Nowadays, there are several electric vehicles (EV) on the market, due to the innovation of technology that promotes new components such as batteries, transmissions, and electric motors. This study proposes the design procedure for the configuration synthesis and simulation of in-wheel-hub motor transmissions with six-link mechanisms. The synthesis process shows six mechanisms with six members and eight joints, 15 new clutchless motor transmissions, and 16 new clutched motor transmissions. A novel motor transmission with the possibility of synthesized configurations is chosen as a case to analyze the working rules connected with the power flow modes and operation modes. Moreover, this design is modeled for the simulation process that generates the results of the operation mode transition and energy regulation.