Replacing natural aggregates in infrastructure with recycled construction and demolition waste (RCDW) works helps to meet the requirements established by sustainable development. This environmentally friendly proposal undoubtedly becomes better when it is carried out with geosynthetics, providing better technical performance and positive economic impacts. However, the chemical characteristics of RCDW may result in the degradation of the geosynthetics and, therefore, must be assessed and quantified. This study aims to assess the chemical degradation caused by RCDW for the mechanical properties of two types of polymeric geogrids (polyester and polyvinyl alcohol). The study evaluates the influence of the RCDW saturation condition in the chemical degradation and the possible synergism between the launching damage (drop height) and chemical degradation. Watertight tanks were constructed to maintain the geosynthetic reinforced layers in flooded, dry and open-to-environment conditions, simulating paved and unpaved roads. The occurrence of degradation was evaluated and quantified by reduction factors related to the properties of interest using statistical analysis. The results have shown a significant influence of chemical degradation on the geogrid characteristics (especially tensile strength and secant tensile stiffness), which increased when the specimens were subjected to prior launching process simulation. The reduction factor values reported herein encourage the combined use of these materials (geogrid and RCDW) and highlight the importance of assessing the chemical degradation for the design purposes of geosynthetic-reinforced roadways with alternative materials.