Conducting Polymers for Tissue Regeneration <i>in Vivo</i>

Petty, Anthony J.; Keate, Rebecca; Jiang, Bin; Ameer, Guillermo A.; Rivnay, Jonathan

doi:10.1021/acs.chemmater.0c00767

Cited by 62 publications

(70 citation statements)

References 194 publications

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“…When a mechanical stress is applied, the displacement of hydrogen bonds redistributes dipole moments to the longitudinal axis of the collagen molecules, causing permanent polarization (Figure 1). [ 9c ] The piezoelectric heterogeneity within collagen fibrils correlates with the periodic variation of their overlap and gap regions. Other biomolecules and bioassemblies including proteins/peptides, [ 49 ] deoxyribonucleic acids (DNA), [ 50 ] and virus [ 51 ] have also been found to have piezoelectric effect.…”

Section: Endogenous Bioelectricity and Piezoelectricitymentioning

confidence: 99%

“…Recently, a range of electroactive biomaterials, including conductive and piezoelectric biomaterials, and their mediated electrostimulation have been developed to mimic the nature bioelectricity as a biophysical cue for modulation of stem cell fate and regenerative medicine. [ 9 ] Electroactive biomaterials are considered to be a new generation of smart biomaterials that allow directly deliver electrostimulation to target cells/tissues, or adjust their own characteristics under electrostimulation to adapt to the cell microenvironment. Electroactive biomaterials have the potentials to integrate the topological, chemical, mechanical cues, as well as electrical properties to meet the specific biological application requirements.…”

Section: Introductionmentioning

confidence: 99%

“…The reviews of electroactive biomaterials have appreciated in recent years, [ 9 ] which summarize electroactive biomaterials for tissue regeneration, and provide an overview on the current progresses of the electroactive biomaterials for drug delivery and regenerative medicine. For tissue engineering application, an in‐depth understanding of how the cell microenvironment evolves over time is critical for development of smart tissue engineering biomaterials.…”

Section: Introductionmentioning

confidence: 99%

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Electroactive Biomaterials and Systems for Cell Fate Determination and Tissue Regeneration: Design and Applications

et al. 2021

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During natural tissue regeneration, tissue microenvironment and stem cell niche including cell–cell interaction, soluble factors, and extracellular matrix (ECM) provide a train of biochemical and biophysical cues for modulation of cell behaviors and tissue functions. Design of functional biomaterials to mimic the tissue/cell microenvironment have great potentials for tissue regeneration applications. Recently, electroactive biomaterials have drawn increasing attentions not only as scaffolds for cell adhesion and structural support, but also as modulators to regulate cell/tissue behaviors and function, especially for electrically excitable cells and tissues. More importantly, electrostimulation can further modulate a myriad of biological processes, from cell cycle, migration, proliferation and differentiation to neural conduction, muscle contraction, embryogenesis, and tissue regeneration. In this review, endogenous bioelectricity and piezoelectricity are introduced. Then, design rationale of electroactive biomaterials is discussed for imitating dynamic cell microenvironment, as well as their mediated electrostimulation and the applying pathways. Recent advances in electroactive biomaterials are systematically overviewed for modulation of stem cell fate and tissue regeneration, mainly including nerve regeneration, bone tissue engineering, and cardiac tissue engineering. Finally, the significance for simulating the native tissue microenvironment is emphasized and the open challenges and future perspectives of electroactive biomaterials are concluded.

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Section: Endogenous Bioelectricity and Piezoelectricitymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Electroactive Biomaterials and Systems for Cell Fate Determination and Tissue Regeneration: Design and Applications

et al. 2021

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“…Studies of conducting polymers were performed on bones, muscles, nerves, mesenchymal cells, cardiac cells, etc., due to the sensitive nature of these cells or tissues with electrical stimulation (Alegret et al, 2018; Ferrigno et al, 2020; Petty et al, 2020; Tomczykowa & Plonska‐Brzezinska, 2019), though brittle nature, non‐biodegradability, non‐processability in common organic solvents as well as weak molecular interaction with cells, topography and mechanics limit its use in biomedical applications as biomaterials (Iqbal & Ahmad, 2018).…”

Section: Conducting Polymersmentioning

confidence: 99%

Biodegradable conducting polymeric materials for biomedical applications: a review

2020

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Biomaterials are natural or synthetic materials that are biodegradable and interact cordially with biological systems (Qu et al., 2019). These can be well-defined as a material envisioned to interface with biological systems for evaluation, treatment and replacement of organs, tissues or function of the body (Basu & Ghosh, 2017; Reis et al., 2016). They play a key role in the human health system which is attained from nature or the environment (Mir et al., 2018). Generally, biopolymers are the main class of biomaterials as biopolymers are biocompatible, biodegradable and human body-friendly (Rebelo et al., 2017). These biopolymers are further classified as biodegradable and non-biodegradable according to their nature (Andreeßen & Steinbüchel, 2019; Kabir et al., 2020). Due to their outstanding biocompatibility, biodegradable polymers are known as the best candidate for biomedical applications such as drug delivery systems, vascular grafts, surgical sutures, artificial skin, bone fixation devices, gene delivery systems, tissue engineering and diagnostic applications. Biomedical engineering is an attractive branch which deals with engineering and biology together to put on engineering materials and rudiments in the field of healthcare and medicine. Tissue engineering is also a part of it that fulfils the purposes of recovering or exchange failing or broken body tissue by merging cells, scaffolds and bioactive molecules. Scaffolds should combine various functions such as biodegradability, biocompatibility, ideal mechanical strength, adequate porosity for small molecule transportation, controllability, implantation and sterilization. Hence, natural polymers such as gelatin and chitosan are the perfect match for scaffold fabrication and synthetic aliphatic polyesters too. However, these revealed poor hydrophilicity which limits the cell attachment on surfaces and lack of sites for covalent bonding. While having their biodegradable nature, biopolymers or conventional polymers are insulators in nature so that limits the use in some biomedical applications where conducting properties of biomaterials is indispensable (George et al., 2020). In many applications of implants in the body, such as in bone fixing materials, dental materials and bone substitution materials, there is a need for such type of material showing long-term stable performance. In other applications such as controlled drug delivery, regenerative medicine, tissue engineering

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“…They affect cardiomyocyte (CM) contractility by regulating calcium propagation at the molecular level; modulating cytoskeletal and sarcomeric organization at the cellular level. [ 4 ] The nanofibrils of the native myocardium extracellular matrix (ECM) play a crucial role in cell morphology and organization, determining the localization of electrical and mechanical junctions that affect cardiac contraction. [ 5–7 ] On the other hand, substrate stiffness could be sensed by CM through the integrins connecting to the cytoskeleton, which induces cytoskeleton remodeling.…”

Section: Introductionmentioning

confidence: 99%

An In Vitro Mat‐on‐Gel Construct for Engineering Cardiac Tissue

Liang

Goh

2021

Adv Materials Inter

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Topographical and mechanical features are two key factors for cell development. Here, an easy‐to‐make Mat‐on‐Gel construct is introduced to study the co‐effects of nanogeometry and stiffness on cardiomyocyte (CM) functional development in vitro. The construct consists of electrospun fibers and polydimethylsiloxane (PDMS) gel, providing both nanofibrillar structure and adjustable stiffness. Comparison studies of three different stiffness ranging from 19 to 52 kPa are conducted using a CM cell line: HL‐1 cells. Physical characterization shows that Mat‐on‐Gel constructs possess improved hydrophilicity than PDMS gel and reduced Young's modulus than electrospun mat. It results in better cell adhesion and enhanced cell metabolic activities. CMs on the Mat‐on‐Gel constructs also present more synchronous electrophysiological activities than those cultured on electrospun fibers or PDMS gel alone. In particular, lower gel stiffness results in more rapid calcium waves. This study collectively demonstrates the feasibility of this Mat‐on‐Gel construct and its potential usage as an in vitro platform for pharmaceutical studies.

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Conducting Polymers for Tissue Regeneration in Vivo

Cited by 62 publications

References 194 publications

Electroactive Biomaterials and Systems for Cell Fate Determination and Tissue Regeneration: Design and Applications

Electroactive Biomaterials and Systems for Cell Fate Determination and Tissue Regeneration: Design and Applications

Biodegradable conducting polymeric materials for biomedical applications: a review

An In Vitro Mat‐on‐Gel Construct for Engineering Cardiac Tissue

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