaffolds for nerve tissue engineering. Other electrospun, composite, conductive scaffolds, such as PANI/gelatin and PPy/poly(ε-caprolactone), with or without electrical stimulation, are also discussed. Different procedures of electrical stimulation which have been used in tissue engineering, with examples on their specific applications in tissue engineering, are also discussed.

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Section: Application Of Electrical Stimulation In Nerve Tissue Enginementioning

confidence: 90%

Section: Modification Of Conductive Polymers With Bioactive Moleculesmentioning

confidence: 99%

Section: Modification Of Conductive Polymers With Bioactive Moleculesmentioning

confidence: 99%

See 1 more Smart Citation

Application of conductive polymers, scaffolds and electrical stimulation for nerve tissue engineering

Ghasemi‐Mobarakeh¹,

Prabhakaran²,

Morshed³

et al. 2011

J Tissue Eng Regen Med

613

389

View full text Add to dashboard Cite

show abstract

“…1 2 neurite extension from spiral ganglion neuron explants in vitro [41], and some level of preservation of cochlea nerves in vivo [43]. Recently we reported on co-delivery of NT3 and BDNF to synergistically encourage neurite outgrowth from cochlea explants [77]. Last but not the least, concurrent electrical stimulation may work in concert with the released neurotrophins to promote neuron rescue [78,79].…”

Section: Ocp Coatings For Delivery Of Neuroactive Moleculesmentioning

confidence: 99%

Controlled delivery for neuro-bionic devices

Yue

Moulton

Cook

et al. 2013

Advanced Drug Delivery Reviews

Self Cite

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Implantable electrodes interface with the human body for a range of therapeutic as well as diagnostic applications. Here we provide an overview of controlled delivery strategies used in neuro-bionics. Controlled delivery of bioactive molecules has been used to minimise reactive cellular and tissue responses and/or promote nerve preservation and neurite outgrowth toward the implanted electrode. These effects are integral to establishing a chronically stable and effective electrode-neural communication. Drug-eluting bioactive coatings, organic conductive polymers, or integrated microfabricated drug delivery channels are strategies commonly used.

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“…Os PCs têm sido estudados em diversas aplicações tecnológicas: músculos artificiais [51][52][53][54], sistemas inteligentes de liberação controlada [7,[55][56][57][58][59], engenharia de tecido [60][61][62][63][64], biosensores [65][66][67], neurônios artificiais [68][69][70][71][72], supercapacitores [73][74][75][76][77][78] …”

Section: Aplicações Dos Pcsunclassified

Síntese e caracterização de hidro-esponjas de polímeros condutores

Antonio¹

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Síntese e caracterização de hidro-esponjas de polímeros condutores Orientador (a): Prof (a). Dr (a). Susana Ines Cordoba de TorresiSão Paulo 2016Dedicatória À Kellyda Cinnara por toda paciência, dedicação, amor e apoio incondicional à minha luta.À minha família, Maria Dalva, Maria de Lourdes, Joaquim, Quinca e Alexandra, por terem me ensinado a lutar, ser honesto e ajudado a fazer deste sonho, realidade. AGRADECIMENTOA Deus, pela vida e pela força que nunca me fez desistir.À Professora Susana, por ter me recebido como "filho científico" e ser a principal fonte de minha formação acadêmica neste trabalho.A Luiz Marcos Lira pela grande contribuição intelectual na idealização deste trabalho e grande referência, principalmente nos primeiros passos da minha formação no doutorado.Ao professor Roberto Torresi que teve grande participação na minha formação e no desenvolvimento deste trabalho.Ao Vinicius Gonçales por toda força, por todos os ensinamentos e por ter sido uma referência para todos no laboratório.Ao Professor Tom Lindfors e a todos do Laboratório de Química Analítica da Universidade Abo Akademi, Turku-Finlândia, por terem me recebido muito bem e pela grande contribuição científica a mim e a este trabalho.À Layane Souza pelo profissionalismo e grande contribuição para este trabalho.A Adriana Campos, José Ricardo, Thiago Selva, Cláudia Sá e demais amigos por todo o esforço para me ajudar a estar aqui terminando este trabalho;Ao Nedher Ramirez e a todos do Centro da Vila Mariana pelos aprendizados e pela força.A toda instituição USP, em especial ao Instituto de Química, pelo qual agradeço a todos os professores e funcionários; Ao Laboratório de Materiais Eletroativos, em especial à Aline Souza pelo profissionalismo e dedicação ao trabalho;A todos os colegas e amigos do Laboratório de Materiais Eletroativos e do IQ-USP por terem deixado minha estadia aqui bem agradável e familiar. Cito ainda, o pessoal do futebol: "Areião" e do IQ-USP.Às agências financiadoras FAPESP (nos processos 2010/17511-0 e 2013/08370-1) e Capes pelas bolsas concedidas.Aos meus pais, meus irmãos, minha avó e toda minha família.E por fim, um agradecimento especial à Kellyda Cinnara, por quem lutei todos os dias nesta caminhada, em nome de nosso amor e por tudo que ela representa para mim. Esta tese está voltada ao estudo da síntese e caracterização de hidro-esponjas de polímeros condutores estruturados sob a ação do agente molde de alaranjado de metila.A síntese destas hidro-esponjas foi realizada tanto quimicamente quanto eletroquimicamente. Na síntese química, destacam-se as hidro-esponjas de polipirrol, onde os estudos de eletrointumescimento realizados em meio aquoso, tanto a nível macroscópico (via variação de volume) quanto a nível molecular (via FTIR-ATR), mostraram que o material se comporta como um hidrogel apresentando alta capacidade de sofrer uma expansão de volume (um aumento de até 40%) e absorver grandes quantidades de água. No que se refere à síntese eletroquímica, destacam-se os filmes finos de hidro-esponja de polipirrol e ...

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Conducting polymers, dual neurotrophins and pulsed electrical stimulation — Dramatic effects on neurite outgrowth

Cited by 216 publications

References 26 publications

Application of conductive polymers, scaffolds and electrical stimulation for nerve tissue engineering

Application of conductive polymers, scaffolds and electrical stimulation for nerve tissue engineering

Controlled delivery for neuro-bionic devices

Síntese e caracterização de hidro-esponjas de polímeros condutores

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