Confidence intervals for odds ratio in matching pairs under inverse sampling

Abstract

Odds ratio is often used in matched pair design to assess the equivalence of two treatments for both prospective and retrospective clinical trials. In this context, we propose five confidence intervals estimator for the odds ratio in matching pairs under inverse sample. The performance of the proposed methods are evaluated with respect to their coverage probability and expected widths. Our empirical results show that the confidence interval based on the score statistic produce similar coverage probabilities and smaller confidence interval widths.

Confidence intervals for relative difference in matching pairs under inverse sampling

“…Such design increases the efficiency of the study and eliminate the effects of some nuisance confounders [1] . McNemar [2] has done some work on matched pair binary response trial for the first time, which use 2 2 × contingency table to test the equivalence of two treatments.…”