Conductive Hydrogel for a Photothermal-Responsive Stretchable Artificial Nerve and Coalescing with a Damaged Peripheral Nerve

Dong, Mei; Shi, Bo; Liu, Dun; Liu, Jiahao; Zhao, Di; Yu, Zheng-Hang; Shen, Xiao-Quan; Gan, Jia-Min; Shi, Benlong; Qiu, Yong; Wang, Changchun; Zhu, Zezhang; Shen, Qun‐Dong

doi:10.1021/acsnano.0c05197

Cited by 102 publications

(76 citation statements)

References 52 publications

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“…Materials with photothermal effects have been applied widely in antitumor treatment, and increasing applications in antibacterial effect, wound healing, and tissue regeneration have been reported in the past 2–3 years [ 48 ]. According to the different sources of photothermal initiators, materials with photothermal effects can be divided into two types: inorganic materials and organic materials.…”

Section: Composition Of Hydrogels With Photothermal Effectsmentioning

confidence: 99%

A Review on Hydrogels with Photothermal Effect in Wound Healing and Bone Tissue Engineering

Zhang

Tan

et al. 2021

Polymers

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Photothermal treatment (PTT) is a promising strategy to deal with multidrug-resistant bacteria infection and promote tissue regeneration. Previous studies demonstrated that hyperthermia can effectively inhibit the growth of bacteria, whereas mild heat can promote cell proliferation, further accelerating wound healing and bone regeneration. Especially, hydrogels with photothermal properties could achieve remotely controlled drug release. In this review, we introduce a photothermal agent hybrid in hydrogels for a photothermal effect. We also summarize the potential mechanisms of photothermal hydrogels regarding antibacterial action, angiogenesis, and osteogenesis. Furthermore, recent developments in photothermal hydrogels in wound healing and bone regeneration applications are introduced. Finally, future application of photothermal hydrogels is discussed. Hydrogels with photothermal effects provide a new direction for wound healing and bone regeneration, and this review will give a reference for the tissue engineering.

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Section: Composition Of Hydrogels With Photothermal Effectsmentioning

confidence: 99%

A Review on Hydrogels with Photothermal Effect in Wound Healing and Bone Tissue Engineering

Zhang

Tan

et al. 2021

Polymers

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“…[ 1 ] For instance, skins and nerve fibers steadily transmit ion‐based electrical signals even as largely deformed to retain the functions of precise self‐perception and innervated feedback. [ 2 ] Inspired by the ion‐conducting nature of human tissues, ionic conductor‐based stretchable ionotronics has gained tremendous interest as artificial skins, muscles, axons, as well as in stretchable energy storage devices and soft robotics. [ 3–6 ] Nevertheless, unlike human tissues with rather complex and hierarchical structures, most of currently reported artificial ionic conductors, involving hydrogels, organohydrogels, ionogels, and ionic elastomers, were synthesized on the basis of a homogeneous solvent‐swollen or salt‐plasticized soft chain network.…”

Section: Introductionmentioning

confidence: 99%

A Highly Robust Ionotronic Fiber with Unprecedented Mechanomodulation of Ionic Conduction

Yao

Feng

et al. 2021

Advanced Materials

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unlike human tissues with rather complex and hierarchical structures, most of currently reported artificial ionic conductors, involving hydrogels, organohydrogels, ionogels, and ionic elastomers, were synthesized on the basis of a homogeneous solvent-swollen or salt-plasticized soft chain network. [4,[7][8][9][10][11] Despite high stretchability and optical transparency, such a soft network shows negligible or very small modulating effect on ion transportation; as a result, the ionic conductivity does not change or only slightly increases as stretched due to the preferential orientation of elastic chains. Generally, the mechanoelectric response of the current ionic conductors is just between conductivityconstant conductors (e.g., ionic liquids, [12] liquid metals, [13] viscoelastic gels, [11] etc.; conductivity change, σ/σ 0 = 1) and resistance-constant conductors (e.g., buckling sheath-core fibers, [14] liquid metal-elastomer composites, [15] etc.; σ/σ 0 = λ 2 , λ is the deformation ratio) (Figure 1a). It is well-known that the output resistance (R) is governed by Pouillet's Law (R = L/(σ•A)), with A designating the cross-sectional area and L the length (during stretch, L increases while A is reduced). Understandably, the moderate electrical response of ionic conductors not only limits their strain sensing applications toward high gauge factors as do percolating electronic conductors with strain-induced deteriorated conductivity, [16] but also goes against interconnect applications that require straininsensitive resistance to maintain stable electrical transmission. So far, it remains a formidable challenge for stretchable ionic conductors to overcome the seemingly inherent yet tardy mechanoelectric response arising from the poor modulating ability of soft chain network for ionic conduction.It is reported that the network topology of ionic conductors at nanometer scales is of paramount importance in altering the mobility of ionic species. [17,18] In nanofluidics, tortuosity is defined as the ratio of actual ion pathway length to the straight end-to-end distance. Highly ordered or longitudinally aligned ion-insulating nanostructures can afford low-tortuosity pathways to promote ion transport and thus significantly reduce apparent resistance. [19] Therefore, it could be feasible to introduce large amounts of ion-insulating rigid molecular units into the elastic network of ionic conductors to modulate ion transport via tortuosity changes. We consider that, liquid crystal elastomers (LCEs) might be one of the best candidate materials for this purpose, as they encompass the properties of polymeric Stretchable ionic conductors are appealing for tissue-like soft electronics, yet suffer from a tardy mechanoelectric response due to their poor modulation of ionic conduction arising from intrinsic homogeneous soft chain network. Here, a highly robust ionotronic fiber is designed by synergizing ionic liquid and liquid crystal elastomer with alternate rigid mesogen units and soft chain spacers, which shows an unprecedented s...

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“… Type of smart/stimuli-responsive hydrogel Smart/stimuli-responsive hydrogel polymer Smart/stimuli-responsive hydrogel system Stimuli Biomedical applications Year Refs. Physical-responsive hydrogels Temperature-responsive hydrogels -Poly(N-isopropylacrylamide) (PNIPAAm) -PNIPAAM covalently grafted onto a flat substrate that forms the bottom of the microfluidic device -Temperature -Microfluidic actuators 2018 [ 332 ] -Methylacrylate gelatin (GelMA) -GelMA-PDA-ASP nanocomposite hydrogels -Temperature -Dressing to enhance skin wound healing -Targeted delivery of ASP 2021 [ 333 ] -Polyacrylamide (PAAM) -Poly(N-isopropylacrylamide) (PNIPAAm) -CNW–PAAm–PNIPAm nanocomposites -Temperature -PH -Promising for different biomedical applications 2015 [ 222 ] -Poly(N-isopropylacrylamide) (PNIPAAm)-Hydrophobically associated polyacrylamide (HAPAM) hydrogel (HAPAM-PNIPAAM) -Mxene-HAPAM-PNIPAAM nanocomposite double-network hydrogel -Temperature -Compression/stress -Smart compression biosensors 2019 [ 192 ] Light/photo-responsive hydrogels -Polyacrylamide (PAAM) -Conducting polymer hydrogel (CPH) based on copolymerized PANI and PAM (PAM/PANI CPH) -NIR light -Neural tissue engineering 2020 [ 334 ] -Poly(N-isopropylacrylamide) (PNIPAAM) -Poly(diketopyrrolopyrrole-alt-3,4 ethylenedioxythiophene)-PNIPAAm -NIR light -Targeted and controlled drug delivery for cancer treatment 2017 [ 136 ] -Poly(N,N-dimethylacrylamide (PDMA) -PDMA/Coumarin copolymers -Photo/light -Promising for different biomedical applications 2018 [ 125 ] Electric-responsive hydrogels -Carboxymethyl chitosan (CMCH) …”

Section: Smart/stimuli-responsive Hydrogels Employed For Different Biomedical Applicationsmentioning

confidence: 99%

Smart/stimuli-responsive hydrogels: Cutting-edge platforms for tissue engineering and other biomedical applications

El-Husseiny

Mady

Hamabe

et al. 2022

Materials Today Bio

223

139

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Recently, biomedicine and tissue regeneration have emerged as great advances that impacted the spectrum of healthcare. This left the door open for further improvement of their applications to revitalize the impaired tissues. Hence, restoring their functions. The implementation of therapeutic protocols that merge biomimetic scaffolds, bioactive molecules, and cells plays a pivotal role in this track. Smart/stimuli-responsive hydrogels are remarkable three-dimensional (3D) bioscaffolds intended for tissue engineering and other biomedical purposes. They can simulate the physicochemical, mechanical, and biological characters of the innate tissues. Also, they provide the aqueous conditions for cell growth, support 3D conformation, provide mechanical stability for the cells, and serve as potent delivery matrices for bioactive molecules. Many natural and artificial polymers were broadly utilized to design these intelligent platforms with novel advanced characteristics and tailored functionalities that fit such applications. In the present review, we highlighted the different types of smart/stimuli-responsive hydrogels with emphasis on their synthesis scheme. Besides, the mechanisms of their responsiveness to different stimuli were elaborated. Their potential for tissue engineering applications was discussed. Furthermore, their exploitation in other biomedical applications as targeted drug delivery, smart biosensors, actuators, 3D and 4D printing, and 3D cell culture were outlined. In addition, we threw light on smart self-healing hydrogels and their applications in biomedicine. Eventually, we presented their future perceptions in biomedical and tissue regeneration applications. Conclusively, current progress in the design of smart/stimuli-responsive hydrogels enhances their prospective to function as intelligent, and sophisticated systems in different biomedical applications.

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Conductive Hydrogel for a Photothermal-Responsive Stretchable Artificial Nerve and Coalescing with a Damaged Peripheral Nerve

Cited by 102 publications

References 52 publications

A Review on Hydrogels with Photothermal Effect in Wound Healing and Bone Tissue Engineering

A Review on Hydrogels with Photothermal Effect in Wound Healing and Bone Tissue Engineering

A Highly Robust Ionotronic Fiber with Unprecedented Mechanomodulation of Ionic Conduction

Smart/stimuli-responsive hydrogels: Cutting-edge platforms for tissue engineering and other biomedical applications

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