Conduction of excitation waves and reentry drift on cardiac tissue with simulated photocontrol-varied excitability

Nizamieva, Aygul; Kalita, I. Y.; Slotvitsky, Mihail; Berezhnoy, Andrey; Shubina, Natalia S.; Frolova, Sheida; Tsvelaya, V. A.; Agladze, Konstantin

doi:10.1063/5.0122273

Cited by 10 publications

(5 citation statements)

References 44 publications

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“…For example, such substances are azobenzene and its derivatives [31]. In our works, we tried to determine how effective the photocontrol method can be for eliminating arrhythmias [32,33]. We investigated the effect of a simulated azobenzene trimethylammonium bromide excitability gradient in cultured heart cells on the behavior and termination of reentry waves.…”

Section: Reentry Arrhythmia In Cardiac Tissue Modelsmentioning

confidence: 99%

Biomimetic Cardiac Tissue Models for In Vitro Arrhythmia Studies

Aitova,

Berezhnoy,

Tsvelaya

et al. 2023

Biomimetics

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Cardiac arrhythmias are a major cause of cardiovascular mortality worldwide. Many arrhythmias are caused by reentry, a phenomenon where excitation waves circulate in the heart. Optical mapping techniques have revealed the role of reentry in arrhythmia initiation and fibrillation transition, but the underlying biophysical mechanisms are still difficult to investigate in intact hearts. Tissue engineering models of cardiac tissue can mimic the structure and function of native cardiac tissue and enable interactive observation of reentry formation and wave propagation. This review will present various approaches to constructing cardiac tissue models for reentry studies, using the authors’ work as examples. The review will highlight the evolution of tissue engineering designs based on different substrates, cell types, and structural parameters. A new approach using polymer materials and cellular reprogramming to create biomimetic cardiac tissues will be introduced. The review will also show how computational modeling of cardiac tissue can complement experimental data and how such models can be applied in the biomimetics of cardiac tissue.

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Section: Reentry Arrhythmia In Cardiac Tissue Modelsmentioning

confidence: 99%

Biomimetic Cardiac Tissue Models for In Vitro Arrhythmia Studies

Aitova,

Berezhnoy,

Tsvelaya

et al. 2023

Biomimetics

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“…This allows for light-induced drift of spiral waves [34,35], chiral changes [36], control of turbulence [37], and other manipulations within myocardial tissue.…”

Section: Introductionmentioning

confidence: 99%

Control of spiral waves in myocardial tissue by optogenetics and temperature

Hu,

Ding,

et al. 2024

Preprint

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Optogenetics as an emerging technology can eliminate spiral waves in myocardial tissue. The heat generated during illumination of myocardial tissue is an overlooked influence. Even small fluctuations in temperature may affect the action potentials of cardiomyocyte. In this paper, a minimal ventricular model and a simplified model of optogenetics are employed to study the effects of heat generation by illumination on elimination of spiral waves. The Luo-Rudy model and Channelrhodospin-2 light-sensitive ion channel model are used to validate our conclusions. Weinduce drift of spiral waves through inhomogeneities generated by discrete gradients of illumination. The inhomogeneity of temperature caused by gradient illumination can inhibit the elimination of spiral waves. Spiral waves in the myocardial medium can be induced to drift more efficiently by controlling temperature changes in the myocardial medium during illumination. We emphasized the importance of temperature factors in optogenetic experiments, hoping that our results could provide guidance for its clinical applications.

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“…Optogenetics is a technology that enables such control at the cell, tissue, and organ level. This technique is utilized in a vast range of study purposes, from basic [28][29][30][31][32] to application studies [23,[33][34][35][36][37]. In these works, arrhythmia in genetically modified cardiac tissue is controlled by different global and structured illumination patterns.…”

Section: Introductionmentioning

confidence: 99%

Dissolution of spiral wave’s core using cardiac optogenetics

Hussaini,

Lädke,

Schröder-Schetelig

et al. 2023

PLoS Comput Biol

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Rotating spiral waves in the heart are associated with life-threatening cardiac arrhythmias such as ventricular tachycardia and fibrillation. These arrhythmias are treated by a process called defibrillation, which forces electrical resynchronization of the heart tissue by delivering a single global high-voltage shock directly to the heart. This method leads to immediate termination of spiral waves. However, this may not be the only mechanism underlying successful defibrillation, as certain scenarios have also been reported, where the arrhythmia terminated slowly, over a finite period of time. Here, we investigate the slow termination dynamics of an arrhythmia in optogenetically modified murine cardiac tissue both in silico and ex vivo during global illumination at low light intensities. Optical imaging of an intact mouse heart during a ventricular arrhythmia shows slow termination of the arrhythmia, which is due to action potential prolongation observed during the last rotation of the wave. Our numerical studies show that when the core of a spiral is illuminated, it begins to expand, pushing the spiral arm towards the inexcitable boundary of the domain, leading to termination of the spiral wave. We believe that these fundamental findings lead to a better understanding of arrhythmia dynamics during slow termination, which in turn has implications for the improvement and development of new cardiac defibrillation techniques.

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Conduction of excitation waves and reentry drift on cardiac tissue with simulated photocontrol-varied excitability

Cited by 10 publications

References 44 publications

Biomimetic Cardiac Tissue Models for In Vitro Arrhythmia Studies

Biomimetic Cardiac Tissue Models for In Vitro Arrhythmia Studies

Control of spiral waves in myocardial tissue by optogenetics and temperature

Dissolution of spiral wave’s core using cardiac optogenetics

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