Isolated condyloma acuminatum of the oral cavity: a short case report. Introduction: A condyloma acuminatum is a benign tumor considered to be a sexuallytransmitted infection. The viruses responsible are 90 % the human papilloma viruses types 6 and 11. They present low risk of cancer. The aim of this short case report is to state the clinical, histological and therapeutic aspects of condyloma acuminata of oral localization, and also to examine the pathways of non-sexual transmission. Observation: A thirty-yearold patient without sexual oro-genital activities consulted for whitish millimeter-length lesions localized in the hard palate and the left labial corners which had appeared a year ago. The surgical excision of both lesions of the hard palate were performed, as well as a biopsy of the left labial commissure, completed by electrocoagulation. The histological exam concluded the diagnosis of condyloma acuminata. No recurrence was recorded during the ten months of post-operative follow-up. Discussion: Oral lesions of condyloma acuminatum are very seldom and often secondary to contamination through direct sexual contact. Meanwhile, other transmission pathways not related to direct sexual contact are described. The diagnosis of condyloma acuminatum is clinical and confirmed by a histological exam. Radical treatment based mainly on surgical excision or electrocoagulation is imperative because of the highly contagious character of this lesion. Conclusion: Condyloma acuminatum is very seldom localized in the oral cavity. Diagnosis is mainly based on medical history and a histological exam.