Conductive, self-healing, and antibacterial Ag/MXene-PVA hydrogel as wearable skin-like sensors

Li, Lumin; Ji, Xiaofeng; Chen, Kai

doi:10.1177/08853282221131137

Cited by 16 publications

(16 citation statements)

References 58 publications

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“…In addition, Ag/MXene conferred antibacterial activity to the hydrogels. 60 In a similar approach, silver nanowires (Ag NWs) were embedded into a self-healable hydrogel made of Alg modified with 3-aminophenylboronic acid (Alg-PBA) and Alg modified with dopamine (Alg-DA) (Figure 3B). The hydrogels were successfully extruded through syringes of different sizes, featuring tip diameters spanning from 0.86 mm to 0.27 mm.…”

Section: Synthesis and Characterization Of Injectable Conductive Gelsmentioning

confidence: 99%

Recent Advances and Developments in Injectable Conductive Polymer Gels for Bioelectronics

Peñas-Núñez,

Mecerreyes,

Criado-Gonzalez

2024

ACS Appl. Bio Mater.

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Soft matter bioelectronics represents an emerging and interdisciplinary research frontier aiming to harness the synergy between biology and electronics for advanced diagnostic and healthcare applications. In this context, a whole family of soft gels have been recently developed with self-healing ability and tunable biological mimetic features to act as a tissuelike space bridging the interface between the electronic device and dynamic biological fluids and body tissues. This review article provides a comprehensive overview of electroactive polymer gels, formed by noncovalent intermolecular interactions and dynamic covalent bonds, as injectable electroactive gels, covering their synthesis, characterization, and applications. First, hydrogels crafted from conducting polymers (poly(3,4-ethylene-dioxythiophene) (PEDOT), polyaniline (PANi), and polypyrrole (PPy))-based networks which are connected through physical interactions (e.g., hydrogen bonding, π−π stacking, hydrophobic interactions) or dynamic covalent bonds (e.g., imine bonds, Schiff-base, borate ester bonds) are addressed. Injectable hydrogels involving hybrid networks of polymers with conductive nanomaterials (i.e., graphene oxide, carbon nanotubes, metallic nanoparticles, etc.) are also discussed. Besides, it also delves into recent advancements in injectable ionic liquid-integrated gels (iongels) and deep eutectic solvent-integrated gels (eutectogels), which present promising avenues for future research. Finally, the current applications and future prospects of injectable electroactive polymer gels in cutting-edge bioelectronic applications ranging from tissue engineering to biosensing are outlined.

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Section: Synthesis and Characterization Of Injectable Conductive Gelsmentioning

confidence: 99%

Recent Advances and Developments in Injectable Conductive Polymer Gels for Bioelectronics

Peñas-Núñez,

Mecerreyes,

Criado-Gonzalez

2024

ACS Appl. Bio Mater.

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“…As shown in Scheme 1(c), the middle drug-loading dressing consists of three preparation steps, the first steps is the synthesis of Ag nanoparticle (Ag NP), the second one is the determination of the optimal mixing concentration of Ag NP and BBR, and the last one is the assembly process of the intermediate dressing. Ag NP was prepared by sodium citrate reduction method 12 : Silver nitrate solution (1 mmol/ L, 200 mL) was heated and refluxed to boiling at 150°C, 18 mL of sodium citrate solution (1 wt%) was then slowly added into the solution until it turned yellow green. After the solution was cooled to room temperature, the supernatant was removed through multiple centrifugations to obtain Ag NP sol, which was sealed and stored in a refrigerator at 4°C.…”

Section: Preparation Of the Intermediate Dressing And Self-assembling...mentioning

confidence: 99%

Preparation of berberine hydrochloride-Ag nanoparticle composite antibacterial dressing based on 3D printing technology

Chen,

Xie,

Yan

et al. 2023

J Biomater Appl

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In recent years, Ag nanoparticle (Ag NP)-loaded antibacterial dressings have attracted much attention in high-level medical dressings. However, the high cytotoxicity of Ag NP has always been a problem. In this paper, we examined the improvement of antibacterial activity of berberine hydrochloride (BBR) with Ag NP, the results showed that the combined use of BBR and Ag NP can effectively reduce the dosage of Ag NP while ensuring the inhibition of bacterial growth, thus an intermediate layer dressing containing combined drugs were prepared. At the same time, the top dressing of polyvinyl alcohol (PVA) solid film and the PVA bottom dressings with three kinds of leakage structures were prepared by 3D printing technology. Three kinds of PVA bottom dressings showed high quality consistency, and the greater the number of leak holes, the higher the porosity value of the dressing, while the swelling ratio value of the bottom layer dressing with three holes was the lowest. Finally, three types of BBR-Ag NP composite antibacterial dressings (3D-BBR-Ag NP) can be obtained by self-assembling of the top dressing, the intermediate layer dressing, and the bottom dressings with three kinds of leakage structures. The cumulative drug release results showed that dressing with more holes had a faster drug release rate compared to the other two ones with fewer leakage holes. Besides, five drug release kinetic models were used to investigate the cumulative BBR release profiles for three types of 3D-BBR-Ag NP. And the three types of composite dressings showed strong antibacterial activity after 6 h of cultivation with staphylococcus aureus. The study showed that the antibacterial activity of the self-assembled dressing prepared by combination of BBR with Ag NP can be improved, and the drug release rate of the hydrogel dressing can be flexibly controlled through 3D printing technology.

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“…[48][49][50] Li et al incorporated Ag/MXene nanocomposites into a borax (PB) cross-linked polyvinyl alcohol (PVA) matrix, creating a composite conductive hydrogel with self-healing, excellent antibacterial properties, and strain sensitivity. 51 Wang et al prepared a conductive double network PVA/SA/MXene hydrogel based on MXene, which exhibited excellent cell compatibility, high stretchability (up to 263%), outstanding fatigue resistance (up to 1000 cycles of stretching), and good sensing sensitivity (response time of 62.5 ms). 52 Chen et al prepared the double network MXene-PAM/ Agar organic hydrogel, which exhibited good electrical conductivity (1.02 S m À1 ), mechanical properties and good strain sensitivity in cold environments.…”

Section: Introductionmentioning

confidence: 99%

“…Using MXene as a filler to construct multifunctional conductive composite hydrogels is a viable strategy 48–50 . Li et al incorporated Ag/MXene nanocomposites into a borax (PB) cross‐linked polyvinyl alcohol (PVA) matrix, creating a composite conductive hydrogel with self‐healing, excellent antibacterial properties, and strain sensitivity 51 . Wang et al prepared a conductive double network PVA/SA/MXene hydrogel based on MXene, which exhibited excellent cell compatibility, high stretchability (up to 263%), outstanding fatigue resistance (up to 1000 cycles of stretching), and good sensing sensitivity (response time of 62.5 ms) 52 .…”

Section: Introductionmentioning

confidence: 99%

A double‐dynamic‐bond crosslinked multifunctional conductive hydrogel with self‐adhesive, remoldability, and rapid self‐healing properties for wearable sensing

Li,

Zhang,

Song

et al. 2023

Polymers for Advanced Techs

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In recent years, conductive hydrogels have been designed as flexible sensors with broad application prospects in the field of smart wearable devices. However, the coordination of the mechanical properties, self‐healing capability, and conductivity of hydrogels has always been a challenge. In this work, a multifunctional conductive hydrogel with self‐adhesive, re‐shapeable, and rapid self‐healing abilities (PB‐PACS‐PM3 (self‐healing efficiency) = 98.8% in 15 s) was prepared by incorporating protocatechualdehyde modified carboxymethyl chitosan (PA@o‐CMCS) and PDA‐modified MXene (PDA@MXene) into the interchain of polyvinyl alcohol through dynamic borate ester crosslinking. The dynamic Schiff base reaction not only effectively introduced o‐CMCS as a mechanical enhancer but also improved the viscoelasticity and self‐healing capability of the hydrogel through the dual dynamic bond crosslinking structure. The PDA@MXene nanosheets are uniformly distributed in the hydrogel, providing the composite system with excellent conductivity (the conductivity of PB‐PACS‐PM3 hydrogel is 1.5 S/m) and strain sensitivity (the response time and recovery time of the hydrogel sensor are 230 and 260 ms, respectively), while the tensile strength of the hydrogel is improved to 0.035 MPa. Due to all these advantages, this conductive hydrogel can be assembled into flexible wearable sensors for rapid and accurate monitoring of various physiological activities of the human body, such as finger, wrist, elbow, and knee bending vibrations, among others.

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Conductive, self-healing, and antibacterial Ag/MXene-PVA hydrogel as wearable skin-like sensors

Cited by 16 publications

References 58 publications

Recent Advances and Developments in Injectable Conductive Polymer Gels for Bioelectronics

Recent Advances and Developments in Injectable Conductive Polymer Gels for Bioelectronics

Preparation of berberine hydrochloride-Ag nanoparticle composite antibacterial dressing based on 3D printing technology

A double‐dynamic‐bond crosslinked multifunctional conductive hydrogel with self‐adhesive, remoldability, and rapid self‐healing properties for wearable sensing

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