Conductive biomaterials for cardiac repair: A review

Li, Yimeng; Wei, Leqian; Lan, Lizhen; Gao, Yaya; Zhang, Qian; Dawit, Hewan; Guo, Linna; Shen, Li

doi:10.1016/j.actbio.2021.04.018

Cited by 91 publications

(67 citation statements)

References 222 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Multicellular culture fails to attain adult cardiomyocytes in most cases, leading to a progressive understanding that recapitulating dynamic assembly consistent with cardiac native microenvironment may reach comparable expression and function levels in an adult phenotype (Schwach & Passier, 2019). The desired outcome requires adequate properties to allow structural, electromechanical, and biocompatible formation while avoiding adverse impacts (Li et al, 2021). Although various designed cardiac patches ultimately achieve cell maturity and tissue construct, it is imperative to incorporate electrically conductive biomaterials to facilitate more pronounced electromechanical integration of CMs.…”

Section: Biological Cues Of Cardiac Patchesmentioning

confidence: 99%

“…Three‐dimensional conductive cardiac patches play indispensable parts in yielding anisotropic laminar constructs, establishing intercellular interactions, and avoiding cellular injury, serving as biodegradable conductors applied to internal and external electrical fields (Li et al, 2021). Of note, the conductive efficacy of action potential provides intercellular communication in the profiles of gene expression and signaling pathways.…”

Section: Biological Cues Of Cardiac Patchesmentioning

confidence: 99%

“…Carbon nanotubes (CNTs) present stable distinct one‐dimensional hollow structures along with large specific surface areas, enabling increased compressive and tensile strength, reduced brittleness, high mechanical integrity, anisotropic properties, and enhanced electrical conductivity (Li et al, 2021; Roshanbinfar et al, 2019; Walker, Lara, Mogadam, et al, 2019). In the study of Van den Broeck et al, CNTs are incorporated into the compounded matrix to improve the stiffness of PEG hydrogels, implying marked cell viability and proliferation (Van den Broeck et al, 2019).…”

Section: Conductive Biomaterialsmentioning

confidence: 99%

See 2 more Smart Citations

Bioelectricity‐coupling patches for repairing impaired myocardium

Qiu

2022

WIREs Nanomed Nanobiotechnol

View full text Add to dashboard Cite

Cardiac abnormalities, which account for extensive burdens on public health and economy, drive necessary attempts to revolutionize the traditional therapeutic system. Advances in cardiac tissue engineering have expanded a highly efficacious platform to address cardiovascular events, especially cardiac infarction. Current efforts to overcome biocompatible limitations highlight the constructs of a conductive cardiac patch to accelerate the industrial and clinical landscape that is amenable for patient-accurate therapy, regenerative medicine, disease modeling, and drug delivery. With the notion that cardiac tissue synchronically contracts triggered by electrical pulses, the cardiac patches based on conductive materials are developed and treated on the dysfunctional heart. In this review, we systematically summarize distinct conductive materials serving as the most promising alternatives (conductive nanomaterials, conductive polymers, piezoelectric polymers, and ionic electrolytes) to achieve electric signal transmission and engineered cardiac tissues. Existing applications are discussed considering how these patches containing conductive candidates are fabricated into diverse forms with major strategies. Ultimately, we try to define a new concept as a bioelectricity-coupling patch that provides a favorable cardiac micro-environment for cardiac functional activities. Underlying challenges and prospects are presented regarding industrial processing and cardiovascular treatment of conductive patch progress. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Cardiovascular Diseasebioelectricity-coupling patch, conductive biomaterials, myocardial repair, tissue engineering | INTRODUCTIONCardiovascular disease (CVD) poses a widespread threat to major morbidity and mortality, resulting in immense health and financial burden. According to the updated statistics, exposure to CVD poses life-threatening impacts on living quality at the level of 17.9 million death each year (Virani et al., 2021). Ischemic heart disease (IHD), especially myocardial infarction (MI), arouses significant concerns as a commonly devastating pattern of CVD (Tang et al., 2018). The

show abstract

Section: Biological Cues Of Cardiac Patchesmentioning

confidence: 99%

Section: Biological Cues Of Cardiac Patchesmentioning

confidence: 99%

Section: Conductive Biomaterialsmentioning

confidence: 99%

See 1 more Smart Citation

Bioelectricity‐coupling patches for repairing impaired myocardium

Qiu

2022

WIREs Nanomed Nanobiotechnol

View full text Add to dashboard Cite

show abstract

“…Another example of alignment is the skeletal muscle, where cells form long polynucleated units and are all elongated along the same axis. 5 , 256 , 307 …”

Section: Tissue-electronics Bio-interfacesmentioning

confidence: 99%

Advances in Cell-Conductive Polymer Biointerfaces and Role of the Plasma Membrane

et al. 2021

View full text Add to dashboard Cite

The plasma membrane (PM) is often described as a wall, a physical barrier separating the cell cytoplasm from the extracellular matrix (ECM). Yet, this wall is a highly dynamic structure that can stretch, bend, and bud, allowing cells to respond and adapt to their surrounding environment. Inspired by shapes and geometries found in the biological world and exploiting the intrinsic properties of conductive polymers (CPs), several biomimetic strategies based on substrate dimensionality have been tailored in order to optimize the cell–chip coupling. Furthermore, device biofunctionalization through the use of ECM proteins or lipid bilayers have proven successful approaches to further maximize interfacial interactions. As the bio-electronic field aims at narrowing the gap between the electronic and the biological world, the possibility of effectively disguising conductive materials to “trick” cells to recognize artificial devices as part of their biological environment is a promising approach on the road to the seamless platform integration with cells.

show abstract

“…For this reason, it is essential for biomimetic and 471 operative cardiac recovery to restore to restore the normal electrical conduction in the infarcted heart. A conductive scaffold can connect isolated CMs to revive ventricular function and synchronise propagation and the subsequent contraction along with providing mechanical support [ 86 ].…”

Section: Non-functionalised Acellular Scaffoldsmentioning

confidence: 99%

Therapeutic Acellular Scaffolds for Limiting Left Ventricular Remodelling-Current Status and Future Directions

Perveen

Rossin

Vitale

et al. 2021

IJMS

View full text Add to dashboard Cite

Myocardial infarction (MI) is one of the leading causes of heart-related deaths worldwide. Following MI, the hypoxic microenvironment triggers apoptosis, disrupts the extracellular matrix and forms a non-functional scar that leads towards adverse left ventricular (LV) remodelling. If left untreated this eventually leads to heart failure. Besides extensive advancement in medical therapy, complete functional recovery is never accomplished, as the heart possesses limited regenerative ability. In recent decades, the focus has shifted towards tissue engineering and regenerative strategies that provide an attractive option to improve cardiac regeneration, limit adverse LV remodelling and restore function in an infarcted heart. Acellular scaffolds possess attractive features that have made them a promising therapeutic candidate. Their application in infarcted areas has been shown to improve LV remodelling and enhance functional recovery in post-MI hearts. This review will summarise the updates on acellular scaffolds developed and tested in pre-clinical and clinical scenarios in the past five years with a focus on their ability to overcome damage caused by MI. It will also describe how acellular scaffolds alone or in combination with biomolecules have been employed for MI treatment. A better understanding of acellular scaffolds potentialities may guide the development of customised and optimised therapeutic strategies for MI treatment.

show abstract

Conductive biomaterials for cardiac repair: A review

Cited by 91 publications

References 222 publications

Bioelectricity‐coupling patches for repairing impaired myocardium

Bioelectricity‐coupling patches for repairing impaired myocardium

Advances in Cell-Conductive Polymer Biointerfaces and Role of the Plasma Membrane

Therapeutic Acellular Scaffolds for Limiting Left Ventricular Remodelling-Current Status and Future Directions

Contact Info

Product

Resources

About