2019
DOI: 10.1246/bcsj.20180311
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Conferment of CO-Controlled Dimer–Monomer Transition Property to Thermostable Cytochrome c′ by Mutation in the Subunit–Subunit Interface

Abstract: Cytochrome c' (CP) is a gas-binding homo-dimeric heme protein. Mesophilic Allochromatium vinosum CP (AVCP) and thermophilic Hydrogenophilus thermoluteolus CP (PHCP) have high sequence and structure similarities. AVCP is known to exhibit a dimer-monomer transition upon CO binding/dissociation, whereas detailed CO-binding properties of PHCP remain unrevealed. Here, we found that the CO-binding affinity of wild-type PHCP is lower than that of AVCP, and the PHCP dimer does not dissociate to monomers under CO-satur… Show more

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“…Observation and understanding of nanosized objects and nanolevel phenomena are rapidly developed. , On the other hand, recent material innovations strongly focus on low-dimensional materials, especially 2D materials. This progress actively contributes to various social demands including energy, , the environment, , and biomedical issues. , These emerging trends, nanolevel properties, and 2D material systems fit well with the research focus on thin film technologies, SAMs, LbLs, and LB. In fact, the importance of surfaces and interfaces is well recognized in various research systems including (i) basic science based on molecular assembly, film formation, nanomaterial assembly, surface modification, surface wettability, , interfacial reactions, , catalysis, electrochemistry, surface-specific properties, , and properties of 2D materials, (ii) interfacial designs and understanding for devices such as solar cells, , sensors, , organic field-effect transistors, batteries, , light-emitting diodes, and device fabrication, , and (iii) interfacial biorelated phenomena such as interfacial water structures, microscopic biomaterial interfaces, drug permeation through membranes, enzyme regulation, , and tissue engineering , (Figure ).…”
Section: Introductionmentioning
confidence: 99%
“…Observation and understanding of nanosized objects and nanolevel phenomena are rapidly developed. , On the other hand, recent material innovations strongly focus on low-dimensional materials, especially 2D materials. This progress actively contributes to various social demands including energy, , the environment, , and biomedical issues. , These emerging trends, nanolevel properties, and 2D material systems fit well with the research focus on thin film technologies, SAMs, LbLs, and LB. In fact, the importance of surfaces and interfaces is well recognized in various research systems including (i) basic science based on molecular assembly, film formation, nanomaterial assembly, surface modification, surface wettability, , interfacial reactions, , catalysis, electrochemistry, surface-specific properties, , and properties of 2D materials, (ii) interfacial designs and understanding for devices such as solar cells, , sensors, , organic field-effect transistors, batteries, , light-emitting diodes, and device fabrication, , and (iii) interfacial biorelated phenomena such as interfacial water structures, microscopic biomaterial interfaces, drug permeation through membranes, enzyme regulation, , and tissue engineering , (Figure ).…”
Section: Introductionmentioning
confidence: 99%