Conducting Polymers to Control and Monitor Cells

Jimison, Leslie H.; Rivnay, Jonathan; Owens, Róisı́n M.

doi:10.1002/9783527650965.ch02

Cited by 6 publications

(7 citation statements)

References 156 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…CPs’ rigidity and fragility as well as poor solubility also limit their use, and therefore composites and blends are promising materials to overcome these problems . CPs possess properties that are exploitable in biomedicine such as in biosensors (i.e., chemical and physicochemical properties), biocompatible coatings, − and tissue-engineering (i.e., ionic transport, biocompatibility, and hydrophilicity), , selective membranes (i.e., ionic and electronic conductivity), neural interfaces and neural probes (i.e., ionic and electronic conductivity), − drug-delivery devices (i.e., reversible doping, see below), and bioactuators (i.e., structural changes, see below), which have been reviewed, and they highlight the potential of polythiophenes and polyanilines in this field.…”

Section: Interrelationship Between Electrochemistry and Conducting Po...mentioning

confidence: 99%

Conducting Polymers in the Fields of Energy, Environmental Remediation, and Chemical–Chiral Sensors

et al. 2018

View full text Add to dashboard Cite

Conducting polymers (CPs), thanks to their unique properties, structures made on-demand, new composite mixtures, and possibility of deposit on a surface by chemical, physical, or electrochemical methodologies, have shown in the last years a renaissance and have been widely used in important fields of chemistry and materials science. Due to the extent of the literature on CPs, this review, after a concise introduction about the interrelationship between electrochemistry and conducting polymers, is focused exclusively on the following applications: energy (energy storage devices and solar cells), use in environmental remediation (anion and cation trapping, electrocatalytic reduction/oxidation of pollutants on CP based electrodes, and adsorption of pollutants) and finally electroanalysis as chemical sensors in solution, gas phase, and chiral molecules. This review is expected to be comprehensive, authoritative, and useful to the chemical community interested in CPs and their applications.

show abstract

Section: Interrelationship Between Electrochemistry and Conducting Po...mentioning

confidence: 99%

Conducting Polymers in the Fields of Energy, Environmental Remediation, and Chemical–Chiral Sensors

et al. 2018

View full text Add to dashboard Cite

show abstract

“…1 Considering the oftentimes limited physiological relevance of 2D cell culture experiments, significant effort was subsequently devoted to the development of materials and platforms that could more accurately recreate the in vivo cellular microenvironment, and support 3D cell cultures in vitro . 2 One such class of materials is conducting polymers, which appear promising due to their compliant mechanical properties, excellent compatibility with biological systems, mixed electrical and ionic conductivity, 3 and their ability to form 3D porous structures. 4 Such 3D porous scaffolds, thus, combine large solid-state surface areas with electro-physical properties that are relevant to both organic electronics and biology.…”

Section: Introductionmentioning

confidence: 99%

3D conducting polymer platforms for electrical control of protein conformation and cellular functions

et al. 2015

View full text Add to dashboard Cite

We report the fabrication of three dimensional (3D) macroporous scaffolds made from poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) via an ice-templating method. The scaffolds offer tunable pore size and morphology, and are electrochemically active. When a potential is applied to the scaffolds, reversible changes take place in their electrical doping state, which in turn enables precise control over the conformation of adsorbed proteins (e.g., fibronectin). Additionally, the scaffolds support the growth of mouse fibroblasts (3T3-L1) for 7 days, and are able to electrically control cell adhesion and pro-angiogenic capability. These 3D matrix-mimicking platforms offer precise control of protein conformation and major cell functions, over large volumes and long cell culture times. As such, they represent a new tool for biological research with many potential applications in bioelectronics, tissue engineering, and regenerative medicine.

show abstract

“…A recent approach is to replace traditional conducting and semiconducting materials in bioelectronics applications, which have Young’s moduli in the range of MPa, with soft organic semiconductors (i.e., conjugated polymers). These materials offer biocompatibility, , attractive mechanical properties (low Young’s modulus), as well as high conductivity …”

mentioning

confidence: 99%

“…4 A recent approach is to replace traditional conducting and semiconducting materials in bioelectronics applications, which have Young's moduli in the range of MPa, with soft organic semiconductors (i.e., conjugated polymers). These materials offer biocompatibility, 5,6 attractive mechanical properties (low Young's modulus), 7 as well as high conductivity. 8 Devices based on organic semiconductor materials can be adopted for the detection or the control of various biomolecular/biological processes such as binding of specific ligands, 9 cell proliferation and migration, 6,10,11 and recording/ stimulation of action potentials in neuronal and cardiac cells.…”

mentioning

confidence: 99%

“…These materials offer biocompatibility, 5,6 attractive mechanical properties (low Young's modulus), 7 as well as high conductivity. 8 Devices based on organic semiconductor materials can be adopted for the detection or the control of various biomolecular/biological processes such as binding of specific ligands, 9 cell proliferation and migration, 6,10,11 and recording/ stimulation of action potentials in neuronal and cardiac cells. 12 Despite demonstrating a wide range of biomedical applications, current devices have been designed primarily on 2D planar interfaces while it has been recently proposed that 3D topologies are preferable for cell−chip coupling in bioelectronics.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Enhanced Cell–Chip Coupling by Rapid Femtosecond Laser Patterning of Soft PEDOT:PSS Biointerfaces

Santoro

Burgt

Keene³

et al. 2017

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

Interfacing soft materials with biological systems holds considerable promise for both biosensors and recording live cells. However, the interface between cells and organic substrates is not well studied, despite its crucial role in the effectiveness of the device. Furthermore, well-known cell adhesion enhancers, such as microgrooves, have not been implemented on these surfaces. Here, we present a nanoscale characterization of the cell-substrate interface for 3D laser-patterned organic electrodes by combining electrochemical impedance spectroscopy (EIS) and scanning electron microscopy/focused ion beam (SEM/FIB). We demonstrate that introducing 3D micropatterned grooves on organic surfaces enhances the cell adhesion of electrogenic cells.

show abstract

Conducting Polymers to Control and Monitor Cells

Cited by 6 publications

References 156 publications

Conducting Polymers in the Fields of Energy, Environmental Remediation, and Chemical–Chiral Sensors

Conducting Polymers in the Fields of Energy, Environmental Remediation, and Chemical–Chiral Sensors

3D conducting polymer platforms for electrical control of protein conformation and cellular functions

Enhanced Cell–Chip Coupling by Rapid Femtosecond Laser Patterning of Soft PEDOT:PSS Biointerfaces

Contact Info

Product

Resources

About