Conductive hydrogels for tissue repair

Liang, Yongping; Qiao, Lipeng; Qiao, Bowen; Guo, Baolin

doi:10.1039/d3sc00145h

Cited by 61 publications

(36 citation statements)

References 176 publications

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“…Several studies have reported that conductive substrates can promote the intercellular connection of CMs with an upregulation of Cx43 expression and synchronous CM contraction. 13,16,21,45,62 The upregulation of Cx43 in the CAH patch group implies promoted electric coupling and contraction, which can be correlated with the elevated LV functions in ECG analysis (Figure 7B and 7C). Our findings suggested that the CAH cardiac patch had substantial therapeutic effects on the repair of infarcted heart tissues by promoting angiogenesis, inflammation resolution by macrophages, and restoration of Cx43 expression.…”

Section: Resultsmentioning

confidence: 86%

A Conductive and Adhesive Hydrogel Composed of MXene Nanoflakes as a Paintable Cardiac Patch for Infarcted Heart Repair

et al. 2023

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Myocardial infarction (MI) is a major cause of death worldwide. After the occurrence of MI, the heart frequently undergoes serious pathological remodeling, leading to excessive dilation, electrical disconnection between cardiac cells, and fatal functional damage. Hence, extensive efforts have been made to suppress pathological remodeling and promote the repair of the infarcted heart. In this study, we developed a hydrogel cardiac patch that can provide mechanical support, electrical conduction, and tissue adhesiveness to aid in the recovery of an infarcted heart function. Specifically, we developed a conductive and adhesive hydrogel (CAH) by combining the two-dimensional titanium carbide (Ti3C2Tx) MXene with natural biocompatible polymers [i.e., gelatin and dextran aldehyde (dex-ald)]. The CAH was formed within 250 s of mixing the precursor solution and could be painted. The hydrogel containing 3.0 mg/mL MXene, 10% gelatin, and 5% dex-ald exhibited appropriate material characteristics for cardiac patch applications, including a uniform distribution of MXene, a high electrical conductivity (18.3 mS/cm), cardiac tissue-like elasticity (30.4 kPa), strong tissue adhesion (6.8 kPa), and resistance to various mechanical deformations. The CAH was cytocompatible and induced cardiomyocyte (CM) maturation in vitro, as indicated by the upregulation of connexin 43 expression and a faster beating rate. Furthermore, CAH could be painted onto the heart tissue and remained stably adhered to the beating epicardium. In vivo animal studies revealed that CAH cardiac patch treatment significantly improved cardiac function and alleviated the pathological remodeling of an infarcted heart. Thus, we believe that our MXene-based CAH can potentially serve as a promising platform for the effective repair of various electroactive tissues including the heart, muscle, and nerve tissues.

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Section: Resultsmentioning

confidence: 86%

A Conductive and Adhesive Hydrogel Composed of MXene Nanoflakes as a Paintable Cardiac Patch for Infarcted Heart Repair

et al. 2023

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“…Although natural ROS scavenging enzymes, such as superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GP x ), feature excellent ROS-clearing capabilities, they suffer from low stability, high cost and limited capacity for large-scale production. 9 To address these issues, researchers have developed a series of artificial enzymes, nanomaterials, and responsive polymers with the capability to eliminate excess ROS and reduce oxidative stress, 10–14 which have been verified to have vast potential in the treatment of cardiac disorders, 15 Alzheimer's disease (AD), 16 spinal cord injury, 17–19 cancer, 20 osteoarthritis, 21 skin wounds, 22 inflammatory bowel disease, 23 and so on. For example, Wei et al reported an integrated cascade nanozyme with the formulation Pt@PCN222-Mn, which could simultaneously mimic superoxide dismutase and catalase to consume over-produced ROS for the efficient treatment of inflammatory bowel diseases.…”

Section: Introductionmentioning

confidence: 99%

Green polymer hydrogels from a natural monomer with inherent antioxidative capability for efficient wound healing and spinal cord injury treatment

Wang

et al. 2023

Biomater. Sci.

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“…Recently, great efforts have been made in the design and construction of electro-stimulated drug delivery systems due to their unrivaled rapidity, reversibility, and localization. , Therefore, multifarious conductive hydrogels have been prepared with diverse conducting materials through various synthetic tactics. Chung et al reported a conductive blended hydrogel by mixing alginate with gelatin methacrylate and silver nanowires .…”

Section: Introductionmentioning

confidence: 99%

Conductive Viologen Hydrogel Based on Hyperbranched Polyamidoamine for Multiple Stimulus-Responsive Drug Delivery

Zhao

Zhou

Wang³

et al. 2023

ACS Appl. Mater. Interfaces

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The emergence of precision medicine and personalized pharmacotherapy has led to the development of advanced drug delivery systems that can respond to multiple stimuli. Conductive hydrogels have excellent electrical signal responsiveness and drug storage capabilities; however, current conductive hydrogels suffer from poor mechanical properties, low ionic conductivity, and high voltage. Herein, a covalently crosslinked viologen hydrogel was prepared using electroactive hyperbranched polyamidoamine (EHP) as the crosslinking center in a polymeric network. Attributed to its unique molecular architecture, this hydrogel exhibits improved mechanical properties (high tensile strength and desirable stretchability up to 1280%). Approvable ionic conductivity, biocompatibility, antibacterial properties, and wearable strain-sensing performance were also disclosed, ascribed to the participation of versatile viologen groups in the hydrogel structure. This hydrogel exhibited high efficiency in drug release (81.6%) at a lower voltage of −1.2 V. Moreover, fascinating pH-stimulus drug release behavior was also demonstrated in both acidic and alkalescent environments owing to the dramatic conformational transition of EHP. This work provides a new design strategy for conductive hydrogels for multiple stimulusresponsive drug delivery systems.

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Conductive hydrogels for tissue repair

Abstract: Conductive hydrogels (CHs) combine the biomimetic properties of hydrogels with the physiological and electrochemical properties of conductive materials, which have attracted extensive attention in the past few years. In addition,...

Cited by 61 publications

References 176 publications

A Conductive and Adhesive Hydrogel Composed of MXene Nanoflakes as a Paintable Cardiac Patch for Infarcted Heart Repair

A Conductive and Adhesive Hydrogel Composed of MXene Nanoflakes as a Paintable Cardiac Patch for Infarcted Heart Repair

Green polymer hydrogels from a natural monomer with inherent antioxidative capability for efficient wound healing and spinal cord injury treatment

Conductive Viologen Hydrogel Based on Hyperbranched Polyamidoamine for Multiple Stimulus-Responsive Drug Delivery

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